Target type: molecularfunction
Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. [EC:2.3.1.48]
Histone H4 acetyltransferase activity is a crucial molecular function in the regulation of gene expression. This activity involves the transfer of an acetyl group from acetyl coenzyme A (acetyl-CoA) to the ε-amino group of lysine residues in histone H4, a core component of the nucleosome. Acetylation is a post-translational modification that alters the charge of histone tails, reducing their interaction with DNA and leading to a more relaxed chromatin structure. This relaxed structure allows for increased accessibility of DNA to transcription factors, promoting gene expression. Histone H4 acetyltransferase enzymes, also known as HATs, are responsible for catalyzing this acetylation reaction. They belong to a family of enzymes with diverse structures and regulatory mechanisms. HATs play a vital role in various cellular processes, including development, cell cycle regulation, and DNA repair. The specific lysine residues targeted by HATs within histone H4 are often associated with specific regulatory functions, leading to complex interplay in gene expression.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Histone acetyltransferase KAT8 | A histone acetyltransferase KAT8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H7Z6] | Homo sapiens (human) |
| N-alpha-acetyltransferase 50 | An N-alpha-acetyltransferase 50 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZZ1] | Homo sapiens (human) |
| Histone acetyltransferase KAT5 | A histone acetyltransferase KAT5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92993] | Homo sapiens (human) |
| Histone acetyltransferase p300 | A histone acetyltransferase p300 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09472] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 4-aminophenol | 4-aminophenol : An amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group. 4-aminophenol: RN given refers to parent cpd | aminophenol | allergen; metabolite |
| 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole | 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation. | aromatic primary alcohol; furans; indazoles | antineoplastic agent; apoptosis inducer; platelet aggregation inhibitor; soluble guanylate cyclase activator; vasodilator agent |
| 1-nitronaphthalene | 1-nitronaphthalene : A mononitronaphthalene substituted by a nitro group at position 1. 1-nitronaphthalene: RN given refers to cpd with locant for nitro moiety in 1 position mononitronaphthalene : A nitronaphthalene carrying a single nitro group at unspecified position. nitronaphthalene : A nitroarene that is naphthalene substituted by at least one nitro group. | mononitronaphthalene | environmental contaminant; mouse metabolite |
| phenylhydrazine | phenylhydrazines | xenobiotic | |
| 4-chloroaniline | 4-chloroaniline : A chloroaniline in which the chloro atom is para to the aniline amino group. 4-chloroaniline: RN given refers to parent cpd; structure | chloroaniline; monochlorobenzenes | |
| 1-naphthylamine | 1-naphthylamine : A naphthylamine that is naphthalene substituted by an amino group at position 1. 1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. naphthylamine : A primary arylamine that is naphthalene substituted by an amino group at unspecified position. | naphthylamine | human xenobiotic metabolite |
| 4-fluoroaniline | 4-fluoroaniline : A primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators. 4-fluoroaniline: chemical intermediate manufactured by the Halex process; RN given refers to parent cpd; structure given in first source | fluoroaniline; primary arylamine | |
| plumbagin | plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively. plumbagin: a superoxide anion generator | hydroxy-1,4-naphthoquinone; phenols | anticoagulant; antineoplastic agent; immunological adjuvant; metabolite |
| palmatine | burasaine: structure in first source | berberine alkaloid; organic heterotetracyclic compound | plant metabolite |
| phenylhydrazine hydrochloride | phenylhydrazine hydrochloride : A hydrochloride resulting from the reaction of equimolar amounts of phenylhydrazine and hydrogen chloride. | hydrochloride | |
| epigallocatechin gallate | (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis) | flavans; gallate ester; polyphenol | antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite |
| 4-fluorobenzylamine | |||
| delphinidin | delphinidin chloride : An anthocyanidin chloride that has delphinidin as the cationic counterpart. Paraffin: A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology. | anthocyanidin chloride | |
| 4-hydroxyquinoline | 4-quinolone : A quinolone that is 1,4-dihydroquinoline substituted by an oxo group at position 4. | monohydroxyquinoline; quinolone | |
| haloprogin | venenatine: RN given for (3beta,16beta,17beta,20alpha)-isomer; structure in first source | ||
| taxodione | taxodione: structure | diterpenoid | |
| coenzyme a | adenosine 3',5'-bisphosphate | coenzyme; Escherichia coli metabolite; mouse metabolite | |
| c.i. direct red 23 | C.I. Direct Red 23: azo dye; structure in first source | ||
| n-(4-(7-diethylamino-4-methylcoumarin-3-yl)phenyl)maleimide | 7-diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin : A member of the class of coumarins that is 2H-chromen-2-one substituted by 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl, methyl, and diethylamino groups at positions 3, 4 and 7, respectively. It is a thiol-reactive fluorescent dye. N-(4-(7-diethylamino-4-methylcoumarin-3-yl)phenyl)maleimide: structure given in first source | benzenes; coumarins; maleimides; tertiary amino compound | fluorescent dye |
| anacardic acid | anacardic acid : A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities. anacardic acid: isolated from Anacardium occidentale; monophenol monooxygenase inhibitor | hydroxy monocarboxylic acid; hydroxybenzoic acid | anti-inflammatory agent; antibacterial agent; anticoronaviral agent; apoptosis inducer; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; neuroprotective agent; plant metabolite |
| acetyl coenzyme a | Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. | acyl-CoA | acyl donor; coenzyme; effector; fundamental metabolite |
| curcumin | curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes. | aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol | anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger |
| umi-77 | UMI-77: an Mcl-1 inhibitor; structure in first source | ||
| cyqualon | cyclovalone: is a synthetic curcumin derivative; structure in first source | ||
| guttiferone e | guttiferone E: isolated from the fruits of Garcinia pyrifera collected in Malaysia; structure in first source | ||
| 2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid | hydroxybenzoic acid | ||
| 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)- | organonitrogen heterocyclic compound; organosulfur heterocyclic compound | ||
| chetomin | |||
| cambogin | isogarcinol: has immunosuppresant activity; isolated from Garcinia mangostana; structure in first source | ||
| 3,4-dimethoxy-n-((2,2-dimethyl-2h-chromen-6-yl)methyl)-n-phenylbenzenesulfonamide | 3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide: has antineoplastic activity; structure in first source | ||
| jq1 compound | carboxylic ester; organochlorine compound; tert-butyl ester; thienotriazolodiazepine | angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; bromodomain-containing protein 4 inhibitor; cardioprotective agent; ferroptosis inducer | |
| gsk525762a | molibresib: mimicks acetylated histones; structure in first source | benzodiazepine | |
| i-bet726 | |||
| 1,2-bis(isothiazol-5-yl)disulfane | 1,2-bis(isothiazol-5-yl)disulfane: structure in first source |