pore complex

Definition

Target type: cellularcomponent

A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. [ISBN:0198506732]

The nuclear pore complex (NPC) is a large, intricate protein structure embedded in the nuclear envelope, acting as the sole conduit for transport between the nucleus and cytoplasm. This intricate structure is composed of multiple proteins called nucleoporins (Nups), which assemble into a symmetrical ring-shaped structure that spans the nuclear envelope. The NPC comprises several distinct components:

**1. Central Transporter Channel:** This channel is the core of the NPC and is lined by FG-repeat nucleoporins, which exhibit a characteristic "fuzzy" structure. These proteins play a crucial role in regulating the transport of molecules through the NPC.

**2. Nuclear Basket:** Situated on the nuclear side of the NPC, the nuclear basket is composed of a network of filaments that extend into the nucleoplasm. This structure is thought to function in anchoring the NPC to the nuclear lamina and facilitating the translocation of molecules into the nucleus.

**3. Cytoplasmic Filaments:** Located on the cytoplasmic side of the NPC, the cytoplasmic filaments extend into the cytoplasm. These filaments are believed to be involved in the capture and delivery of cargo molecules to the NPC.

**4. Transmembrane Nups:** These nucleoporins span the nuclear envelope and anchor the NPC to the nuclear membrane. They contribute to the structural integrity of the NPC and its interaction with the nuclear envelope.

**5. Scaffold Nups:** These nucleoporins form the structural framework of the NPC, providing a platform for the assembly of other components. They play a crucial role in maintaining the overall architecture of the NPC.

These components work in concert to ensure selective and regulated transport of molecules across the nuclear envelope, maintaining the integrity and functionality of the nucleus.'
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Proteins (5)

Compounds (40)