| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|
| dequalinium chloride | [no description available] | medium | 2 | 0 | organic chloride salt | antifungal agent;
antineoplastic agent;
antiseptic drug;
mitochondrial NADH:ubiquinone reductase inhibitor |
| ucl 1684 | [no description available] | medium | 1 | 0 | | |
| n-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine | [no description available] | medium | 3 | 0 | | |
| (r)-n-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine | [no description available] | medium | 1 | 0 | | |
| quinacrine | [no description available] | medium | 1 | 0 | acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound | antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | [no description available] | medium | 1 | 0 | non-proteinogenic alpha-amino acid | |
| 1,3-dipropyl-8-cyclopentylxanthine | [no description available] | medium | 1 | 0 | oxopurine | adenosine A1 receptor antagonist;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor |
| nsc-267703 | [no description available] | medium | 1 | 0 | anthracycline | |
| dactinomycin | [no description available] | medium | 1 | 0 | cyclodepsipeptide | |
| 1-aminoindan-1,5-dicarboxylic acid | [no description available] | medium | 1 | 0 | | |
| amodiaquine | [no description available] | medium | 1 | 0 | aminoquinoline;
organochlorine compound;
phenols;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
drug allergen;
EC 2.1.1.8 (histamine N-methyltransferase) inhibitor;
non-steroidal anti-inflammatory drug;
prodrug |
| astemizole | [no description available] | medium | 1 | 0 | benzimidazoles;
piperidines | anti-allergic agent;
anticoronaviral agent;
H1-receptor antagonist |
| berberine | [no description available] | medium | 1 | 0 | alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound | antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker |
| chloroquine | [no description available] | medium | 1 | 0 | aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug |
| aricine | [no description available] | medium | 1 | 0 | cinchona alkaloid | |
| clofilium | [no description available] | medium | 1 | 0 | benzenes;
organic amino compound | |
| clotrimazole | [no description available] | medium | 1 | 0 | conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes | antiinfective agent;
environmental contaminant;
xenobiotic |
| dequalinium | [no description available] | medium | 1 | 0 | quinolinium ion | antifungal agent;
antineoplastic agent;
antiseptic drug;
mitochondrial NADH:ubiquinone reductase inhibitor |
| nsc-526417 | [no description available] | medium | 1 | 0 | | |
| gentian violet | [no description available] | medium | 1 | 0 | iminium ion | antibacterial agent;
antifungal agent |
| hexahydrosiladifenidol | [no description available] | medium | 1 | 0 | | |
| mefloquine hydrochloride | [no description available] | medium | 1 | 0 | organofluorine compound;
piperidines;
quinolines;
secondary alcohol | |
| moclobemide | [no description available] | medium | 1 | 0 | benzamides;
monochlorobenzenes;
morpholines | antidepressant;
environmental contaminant;
xenobiotic |
| n-acetyl-4-nitrophenylserinol | [no description available] | medium | 1 | 0 | | |
| oxiracetam | [no description available] | medium | 1 | 0 | organonitrogen compound;
organooxygen compound | |
| pentamidine | [no description available] | medium | 1 | 0 | aromatic ether;
carboxamidine;
diether | anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic |
| pronethalol | [no description available] | medium | 1 | 0 | naphthalenes | |
| propafenone | [no description available] | medium | 1 | 0 | aromatic ketone;
secondary alcohol;
secondary amino compound | anti-arrhythmia drug |
| pyrimethamine | [no description available] | medium | 1 | 0 | aminopyrimidine;
monochlorobenzenes | antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor |
| scriptaid | [no description available] | medium | 1 | 0 | isoquinolines | |
| 6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone | [no description available] | medium | 1 | 0 | cyclodepsipeptide | |
| cycloheximide | [no description available] | medium | 1 | 0 | antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol | anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor |
| phanquinone | [no description available] | medium | 1 | 0 | orthoquinones | |
| diphenan | [no description available] | medium | 1 | 0 | diarylmethane | |
| 2-phenylacetamide | [no description available] | medium | 1 | 0 | monocarboxylic acid amide | mouse metabolite |
| tetraphenylborate | [no description available] | medium | 1 | 0 | | |
| cycloguanil hydrochloride | [no description available] | medium | 1 | 0 | hydrochloride;
organic molecular entity | |
| cycloguanil | [no description available] | medium | 1 | 0 | triazines | antifolate;
antiinfective agent;
antimalarial;
antiparasitic agent;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor |
| triphenyltetrazolium | [no description available] | medium | 1 | 0 | organic cation | |
| berbamine | [no description available] | medium | 1 | 0 | phenylpropanoid | |
| emetine | [no description available] | medium | 1 | 0 | isoquinoline alkaloid;
pyridoisoquinoline | antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor |
| Berberine chloride (TN) | [no description available] | medium | 1 | 0 | organic molecular entity | |
| 9,10-dimethylanthracene | [no description available] | medium | 1 | 0 | | |
| c 137 | [no description available] | medium | 1 | 0 | | |
| palmatine | [no description available] | medium | 1 | 0 | berberine alkaloid;
organic heterotetracyclic compound | plant metabolite |
| 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine | [no description available] | medium | 1 | 0 | | |
| buquinolate | [no description available] | medium | 1 | 0 | | |
| propranolol glycol | [no description available] | medium | 1 | 0 | | |
| naphthoxybutanolcyclohexylamine | [no description available] | medium | 1 | 0 | | |
| staurosporine | [no description available] | medium | 1 | 0 | indolocarbazole alkaloid;
organic heterooctacyclic compound | apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector |
| propamidine | [no description available] | medium | 1 | 0 | aromatic ether;
guanidines;
polyether | antimicrobial agent;
antiseptic drug |
| neocuproine | [no description available] | medium | 1 | 0 | phenanthrolines | chelator;
copper chelator |
| toxoflavin | [no description available] | medium | 1 | 0 | carbonyl compound;
pyrimidotriazine | antibacterial agent;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite;
toxin;
virulence factor;
Wnt signalling inhibitor |
| plasmenylserine | [no description available] | medium | 1 | 0 | O-phosphoserine | EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor;
EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
| quinocide | [no description available] | medium | 1 | 0 | | |
| 2,2',2''-terpyridine | [no description available] | medium | 1 | 0 | terpyridines | chelator |
| clobetasone butyrate | [no description available] | medium | 1 | 0 | organic molecular entity | |
| cletoquine | [no description available] | medium | 1 | 0 | | |
| jatrorrhizine | [no description available] | medium | 1 | 0 | alkaloid | |
| lycorine | [no description available] | medium | 1 | 0 | indolizidine alkaloid | anticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor |
| bathophenanthroline | [no description available] | medium | 1 | 0 | benzenes;
phenanthrolines | chelator |
| LSM-4272 | [no description available] | medium | 1 | 0 | beta-carbolines | |
| tryptanthrine | [no description available] | medium | 1 | 0 | alkaloid antibiotic;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound | |
| ethylhydrocupreine | [no description available] | medium | 1 | 0 | aromatic ether;
cinchona alkaloid | EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor |
| 2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine | [no description available] | medium | 1 | 0 | | |
| cinchonine | [no description available] | medium | 1 | 0 | (8xi)-cinchonan-9-ol;
cinchona alkaloid | metabolite |
| 7-chloro-4-aminoquinoline | [no description available] | medium | 1 | 0 | aminoquinoline | |
| mmv665852 | [no description available] | medium | 1 | 0 | | |
| 1,3,4,10-Tetrahydro-9(2H)-acridinone | [no description available] | medium | 1 | 0 | acridines | |
| wr 158122 | [no description available] | medium | 1 | 0 | | |
| 10-deazaaminopterin | [no description available] | medium | 1 | 0 | | |
| dihydroergocristine | [no description available] | medium | 1 | 0 | ergot alkaloid | adrenergic antagonist;
vasodilator agent |
| benzamil | [no description available] | medium | 1 | 0 | guanidines;
pyrazines | |
| 3',4'-dichlorobenzamil | [no description available] | medium | 1 | 0 | guanidines;
pyrazines | |
| cleistanthin b | [no description available] | medium | 1 | 0 | beta-D-glucoside;
cleistanthins;
monosaccharide derivative | alpha-adrenergic antagonist;
antihypertensive agent;
diuretic |
| n-acetyltyramine | [no description available] | medium | 1 | 0 | acetamides;
tyramines | animal metabolite;
Aspergillus metabolite;
bacterial metabolite;
marine metabolite;
quorum sensing inhibitor |
| 1,3-di(4-imidazolinophenoxyl)propane | [no description available] | medium | 1 | 0 | | |
| 7h-pyrido(4,3-c)carbazole | [no description available] | medium | 1 | 0 | | |
| imiloxan | [no description available] | medium | 1 | 0 | benzodioxine | |
| cl 246738 | [no description available] | medium | 1 | 0 | | |
| celastrol methyl ester | [no description available] | medium | 1 | 0 | carboxylic ester | |
| epiberberine | [no description available] | medium | 1 | 0 | | |
| 2-phenyl-4-oxohydroquinoline | [no description available] | medium | 1 | 0 | | |
| cypripedin | [no description available] | medium | 1 | 0 | phenanthrol | |
| respinomycin d | [no description available] | medium | 1 | 0 | | |
| acetoxycycloheximide | [no description available] | medium | 1 | 0 | | |
| (R)-Roemerine | [no description available] | medium | 1 | 0 | isoquinoline alkaloid | |
| 2-guanidine-4-methylquinazoline | [no description available] | medium | 1 | 0 | | |
| mensacarcin | [no description available] | medium | 1 | 0 | | |
| puromycin | [no description available] | medium | 1 | 0 | puromycins | antiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor |
| quinidine | [no description available] | medium | 1 | 0 | cinchona alkaloid | alpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker |
| cephaelin | [no description available] | medium | 1 | 0 | pyridoisoquinoline | |
| epothilone b | [no description available] | medium | 1 | 0 | epothilone;
epoxide | antineoplastic agent;
apoptosis inducer;
microtubule-stabilising agent |
| wr-142,490 | [no description available] | medium | 1 | 0 | [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol | antimalarial |
| dactinomycin | [no description available] | medium | 1 | 0 | actinomycin | mutagen |
| 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | [no description available] | medium | 1 | 0 | pyrimidotriazine | |
| jp-1302 | [no description available] | medium | 1 | 0 | | |
| 7-hydroxy-2-methoxy-1,4-phenanthrenedione | [no description available] | medium | 1 | 0 | | |
| cgp 60474 | [no description available] | medium | 1 | 0 | substituted aniline | |
| (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol | [no description available] | medium | 1 | 0 | alkylbenzene | |
| 2-[2-hydroxy-6,7-dimethoxy-4-(4-morpholinyl)-1-naphthalenyl]-N-phenylacetamide | [no description available] | medium | 1 | 0 | naphthols | |
| N4-(3-chlorophenyl)-6-methyl-N2-(phenylmethyl)pyrimidine-2,4-diamine | [no description available] | medium | 1 | 0 | aralkylamine | |
| 2,6-bis(benzimidazol-2-yl)pyridine | [no description available] | medium | 1 | 0 | benzimidazoles | |
| N-[4-(1-azepanyl)phenyl]-2-chloroacetamide | [no description available] | medium | 1 | 0 | anilide | |
| N-(4-methylphenyl)carbamic acid (cyclopentylideneamino) ester | [no description available] | medium | 1 | 0 | toluenes | |
| (2'-(4-aminophenyl)-(2,5'-bi-1h-benzimidazol)-5-amine) | [no description available] | medium | 1 | 0 | benzimidazoles | |
| 1,4,8-trimethyl-12-quinolino[2,3-b]quinolinamine | [no description available] | medium | 1 | 0 | aminoquinoline | |
| 2-furanyl-(4,4,8-trimethyl-1-sulfanylidene-5-dithiolo[3,4-c]quinolinyl)methanone | [no description available] | medium | 1 | 0 | aromatic amide;
heteroarene | |
| 1-(6-methoxy-2,2,4-trimethyl-1-quinolinyl)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thio]ethanone | [no description available] | medium | 1 | 0 | quinolines | |
| stk295900 | [no description available] | medium | 1 | 0 | | |
| 6-(4-methyl-1-piperazinyl)-2-(3,4,5-trimethoxyphenyl)-1H-benzimidazole | [no description available] | medium | 1 | 0 | benzimidazoles | |
| N9-(4-butoxyphenyl)-6,8,10-triazaspiro[4.5]deca-6,9-diene-7,9-diamine | [no description available] | medium | 1 | 0 | aromatic ether | |
| N-[2-[5-(1,3-benzothiazol-2-yl)-3-ethyl-1-phenyl-2-benzimidazol-3-iumyl]ethenyl]-N-methylaniline | [no description available] | medium | 1 | 0 | benzimidazoles | |
| 4-(1-adamantyl)-2-methyl-1,3-thiazole | [no description available] | medium | 1 | 0 | thiazoles | |
| 2-amino-6-[4-(6-chloro-2-pyridinyl)-1-piperazinyl]pyridine-3,5-dicarbonitrile | [no description available] | medium | 1 | 0 | piperazines;
pyridines | |
| 1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-2-methyl-5-(trifluoromethyl)-3-pyrazolyl]urea | [no description available] | medium | 1 | 0 | pyrazoles;
ring assembly | |
| 2-(4,6,7-Trimethyl-2-quinazolinyl)guanidine | [no description available] | medium | 1 | 0 | quinazolines | |
| polysulfide rubber | [no description available] | medium | 1 | 0 | | |
| lch-7749944 | [no description available] | medium | 1 | 0 | | |
| 4-(4-nitrophenyl)-N-prop-2-enyl-1-piperazinecarbothioamide | [no description available] | medium | 1 | 0 | piperazines | |
| zd 6474 | [no description available] | medium | 1 | 0 | aromatic ether;
organobromine compound;
organofluorine compound;
piperidines;
quinazolines;
secondary amine | antineoplastic agent;
tyrosine kinase inhibitor |
| 5-bromo-1-(1-oxopropyl)-N,N-dipropyl-2,3-dihydroindole-7-sulfonamide | [no description available] | medium | 1 | 0 | indoles | |
| N-cyclohexyl-5,6,7,8-tetrahydro-4H-cyclohepta[d]isoxazole-3-carboxamide | [no description available] | medium | 1 | 0 | aromatic amide;
heteroarene | |
| 2-[(3-ethyl-7-methyl-4-oxo-6,8-dihydro-5H-pyrido[2,3]thieno[2,4-b]pyrimidin-2-yl)thio]-N-(2-phenylethyl)acetamide | [no description available] | medium | 1 | 0 | organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound | |
| trichomonacid | [no description available] | medium | 1 | 0 | | |
| N-(4-bromo-3-methylphenyl)-2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | [no description available] | medium | 1 | 0 | triazolopyrimidines | |
| N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-methoxyethyl)-3-oxo-1H-isoindole-4-carboxamide | [no description available] | medium | 1 | 0 | isoindoles | |
| cgp 71683 a | [no description available] | medium | 1 | 0 | naphthalenes;
sulfonic acid derivative | |
| 2-(dimethylaminostyryl)-1-ethylpyridinium | [no description available] | medium | 1 | 0 | pyridinium ion | |
| hydrocortisone acetate, (11beta)-isomer | [no description available] | medium | 1 | 0 | | |
| xib 4035 | [no description available] | medium | 1 | 0 | | |
| 10-hydroxy-3-methyl-8-pentyl-2,4-dihydro-1H-[1]benzopyrano[3,4-c]pyridin-5-one | [no description available] | medium | 1 | 0 | pyridochromene | |
| lumefantrine | [no description available] | medium | 1 | 0 | fluorenes;
monochlorobenzenes;
secondary alcohol;
tertiary amine | antimalarial |
| edatrexate | [no description available] | medium | 1 | 0 | glutamic acid derivative | |
| norketotifen | [no description available] | medium | 1 | 0 | organosulfur heterocyclic compound | |
| aee 788 | [no description available] | medium | 1 | 0 | 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
epidermal growth factor receptor antagonist;
trypanocidal drug |
| tomaymycin | [no description available] | medium | 1 | 0 | tomaymycin | |
| gramicidin a | [no description available] | medium | 1 | 0 | | |
| N-methyl-3-[5-(3-phenylpropyl)-1,3,4-oxadiazol-2-yl]-N-(3-thiophenylmethyl)propanamide | [no description available] | medium | 1 | 0 | benzenes | |
| 1-[amino-[(6-methoxy-4-methyl-2-quinazolinyl)amino]methylidene]-3-phenylurea | [no description available] | medium | 1 | 0 | quinazolines | |
| miltefosine | [no description available] | medium | 1 | 0 | phosphocholines;
phospholipid | anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor |
| thiazoles | [no description available] | medium | 1 | 0 | 1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | |