Compounds > jcc 76

Page last updated: 2024-11-13

jcc 76

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	24873741
CHEMBL ID	574422
MeSH ID	M0560077

Synonyms (4)

Synonym
CHEMBL574422
jcc76
n-[3-[(2,5-dimethylphenyl)methoxy]-4-[methyl(methylsulfonyl)amino]phenyl]cyclohexanecarboxamide
1021926-22-6

Research Excerpts

Pharmacokinetics

Excerpt	Reference	Relevance
" Pharmacokinetic studies demonstrate the good bioavailability of the compound."	( From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation. Cai, X; Chennamaneni, S; Dowlati, A; Liu, L; Pink, JJ; Su, B; Xu, Y; Yi, X; Zhong, B; Zhou, A, 2012)	0.38

Bioavailability

Excerpt	Reference	Relevance
" Pharmacokinetic studies demonstrate the good bioavailability of the compound."	( From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation. Cai, X; Chennamaneni, S; Dowlati, A; Liu, L; Pink, JJ; Su, B; Xu, Y; Yi, X; Zhong, B; Zhou, A, 2012)	0.38

Dosage Studied

Excerpt	Relevance	Reference
" Intraperitoneal injection with a dosage of 5 mg/kg/d of CSUOH0901 to nude mice suppresses HT29 colorectal xenograft growth."	( From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation. Cai, X; Chennamaneni, S; Dowlati, A; Liu, L; Pink, JJ; Su, B; Xu, Y; Yi, X; Zhong, B; Zhou, A, 2012)	0.38

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay ID	Title	Year	Journal	Article
AID672082	Inhibition of bovine brain tubulin polymerization at 5 uM after 20 mins by spectrophotometric analysis	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Identification of a class of novel tubulin inhibitors.
AID616938	Antiproliferative activity against human SKBR3 cells after 48 to 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18	Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76.
AID1373410	Growth inhibition of human SKBR3 cells	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Synthesis and biological evaluation of anti-cancer agents that selectively inhibit Her2 over-expressed breast cancer cell growth via down-regulation of Her2 protein.
AID1373411	Growth inhibition of human MCF7 cells	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Synthesis and biological evaluation of anti-cancer agents that selectively inhibit Her2 over-expressed breast cancer cell growth via down-regulation of Her2 protein.
AID672087	Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Identification of a class of novel tubulin inhibitors.
AID756783	Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and anticancer mechanism investigation of dual Hsp27 and tubulin inhibitors.
AID639279	Ratio of nimesulide IC50 to compound IC50 for human SK-BR-3 cells	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID734444	Antiproliferative activity against human NCI-H292 2D monolayer cells after 3 days by MTT assay	2013	Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4	Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing.
AID734442	Ratio of IC50 for human NCI-H292 2D monolayer cells to IC50 for human NCI-H292 cells in 3D multi-cellular spheroid form	2013	Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4	Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing.
AID677620	Antitrypanosomal activity against bloodstream form of Trypanosoma brucei 427 after 48 hrs by MTS assay	2012	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17	Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.
AID734443	Antiproliferative activity against human NCI-H292 cells in 3D multi-cellular spheroid form after 7 days by inverted microscopy	2013	Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4	Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing.
AID756776	Inhibition of bovine brain tubulin polymerization at 5 uM after 20 mins by spectrophotometric analysis relative to control in presence of GTP	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and anticancer mechanism investigation of dual Hsp27 and tubulin inhibitors.
AID756773	Inhibition of HSP27 (unknown origin) assessed as increase in DTT-induced insulin B chain aggregation at 5 uM incubated for 5 mins prior to DTT-treatment measured after 30 mins by spectrophotometric analysis relative to control	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and anticancer mechanism investigation of dual Hsp27 and tubulin inhibitors.
AID1373412	Growth inhibition of human MDA-MB-231 cells	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Synthesis and biological evaluation of anti-cancer agents that selectively inhibit Her2 over-expressed breast cancer cell growth via down-regulation of Her2 protein.
AID638739	Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID438000	Cytotoxicity against human LTEDaro cells after 72 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23	Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells.
AID677622	Selectivity ratio of IC50 for human SKBR3 cells to IC50 for bloodstream form of Trypanosoma brucei 427	2012	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17	Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.
AID1373418	Inhibition of HSP27 chaperone activity in human SKBR3 cells assessed as reduction in Her2 protein level at 1 uM incubated for 48 hrs by Western blot	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Synthesis and biological evaluation of anti-cancer agents that selectively inhibit Her2 over-expressed breast cancer cell growth via down-regulation of Her2 protein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	7 (87.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	13.24 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	5.43 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (13.24)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
indibulin indibulin: Tubulin Modulator/Antineoplastic Agent; structure in first source	2.07	1	0
nocodazole [no description available]	2.48	2	0	aromatic ketone; benzimidazoles; carbamate ester; thiophenes	antimitotic; antineoplastic agent; microtubule-destabilising agent; tubulin modulator
nimesulide nimesulide: structure. nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.	2.47	2	0	aromatic ether; C-nitro compound; sulfonamide	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.07	1	0	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
vinblastine [no description available]	2.07	1	0
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.07	1	0	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
biotin vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.	2.06	1	0	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite
5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole 5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole: inhibits Hsp27 phosphorylation; structure in first source	2.07	1	0
e 7010 E 7010: inhibits tubulin polymerization; structure given in first source	2.07	1	0	sulfonamide
nsc751382 [no description available]	2.99	4	0

Condition	Indicated	Relationship Strength	Studies	Trials
Breast Cancer [description not available]	0	2.49	2	0
Breast Neoplasms Tumors or cancer of the human BREAST.	0	2.49	2	0
African Sleeping Sickness [description not available]	0	2.07	1	0
Trypanosomiasis, African A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.	0	2.07	1	0