Page last updated: 2024-11-13

bm-1197

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Description

BM-1197: inhibits both Bcl-xL and Bcl-2; has antineoplastic activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	60204010
CHEMBL ID	4085804
SCHEMBL ID	15892215
MeSH ID	M000608728

Synonyms (10)

Synonym
SCHEMBL15892215
CS-0079466
bm-1197
HY-120882
n-[4-[4-[3-[2-(4-chlorophenyl)-5-methyl-4-methylsulfonyl-1-propan-2-ylpyrrol-3-yl]-5-fluorophenyl]piperazin-1-yl]phenyl]-4-[[(2r)-4-(4-hydroxypiperidin-1-yl)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)benzenesulfonamide
dmkvqmfonhhnmz-huesyalosa-n
CHEMBL4085804 ,
bdbm50266959
1391107-89-3
AKOS040756719

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Apoptosis regulator Bcl-2	Homo sapiens (human)	Ki	0.0009	0.0000	0.1901	2.9000	AID1483485; AID1599454; AID1853840
Bcl-2-like protein 1	Homo sapiens (human)	Ki	0.0010	0.0000	0.4581	9.0000	AID1483486; AID1599455; AID1853841
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (154)

Process	via Protein(s)	Taxonomy
protein polyubiquitination	Apoptosis regulator Bcl-2	Homo sapiens (human)
apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptors	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to xenobiotic stimulus	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to toxic substance	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of cell growth	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to cytokine	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of neuron apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of calcium ion transport	Apoptosis regulator Bcl-2	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Apoptosis regulator Bcl-2	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Apoptosis regulator Bcl-2	Homo sapiens (human)
ossification	Apoptosis regulator Bcl-2	Homo sapiens (human)
ovarian follicle development	Apoptosis regulator Bcl-2	Homo sapiens (human)
metanephros development	Apoptosis regulator Bcl-2	Homo sapiens (human)
branching involved in ureteric bud morphogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
behavioral fear response	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell homeostasis	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
release of cytochrome c from mitochondria	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of cell-matrix adhesion	Apoptosis regulator Bcl-2	Homo sapiens (human)
lymphoid progenitor cell differentiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell lineage commitment	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of B cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to ischemia	Apoptosis regulator Bcl-2	Homo sapiens (human)
renal system process	Apoptosis regulator Bcl-2	Homo sapiens (human)
melanin metabolic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of nitrogen utilization	Apoptosis regulator Bcl-2	Homo sapiens (human)
autophagy	Apoptosis regulator Bcl-2	Homo sapiens (human)
humoral immune response	Apoptosis regulator Bcl-2	Homo sapiens (human)
DNA damage response	Apoptosis regulator Bcl-2	Homo sapiens (human)
actin filament organization	Apoptosis regulator Bcl-2	Homo sapiens (human)
axonogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
female pregnancy	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of cell population proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
male gonad development	Apoptosis regulator Bcl-2	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to oxidative stress	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to radiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to xenobiotic stimulus	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to toxic substance	Apoptosis regulator Bcl-2	Homo sapiens (human)
post-embryonic development	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to iron ion	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to UV-B	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to gamma radiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of gene expression	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of autophagy	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of calcium ion transport into cytosol	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of glycoprotein biosynthetic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
mesenchymal cell development	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of neuron maturation	Apoptosis regulator Bcl-2	Homo sapiens (human)
smooth muscle cell migration	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of smooth muscle cell migration	Apoptosis regulator Bcl-2	Homo sapiens (human)
cochlear nucleus development	Apoptosis regulator Bcl-2	Homo sapiens (human)
gland morphogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of transmembrane transporter activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of ossification	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of cell growth	Apoptosis regulator Bcl-2	Homo sapiens (human)
melanocyte differentiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of cell migration	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of B cell proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
hair follicle morphogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
axon regeneration	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of protein stability	Apoptosis regulator Bcl-2	Homo sapiens (human)
endoplasmic reticulum calcium ion homeostasis	Apoptosis regulator Bcl-2	Homo sapiens (human)
glomerulus development	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of cellular pH reduction	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of protein localization	Apoptosis regulator Bcl-2	Homo sapiens (human)
myeloid cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of myeloid cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
T cell differentiation in thymus	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Apoptosis regulator Bcl-2	Homo sapiens (human)
osteoblast proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of osteoblast proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to nicotine	Apoptosis regulator Bcl-2	Homo sapiens (human)
organ growth	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of multicellular organism growth	Apoptosis regulator Bcl-2	Homo sapiens (human)
cellular response to glucose starvation	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to hydrogen peroxide	Apoptosis regulator Bcl-2	Homo sapiens (human)
neuron maturation	Apoptosis regulator Bcl-2	Homo sapiens (human)
T cell homeostasis	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
CD8-positive, alpha-beta T cell lineage commitment	Apoptosis regulator Bcl-2	Homo sapiens (human)
ear development	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of viral genome replication	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of melanocyte differentiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
retinal cell programmed cell death	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of retinal cell programmed cell death	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of mitochondrial membrane permeability	Apoptosis regulator Bcl-2	Homo sapiens (human)
focal adhesion assembly	Apoptosis regulator Bcl-2	Homo sapiens (human)
spleen development	Apoptosis regulator Bcl-2	Homo sapiens (human)
thymus development	Apoptosis regulator Bcl-2	Homo sapiens (human)
digestive tract morphogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
oocyte development	Apoptosis regulator Bcl-2	Homo sapiens (human)
skeletal muscle fiber development	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of skeletal muscle fiber development	Apoptosis regulator Bcl-2	Homo sapiens (human)
pigment granule organization	Apoptosis regulator Bcl-2	Homo sapiens (human)
stem cell development	Apoptosis regulator Bcl-2	Homo sapiens (human)
homeostasis of number of cells within a tissue	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell receptor signaling pathway	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to glucocorticoid	Apoptosis regulator Bcl-2	Homo sapiens (human)
neuron apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
defense response to virus	Apoptosis regulator Bcl-2	Homo sapiens (human)
establishment of localization in cell	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of mitochondrial membrane potential	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of mitochondrial depolarization	Apoptosis regulator Bcl-2	Homo sapiens (human)
hematopoietic stem cell differentiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
calcium ion transport into cytosol	Apoptosis regulator Bcl-2	Homo sapiens (human)
T cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of T cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
cellular response to organic substance	Apoptosis regulator Bcl-2	Homo sapiens (human)
cellular response to hypoxia	Apoptosis regulator Bcl-2	Homo sapiens (human)
reactive oxygen species metabolic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
dendritic cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
motor neuron apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
cell-cell adhesion	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Apoptosis regulator Bcl-2	Homo sapiens (human)
epithelial cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of epithelial cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of G1/S transition of mitotic cell cycle	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of dendritic cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of motor neuron apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of anoikis	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of apoptotic signaling pathway	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Apoptosis regulator Bcl-2	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Apoptosis regulator Bcl-2	Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligand	Apoptosis regulator Bcl-2	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to cytokine	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Bcl-2-like protein 1	Homo sapiens (human)
ovarian follicle development	Bcl-2-like protein 1	Homo sapiens (human)
in utero embryonic development	Bcl-2-like protein 1	Homo sapiens (human)
release of cytochrome c from mitochondria	Bcl-2-like protein 1	Homo sapiens (human)
endocytosis	Bcl-2-like protein 1	Homo sapiens (human)
germ cell development	Bcl-2-like protein 1	Homo sapiens (human)
spermatogenesis	Bcl-2-like protein 1	Homo sapiens (human)
male gonad development	Bcl-2-like protein 1	Homo sapiens (human)
apoptotic mitochondrial changes	Bcl-2-like protein 1	Homo sapiens (human)
fertilization	Bcl-2-like protein 1	Homo sapiens (human)
regulation of cytokinesis	Bcl-2-like protein 1	Homo sapiens (human)
positive regulation of mononuclear cell proliferation	Bcl-2-like protein 1	Homo sapiens (human)
ectopic germ cell programmed cell death	Bcl-2-like protein 1	Homo sapiens (human)
regulation of growth	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of neuron apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
dendritic cell proliferation	Bcl-2-like protein 1	Homo sapiens (human)
response to cycloheximide	Bcl-2-like protein 1	Homo sapiens (human)
regulation of mitochondrial membrane permeability	Bcl-2-like protein 1	Homo sapiens (human)
epithelial cell proliferation	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of developmental process	Bcl-2-like protein 1	Homo sapiens (human)
neuron apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
defense response to virus	Bcl-2-like protein 1	Homo sapiens (human)
regulation of mitochondrial membrane potential	Bcl-2-like protein 1	Homo sapiens (human)
cellular response to amino acid stimulus	Bcl-2-like protein 1	Homo sapiens (human)
cellular response to alkaloid	Bcl-2-like protein 1	Homo sapiens (human)
cellular response to gamma radiation	Bcl-2-like protein 1	Homo sapiens (human)
apoptotic process in bone marrow cell	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of release of cytochrome c from mitochondria	Bcl-2-like protein 1	Homo sapiens (human)
dendritic cell apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
hepatocyte apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of execution phase of apoptosis	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of protein localization to plasma membrane	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of reproductive process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of dendritic cell apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Bcl-2-like protein 1	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Bcl-2-like protein 1	Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligand	Bcl-2-like protein 1	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (14)

Process	via Protein(s)	Taxonomy
protease binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
protein binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
channel activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
channel inhibitor activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
ubiquitin protein ligase binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
identical protein binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
sequence-specific DNA binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
protein heterodimerization activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
BH3 domain binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
protein phosphatase 2A binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
molecular adaptor activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
DNA-binding transcription factor binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
BH domain binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
protein binding	Bcl-2-like protein 1	Homo sapiens (human)
protein kinase binding	Bcl-2-like protein 1	Homo sapiens (human)
identical protein binding	Bcl-2-like protein 1	Homo sapiens (human)
BH3 domain binding	Bcl-2-like protein 1	Homo sapiens (human)
BH domain binding	Bcl-2-like protein 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (18)

Process	via Protein(s)	Taxonomy
mitochondrial outer membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
endoplasmic reticulum membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
nucleus	Apoptosis regulator Bcl-2	Homo sapiens (human)
cytoplasm	Apoptosis regulator Bcl-2	Homo sapiens (human)
mitochondrion	Apoptosis regulator Bcl-2	Homo sapiens (human)
mitochondrial outer membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
endoplasmic reticulum	Apoptosis regulator Bcl-2	Homo sapiens (human)
cytosol	Apoptosis regulator Bcl-2	Homo sapiens (human)
membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
nuclear membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
myelin sheath	Apoptosis regulator Bcl-2	Homo sapiens (human)
BAD-BCL-2 complex	Apoptosis regulator Bcl-2	Homo sapiens (human)
protein-containing complex	Apoptosis regulator Bcl-2	Homo sapiens (human)
pore complex	Apoptosis regulator Bcl-2	Homo sapiens (human)
cytoplasm	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrion	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrial outer membrane	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrial inner membrane	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrial matrix	Bcl-2-like protein 1	Homo sapiens (human)
endoplasmic reticulum	Bcl-2-like protein 1	Homo sapiens (human)
centrosome	Bcl-2-like protein 1	Homo sapiens (human)
cytosol	Bcl-2-like protein 1	Homo sapiens (human)
synaptic vesicle membrane	Bcl-2-like protein 1	Homo sapiens (human)
nuclear membrane	Bcl-2-like protein 1	Homo sapiens (human)
Bcl-2 family protein complex	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrial outer membrane	Bcl-2-like protein 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID1483486	Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay	2017	Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3	Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.
AID1853841	Binding affinity to Bcl-xL (unknown origin) assessed as inhibition constant by fluorescence polarization assay	2022	European journal of medicinal chemistry, Mar-15, Volume: 232	Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment.
AID1483487	Selectivity ratio of compound effect for Bcl-2 (unknown origin) to compound effect for Mcl-1 (unknown origin)	2017	Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3	Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.
AID1483485	Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay	2017	Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3	Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.
AID1483488	Selectivity ratio of compound effect for Bcl-xL (unknown origin) to compound effect for Mcl-1 (unknown origin)	2017	Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3	Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.
AID1599455	Inhibition of Bcl-xL (unknown origin)	2019	European journal of medicinal chemistry, Sep-01, Volume: 177	The chemical biology of apoptosis: Revisited after 17 years.
AID1853840	Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant by fluorescence polarization assay	2022	European journal of medicinal chemistry, Mar-15, Volume: 232	Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment.
AID1599454	Inhibition of Bcl2 (unknown origin)	2019	European journal of medicinal chemistry, Sep-01, Volume: 177	The chemical biology of apoptosis: Revisited after 17 years.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (85.71)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.12

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.12 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.56 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.12)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (42.86%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (57.14%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hoe 33342 BXI-72: structure in first source	3.31	1	bibenzimidazole; N-methylpiperazine	fluorochrome
gossypol Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.	3.31	1
apogossypol apogossypol: structure in first source	3.31	1
umi-77 UMI-77: an Mcl-1 inhibitor; structure in first source	3.31	1
abt-737 [no description available]	4.19	2	aromatic amine; aryl sulfide; biphenyls; C-nitro compound; monochlorobenzenes; N-arylpiperazine; N-sulfonylcarboxamide; secondary amino compound; tertiary amino compound	anti-allergic agent; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.51	2
marinopyrrole a marinopyrrole A: antibiotic from a marine Streptomyces sp.; structure in first source. (-)-marinopyrrole A : A member of the class of pyrroles that is 1'H-1,3'-bipyrrole substituted by four chloro groups at positions 4, 4', 5 and 5' and two 2-hydroxybenzoyl moieties at positions 2 and 2'. It is isolated from Streptomyces sp.CNQ-418 and exhibits cytotoxic and antibacterial activities.	4.19	2	aromatic ketone; organochlorine compound; phenols; pyrroles	antibacterial agent; antimicrobial agent; antineoplastic agent; bacterial metabolite; marine metabolite
navitoclax [no description available]	3.64	2	aryl sulfide; monochlorobenzenes; morpholines; N-sulfonylcarboxamide; organofluorine compound; piperazines; secondary amino compound; sulfone; tertiary amino compound	antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor
abt-199 venetoclax: A BCL-2 inhibitor with antineoplastic activity that is used in the treatment of CHRONIC LYMPHOCYTIC LEUKEMIA associated with chromosome 17p deletion; structure in first source.. venetoclax : A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.	4.86	3	aromatic ether; C-nitro compound; monochlorobenzenes; N-alkylpiperazine; N-arylpiperazine; N-sulfonylcarboxamide; oxanes; pyrrolopyridine	antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor
jy-1-106 JY-1-106: a BH3 alpha-helix mimetic that functions as a pan-Bcl-2 inhibitor; structure in first source	4.19	2
a-1155463 A-1155463: a Bcl-X(L) inhibitor; structure in first source	3.51	1
a-1331852 A-1331852: a Bcl-X(L) inhibitor; structure in first source	3.31	1
BDA-366 BDA-366: has antineoplastic activity; binds Bcl-2 protein; structure in first source. BDA-366 : A member of the class of anthraquinone that is 1,4-diamino-9,10-anthraquinone in which the two amino groups are carrying 3-(diethylamino)-2-hydroxypropyl and (oxiran-2-yl)methyl substituents. It exhibits anti-cancer properties.	3.51	1	anthraquinone; epoxide; secondary alcohol; secondary amino compound; tertiary amino compound	antineoplastic agent; apoptosis inducer
apogossypolone apogossypolone: has antineoplastic activity; structure in first source	3.31	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	4.62	3
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	4.62	3
Germinoblastoma [description not available]	2.21	1
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	7.21	1
Cancer of Lung [description not available]	2.1	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.1	1
Colorectal Cancer [description not available]	7.11	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.11	1
Adenocystic Carcinoma [description not available]	2.11	1
Experimental Neoplasms [description not available]	2.11	1
Cancer of Salivary Gland [description not available]	2.11	1
Local Neoplasm Recurrence [description not available]	2.11	1
Carcinoma, Adenoid Cystic Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)	2.11	1
Salivary Gland Neoplasms Tumors or cancer of the SALIVARY GLANDS.	2.11	1

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