Page last updated: 2024-09-27

ARFID

An eating or feeding disturbance (e.g., apparent lack of interest in eating or food; avoidance based on the sensory characteristics of food; concern about aversive consequences of eating) as manifested by persistent failure to meet appropriate nutritional and/or energy needs associated with one (or more) of the following: significant weight loss (or failure to achieve expected weight gain or faltering growth in children); significant nutritional deficiency; dependence on enteral feeding or oral nutritional supplements; or marked interference with psychosocial functioning. (from DSM-V)

Synonyms(3)

Synonym
Avoidant Restrictive Food Intake Disorder
ARFID
Food Neophobia

Research Excerpts

Overview

ExcerptReference
"Avoidant restrictive food intake disorder is rarely reported to cause Wernicke's encephalopathy."( Basouny, N; Khvolis, D; Lee, A; McFarlane-Ferreira, Y; Spigos, J, 2023)

Research

Studies (12)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's1 (8.33)28.8240
2020's11 (91.67)9.53
DrugIndicatedRelationship StrengthStudiesTrials
thiamine0low10
uric acid0low10
sk&f 812970low10
hydroxyzine0low10
risperidone0low20
oxytocin0low10
curcumin0low10
pica0medium31
sch 233900low10
peptide yy0low10
olanzapine0low10

Protein Targets (378)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Ferritin light chain1001
Chain A, Cruzipain1001
Luciferase2002
interleukin 81001
acetylcholinesterase2002
Nrf21001
thioredoxin reductase3003
15-lipoxygenase, partial2002
pregnane X receptor1001
phosphopantetheinyl transferase2002
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma2002
SMAD family member 21001
ATAD5 protein, partial1001
USP1 protein, partial2002
GLS protein4004
SMAD family member 31001
TDP1 protein6006
GLI family zinc finger 32002
Microtubule-associated protein tau1001
alkaline phosphatase, intestinal0101
AR protein2002
thioredoxin glutathione reductase1001
Smad32002
apical membrane antigen 1, AMA11001
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
PINK11001
thyroid stimulating hormone receptor3003
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor1001
EWS/FLI fusion protein1002
glucocorticoid receptor [Homo sapiens]2002
retinoic acid nuclear receptor alpha variant 11001
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha3003
farnesoid X nuclear receptor1001
pregnane X nuclear receptor1001
estrogen nuclear receptor alpha3003
glucocerebrosidase1001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
toll-like receptor 90101
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
caspase-31001
IDH11001
euchromatic histone-lysine N-methyltransferase 23003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
TPA: protein transporter TIM100101
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
thyroid stimulating hormone receptor2002
activating transcription factor 61001
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x2002
lysosomal alpha-glucosidase preproprotein2002
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
perilipin-50101
vitamin D3 receptor isoform VDRA3003
intestinal alkaline phosphatase precursor0101
thyroid hormone receptor beta isoform a1001
perilipin-10101
potassium voltage-gated channel subfamily H member 2 isoform d2002
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 23003
heat shock protein beta-11001
huntingtin isoform 21001
importin subunit beta-1 isoform 11001
pyruvate kinase PKM isoform a1001
DNA polymerase beta1001
mitogen-activated protein kinase 12002
nuclear factor NF-kappa-B p105 subunit isoform 11001
flap endonuclease 11001
snurportin-11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 11001
geminin2002
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA polymerase kappa isoform 11001
peripheral myelin protein 222002
cytochrome P450 3A4 isoform 11001
muscleblind-like protein 1 isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
alkaline phosphatase, germ cell type preproprotein0101
caspase-1 isoform alpha precursor1001
hypothetical protein SA14220101
lethal factor (plasmid)2002
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
lamin isoform A-delta102002
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi1001
Prostaglandin E synthase0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histone deacetylase 30101
Acetylcholinesterase0101
Lysine-specific histone demethylase 1A0101
Voltage-dependent calcium channel gamma-2 subunit2002
D-amino-acid oxidase0101
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Cellular tumor antigen p532002
Amyloid-beta precursor protein0102
Integrin beta-31001
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Prostaglandin G/H synthase 10101
Cholinesterase0101
Heme oxygenase 1 0101
Integrin alpha-IIb1001
Glutathione S-transferase P0101
Polyunsaturated fatty acid 5-lipoxygenase0101
60 kDa chaperonin0101
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0123
Microtubule-associated protein tau0102
60 kDa heat shock protein, mitochondrial0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tissue factor0101
Tyrosinase0101
Aminopeptidase N0101
Aminopeptidase N0101
Gamma-aminobutyric acid receptor subunit beta-11001
Alpha-1B adrenergic receptor0404
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0101
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Glutamate receptor 22002
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Amine oxidase [flavin-containing] A0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Acetylcholinesterase0101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Heme oxygenase 20101
Alpha-1D adrenergic receptor0404
Amine oxidase [flavin-containing] B0202
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Proteasome subunit beta type-50101
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Prostaglandin G/H synthase 20101
17-beta-hydroxysteroid dehydrogenase type 20101
Alpha-synuclein1113
Alpha-1A adrenergic receptor0404
Histamine H2 receptor1002
Glycogen synthase kinase-3 beta0101
Nuclear receptor ROR-gamma1001
Caspase-71001
Histone deacetylase 40101
Beta-secretase 10101
10 kDa heat shock protein, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Guanine nucleotide-binding protein G1001
Gamma-aminobutyric acid receptor subunit beta-21001
Cholinesterase0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
TAR DNA-binding protein 431001
Serine/threonine-protein kinase PAK 10101
Histone deacetylase 10202
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0011
Nuclear factor erythroid 2-related factor 20011
Thiosulfate sulfurtransferase0101
Thioredoxin reductase 1, cytoplasmic0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Thioredoxin reductase 30101
Sortase A0101
Histone deacetylase 70101
GABA theta subunit1001
Histone deacetylase 20202
CREB-binding protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
NACHT, LRR and PYD domains-containing protein 3 0101
ATPase family AAA domain-containing protein 51001
Ataxin-22002
Histone deacetylase 80202
Gamma-aminobutyric acid receptor subunit epsilon1001
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10202
Histone deacetylase 60101
Histone deacetylase 90101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Histone deacetylase 50101
Lymphocyte antigen 960011
Beta lactamase (plasmid)0101
cytochrome P450 2D62002
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Bile salt export pump0303
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
D(2) dopamine receptor0707
5-hydroxytryptamine receptor 2A0505
Histamine H1 receptor0516
Spike glycoprotein3014
Angiotensin-converting enzyme 2 0011
Histamine H4 receptor0101
5-hydroxytryptamine receptor 3E0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
FAD-linked sulfhydryl oxidase ALR0001
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
5-hydroxytryptamine receptor 40404
5-hydroxytryptamine receptor 3B0101
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40303
ATP-dependent translocase ABCB10002
Cytochrome P450 3A40202
5-hydroxytryptamine receptor 1A0235
5-hydroxytryptamine receptor 2C0505
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0404
Muscarinic acetylcholine receptor M10213
Glucose-6-phosphate 1-dehydrogenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Angiotensin-converting enzyme0303
5-hydroxytryptamine receptor 2A0505
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0404
D0406
D(3) dopamine receptor0303
5-hydroxytryptamine receptor 1A0303
Alpha-2B adrenergic receptor0202
Muscarinic acetylcholine receptor M30404
D(1A) dopamine receptor0718
D(4) dopamine receptor0303
Alpha-2C adrenergic receptor0202
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0202
Sodium-dependent noradrenaline transporter 0101
Adenosine receptor A10101
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2C0404
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 2B0505
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0303
5-hydroxytryptamine receptor 70202
Alpha-1A adrenergic receptor0303
Alpha-1B adrenergic receptor0202
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60303
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
D(2) dopamine receptor0607
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
Potassium voltage-gated channel subfamily H member 20505
Sigma non-opioid intracellular receptor 10101
Transporter0202
Nuclear receptor subfamily 3 group C member 3 0303
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
Canalicular multispecific organic anion transporter 10202
Transporter0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
cytochrome P450 2D6 isoform 12002
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C19 precursor1001
survival motor neuron protein isoform d2002
muscarinic acetylcholine receptor M11001
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Albumin0011
Cytochrome P450 2D60101
Beta-1 adrenergic receptor0101
Glycine receptor subunit alpha-10011
Sodium-dependent dopamine transporter0101
Histamine H2 receptor0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
5-hydroxytryptamine receptor 1A0101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Histamine H3 receptor0101
dopamine D1 receptor2002
regulator of G-protein signaling 42002
beta-2 adrenergic receptor1001
D(1A) dopamine receptor2002
Adenylate cyclase type 60101
Adenylate cyclase type 3 0101
Adenylate cyclase type 90101
Adenylate cyclase type 50101
D(1B) dopamine receptor0213
D(1) dopamine receptor0101
Adenylate cyclase type 80101
D(1A) dopamine receptor0101
Adenylate cyclase type 70101
Neuronal acetylcholine receptor subunit alpha-70101
Adenylate cyclase type 20101
Adenylate cyclase type 10101
D0101
Adenylate cyclase type 40101
D0101
Sigma non-opioid intracellular receptor 10101
glp-1 receptor, partial1001
DNA polymerase III, partial1001
hypothetical protein, conserved1001
serine/threonine-protein kinase mTOR isoform 11001
ATP-dependent phosphofructokinase1001
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
cytochrome P450 family 3 subfamily A polypeptide 41001
Solute carrier family 22 member 1 0102
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 60101
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 22 member 60001
Solute carrier family 22 member 80101
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]