histone H3K122 acetyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122). [PMID:23415232]

Histone H3K122 acetyltransferase activity refers to the enzymatic ability to transfer an acetyl group from acetyl-CoA to the lysine residue at position 122 of histone H3. This acetylation event plays a crucial role in regulating gene expression by altering chromatin structure and accessibility. Specifically, acetylation of histone H3 lysine 122 (H3K122ac) is associated with active transcription and is often found in regions of the genome where genes are being transcribed. The mechanism involves the enzyme (histone H3K122 acetyltransferase) binding to the histone H3 tail and catalyzing the transfer of an acetyl group from acetyl-CoA to the epsilon-amino group of lysine 122. This modification neutralizes the positive charge of lysine, reducing the interaction between histone tails and DNA, and promoting a more open chromatin conformation. This open conformation allows transcription factors and other regulatory proteins to access the DNA and initiate gene expression. Furthermore, H3K122 acetylation can also recruit other chromatin-modifying enzymes, further contributing to the regulation of gene expression. In summary, histone H3K122 acetyltransferase activity is a critical component of the cellular machinery that regulates gene expression through modifications to chromatin structure.'
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Proteins (1)

Compounds (25)