Compounds > mecarbam
Page last updated: 2024-12-05

mecarbam

Description

mecarbam : An organic thiophosphate that is O,O-diethyl hydrogen phosphorodithioate in which the hydrogen attached to a sulfur is replaced by a 2-[(ethoxycarbonyl)(methyl)amino]-2-oxoethyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID17434
CHEMBL ID1417951
CHEBI ID38718
SCHEMBL ID117570
MeSH IDM0153049

Synonyms (87)

Synonym
mecarbam [bsi:iso]
s-((ethoxycarbonyl)methylcarbamoyl)methyl o,o-diethyl phosphorodithioate
p 474
hsdb 1579
ethyl (mercaptoacetyl)methylcarbamate s-ester with o,o-diethyl phosphorodithioate
o,o-diethyl s-(n-ethoxycarbonyl-n-methylcarbamoylmethyl)phosphorothiolothionate
o,o-diethyl s-(n-ethoxycarbonyl-n-methylcarbamoylmethyl)phosphorodithioate
marfotoks
brn 1888011
ethyl 6-ethoxy-2-methyl-3-oxo-7-oxa-5-thia-2-aza-6-phosphanonanoate 6-sulfide
murphotox
o,o-diethyl-s-(3-methyl-2,4-dioxo-5-oxa-3-aza-heptyl)-dithiofosfaat [dutch]
s-(n-ethoxycarbonyl-n-methylcarbamoylmethyl)-diethyl phosphorodithioate
ms 1143
carbamic acid, (mercaptoacetyl)methyl-, ethyl ester, s-ester with o,o- diethyl phosphorodithioate
pestan
pennsalt td-72
o,o-dietil-s-(n-etossi-carbonil-n-metil-carbamoil-metil)-ditiofosfato [italian]
o,o-diaethyl-s-(3-methyl-2,4-dioxo-5-oxa-3-aza-heptyl)-dithiophosphat [german]
afos
td 72
caswell no. 340
carbamic acid, (mercaptoacetyl)methyl-, ethyl ester, o,o-diethyl phosphorodithioate
phosphorodithioic acid, o,o-diethyl ester, s-ester with ethyl (mercaptoacetyl)methylcarbamate
ethyl(((diethoxyphosphinothioyl)thio)acetyl)methylcarbamate
7-oxa-5-thia-2-aza-6-phosphanonanoic acid, 6-ethoxy-2-methyl-3-oxo-, ethyl ester, 6-sulfide
mercarbam
ethyl n-(diethoxythiophosphorylthio)acetyl-n-methylcarbamate
o,o-diethyl s-(n-ethoxycarbonyl-n-methylcarbamoylmethyl) phosphorothiolothionate
o,o-diethyl s-(n-methyl-n-carboethoxycarbamoylmethyl) dithiophosphate
n-ethoxycarbonyl-n-methylcarbamoylmethyl o,o-diethyl phosphorodithioate
murfotox
ms 1053
mecarbame [iso-french]
epa pesticide chemical code 340100
ethyl (diethoxyphosphinothioylthio)acetyl(methyl)carbamate
dithiophosphate de o,o-diethyle et de s-n-methyl n-carboethoxy carbamoylmethyle [french]
mecarbame
einecs 219-993-9
s-(n-ethoxycarbonyl-n-methylcarbamoylmethyl) o,o-diethyl phosphorodithioate
o,o-diethyl s-(((ethoxycarbonyl)methylcarbamoyl)methyl) phosphorodithioate
criotox
o,o-diethyl s-(n-methyl-n-carboethoxycarbamoylmethyl)dithiophosphate
mc 474
NCGC00166159-01
o,o-diethyl s-(n-ethoxycarbonyl-n-methylcarbamoylmethyl) phosphorodithioate
ethyl {[(diethoxyphosphorothioyl)sulfanyl]acetyl}methylcarbamate
mecarbam
CHEBI:38718 ,
2595-54-2
ethyl n-(2-diethoxyphosphinothioylsulfanylacetyl)-n-methylcarbamate
C18661
unii-u6n6869c7z
o,o-diaethyl-s-(3-methyl-2,4-dioxo-5-oxa-3-aza-heptyl)-dithiophosphat
o,o-diethyl-s-(3-methyl-2,4-dioxo-5-oxa-3-aza-heptyl)-dithiofosfaat
u6n6869c7z ,
dithiophosphate de o,o-diethyle et de s-n-methyl n-carboethoxy carbamoylmethyle
o,o-dietil-s-(n-etossi-carbonil-n-metil-carbamoil-metil)-ditiofosfato
NCGC00255735-01
cas-2595-54-2
tox21_302005
dtxsid0042117 ,
dtxcid8022117
ms-1143
carbamic acid, (mercaptoacetyl)methyl-, ethyl ester, s-ester with o,o-diethyl phosphorodithioate
mecarbam [iso]
td-72
mecarbam [hsdb]
SCHEMBL117570
ethyl [(diethoxyphosphorothioyl)sulfanyl]acetyl(methyl)carbamate #
murutox
carbamic acid, (mercaptoacetyl)methyl-, ethyl ester, s-ester with o,o-diethyl phosphorodithioic acid
muratox
pennsalt td 72
KLGMSAOQDHLCOS-UHFFFAOYSA-N
CHEMBL1417951
ethyl n-(2-{[diethoxy(sulfanylidene)-$l^{5}-phosphanyl]sulfanyl}acetyl)-n-methylcarbamate
mecarbam, pestanal(r), analytical standard
mecarbam 10 microg/ml in acetonitrile
ethyl 6-ethoxy-2-methyl-3-oxo-7-oxa-5-thia-2-aza-9-phosphanonanoate 6-sulfide, 9ci
ethyl [[(diethoxyphosphinothioyl)thio]acetyl]methylcarbamate
J-016191
ethyl 2-(diethoxyphosphorothioylthio)acetyl(methyl)carbamate
Q27117958
6-methoxy-indan-1-ylaminehydrochloride
7-oxa-5-thia-2-aza-6-phosphanonanoic acid, 6-ethoxy-2-methyl-3-oxo-,ethyl ester, 6-sulfide
CAA59554
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
EC 3.1.1.7 (acetylcholinesterase) inhibitorAn EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
acaricideA substance used to destroy pests of the subclass Acari (mites and ticks).
agrochemicalAn agrochemical is a substance that is used in agriculture or horticulture.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
organic thiophosphate
organothiophosphate insecticide
carbamate esterAny ester of carbamic acid or its N-substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (10)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
acetylcholinesteraseHomo sapiens (human)Potency56.38130.002541.796015,848.9004AID1347395
phosphopantetheinyl transferaseBacillus subtilisPotency31.62280.141337.9142100.0000AID1490
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency27.63900.001022.650876.6163AID1224838; AID1224839; AID1224893
retinoid X nuclear receptor alphaHomo sapiens (human)Potency54.94100.000817.505159.3239AID1159527
pregnane X nuclear receptorHomo sapiens (human)Potency30.63790.005428.02631,258.9301AID1346982
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency0.12300.001024.504861.6448AID743215
aryl hydrocarbon receptorHomo sapiens (human)Potency15.65570.000723.06741,258.9301AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency54.48270.001723.839378.1014AID743083
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency50.11870.354828.065989.1251AID504847
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency68.58960.000627.21521,122.0200AID743202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (25.00)18.7374
1990's3 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.61 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies3 (60.00%)4.05%
Observational0 (0.00%)0.25%
Other2 (40.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethoate
Dimethoate: An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.. dimethoate : A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.		1.9910monocarboxylic acid amide;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
fenthion
Fenthion: Potent cholinesterase inhibitor used as an insecticide and acaricide.. fenthion : An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen atom of the hydroxy group is replaced by a 3-methyl-4-(methylsulfanyl)phenyl group. It exhibits acaricidal and insecticidal activities.		1.9910organic thiophosphateacaricide;
agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
malathion
Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.		1.9910diester;
ethyl ester;
organic thiophosphate
methidathion
methidathion: widely used on citrus, tobacco, alfalfa, cotton, sorghum & several other crops		1.9910organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
phosphamidon
Phosphamidon: An organophosphate cholinesterase inhibitor that is used as an insecticide.		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Organophosphorus Poisoning
[description not available]		02.8940
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.		01.9910
Organophosphate Poisoning
Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.		02.8940
Coma
A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.		01.9810
Polyneuropathy, Acquired
[description not available]		01.9810
Agricultural Worker Disease
[description not available]		01.9810
Polyneuropathies
Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.		01.9810
Amyotonia Congenita
[description not available]		01.9710
Neuromuscular Diseases
A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.		01.9710
Fetal Death
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.		01.9710
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9710
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