peptidyl-lysine propionylation

Definition

Target type: biologicalprocess

The propionylation of peptidyl-lysine. [PMID:17267393]

Peptidyl-lysine propionylation is a post-translational modification (PTM) where a propionyl group (CH3CH2CO-) is attached to the ε-amino group of a lysine residue within a protein. This modification can alter the structure and function of the protein, potentially influencing its interactions with other molecules, its stability, and its activity.

**Mechanism:**

Propionylation is typically catalyzed by enzymes known as propionyltransferases. These enzymes utilize propionyl-CoA as a donor of the propionyl group, which is then transferred to the lysine residue on the target protein. The process is often influenced by cellular conditions, such as the availability of propionyl-CoA and the presence of specific propionyltransferases.

**Biological Significance:**

* **Regulation of Protein Function:** Propionylation can modify protein activity by altering its conformation, stability, or interaction with other proteins.
* **Signal Transduction:** This modification can act as a signal for cellular processes, potentially influencing gene expression or cellular signaling pathways.
* **Cellular Stress Response:** Propionylation can be involved in cellular responses to stress conditions, such as nutrient deprivation or oxidative stress.
* **Disease Implications:** Dysregulation of propionylation has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic disorders.

**Methods of Detection:**

Propionylation can be detected using various techniques, including:

* **Mass spectrometry (MS):** This technique can identify and quantify the presence of propionylated lysine residues in proteins.
* **Antibodies:** Specific antibodies can be used to detect propionylated lysine residues in cells or tissues.

**Further Research:**

The field of peptidyl-lysine propionylation is still under active investigation. Research is ongoing to understand the mechanisms, functions, and significance of this modification in various biological contexts.
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Proteins (1)

Compounds (25)