Leber Congenital Amaurosis

A rare degenerative inherited eye disease that appears at birth or in the first few months of life that results in a loss of vision. Not to be confused with LEBER HEREDITARY OPTIC NEUROPATHY, the disease is thought to be caused by abnormal development of PHOTORECEPTOR CELLS in the RETINA, or by the extremely premature degeneration of retinal cells.

Synonym
Leber Congenital Amaurosis

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (1.69)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	45 (76.27)	28.8240
2020's	13 (22.03)	9.53

Drug	Relationship Strength	Studies	Trials
thiamine	low	2	0
hydroxychloroquine	low	1	0
pentobarbital	low	1	0
4-phenylbutyric acid	low	1	0
triiodothyronine	low	1	0
methylprednisolone	low	1	0
zinc phosphate	low	2	0
glutamic acid	low	1	0
fomesafen	low	1	0
lopinavir	low	1	0
darunavir	low	1	0
taurochenodeoxycholic acid	low	2	0
ritonavir	low	1	0
retinol	medium	2	1
tacrolimus	low	1	0
beta-ionone	low	1	0
retinaldehyde	low	7	0
retinol acetate	medium	2	1
methimazole	low	1	0
beta carotene	low	1	0
11-cis-retinal	low	7	0
cysteine	low	2	0
9-cis-retinal	low	3	0
ursodoxicoltaurine	low	2	0
oxadiazoles	low	1	0
ptc 124	low	1	0
nad	low	3	0
phosphatidylcholines	low	1	0
cobicistat	low	1	0
interleukin-8	low	1	0
tubastatin a	low	1	0
muramidase	low	1	0
cyclic gmp	low	4	0
guanosine monophosphate	low	1	0
eye	low	11	0

Protein Targets (533)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Retinaldehyde-binding protein 1	0	0	1	1
Chain A, Retinaldehyde-binding protein 1	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
mitogen-activated protein kinase 1	3	0	0	3
survival motor neuron protein isoform d	2	0	0	2
Histone deacetylase 3	0	3	0	3
Histone deacetylase 4	0	4	0	4
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	4	0	4
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	4	1	6
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Aldo-keto reductase family 1 member B10	0	0	0	4
Aldo-keto reductase family 1 member B1	0	0	0	2
TDP1 protein	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
core protein, partial	0	1	0	1
geminin	7	0	0	7
peripheral myelin protein 22	5	0	0	5
histone acetyltransferase KAT2A isoform 1	2	0	0	2
lamin isoform A-delta10	4	0	0	4
Bile salt export pump	0	8	0	10
Solute carrier organic anion transporter family member 1B3	0	6	0	7
Solute carrier organic anion transporter family member 1B1	0	7	0	8
acetylcholinesterase	5	0	0	5
GLI family zinc finger 3	9	0	0	9
estrogen receptor 2 (ER beta)	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
pregnane X nuclear receptor	12	0	0	12
estrogen nuclear receptor alpha	14	0	0	14
thyroid stimulating hormone receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
thyroid hormone receptor beta isoform 2	9	0	0	9
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 3A4	0	5	0	6
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C9	0	2	0	2
Cytochrome P450 2C19	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	4
Protease	0	7	5	13
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 4	0	6	0	7
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 Protease	0	0	1	1
Chain B, HIV-1 Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
EWS/FLI fusion protein	6	0	0	6
G	6	0	0	6
cytochrome P450 2D6	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Gag-Pol polyprotein	0	3	0	3
ATP-dependent translocase ABCB1	0	3	0	3
Replicase polyprotein 1ab	0	3	2	5
Replicase polyprotein 1ab	0	5	2	7
Gag-Pol polyprotein	0	2	1	3
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	3	0	3
Alpha-1A adrenergic receptor	0	3	0	3
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	1	0	1
Protease	0	5	2	11
Inositol hexakisphosphate kinase 1	6	0	0	6
Gag-Pol polyprotein	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
Luciferase	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
progesterone receptor	8	0	0	8
estrogen-related nuclear receptor alpha	10	0	0	10
peroxisome proliferator activated receptor gamma	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
Histone H2A.x	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	2	0	0	2
thioredoxin reductase	2	0	0	2
phosphopantetheinyl transferase	3	0	0	3
GLS protein	2	0	0	2
AR protein	11	0	0	11
regulator of G-protein signaling 4	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	2	2
Carbonic anhydrase 1	0	1	0	2
Carbonic anhydrase 2	0	1	0	2
Integrin beta-3	1	0	1	2
Integrin alpha-IIb	1	0	1	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	3	2	1	6
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	2	2	4
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	2	4
Glutamate receptor ionotropic, NMDA 2B	0	2	2	4
Glutamate receptor ionotropic, NMDA 2C	0	2	2	4
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	2	4
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	2	4
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	2	4
Chain A, Hypoxanthine Phosphoribosyltransferase	0	1	0	1
Chain A, HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE	0	1	0	1
Chain A, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE	0	0	1	1
Chain B, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE	0	0	1	1
Chain A, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE	0	0	1	1
Chain A, Xanthine phosphoribosyltransferase	0	0	1	1
Purine nucleoside phosphorylase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Histidine triad nucleotide-binding protein 1	0	0	1	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	0	2	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Spike glycoprotein	1	0	2	3
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, PROTEASE RETROPEPSIN	0	1	0	1
Chain B, PROTEASE RETROPEPSIN	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
RAR-related orphan receptor gamma	5	0	0	5
SMAD family member 2	6	0	0	6
Fumarate hydratase	3	0	0	3
USP1 protein, partial	4	0	0	4
SMAD family member 3	6	0	0	6
Smad3	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
glucocorticoid receptor [Homo sapiens]	8	0	0	8
retinoid X nuclear receptor alpha	8	0	0	8
farnesoid X nuclear receptor	6	0	0	6
polyprotein	3	0	0	3
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
nuclear receptor ROR-gamma isoform 1	7	0	0	7
ATP-binding cassette sub-family C member 3	0	5	0	5
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Albumin	0	0	0	4
Gag-Pol polyprotein	0	2	0	2
Cellular tumor antigen p53	8	0	0	8
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
CAAX prenyl protease 1 homolog	0	1	0	1
Plasmepsin V	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	5	0	5
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
heat shock protein beta-1	4	0	0	4
Polyphenol oxidase 2	0	2	0	3
Bile salt export pump	0	1	0	3
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
PPM1D protein	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
IDH1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent phosphofructokinase	1	0	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	0	1	5
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	4	0	1	5
Gamma-aminobutyric acid receptor subunit delta	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	1	5
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	4	0	1	5
Gamma-aminobutyric acid receptor subunit beta-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit beta-2	4	0	1	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
GABA theta subunit	4	0	1	5
Gamma-aminobutyric acid receptor subunit epsilon	4	0	1	5
aryl hydrocarbon receptor	4	0	0	4
histone deacetylase 9 isoform 3	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
interleukin 8	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
activating transcription factor 6	2	0	0	2
Caspase-7	2	0	0	2
cellular tumor antigen p53 isoform a	1	0	0	1
caspase-3	2	0	0	2
lethal factor (plasmid)	1	0	0	1
Amyloid-beta precursor protein	0	2	0	2
Alpha-synuclein	0	2	0	2
Nuclear receptor ROR-gamma	2	0	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Chain A, Cruzipain	3	0	0	3
Microtubule-associated protein tau	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, Ferritin light chain	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
alpha-galactosidase	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 3	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Substance-K receptor	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Vasopressin V1a receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Thromboxane-A synthase	0	0	0	1
Sodium/bile acid cotransporter	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Sodium/bile acid cotransporter	0	0	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	2
Ileal sodium/bile acid cotransporter	0	2	0	2
G-protein coupled bile acid receptor 1	0	0	2	2
Bile acid receptor	0	0	1	1
Bile salt export pump	0	0	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Carbonic anhydrase 6	0	1	0	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
glucocerebrosidase	1	0	0	1
chromobox protein homolog 1	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Transthyretin	0	0	0	1
Androgen receptor	0	1	0	1
Thyroid hormone receptor alpha	0	2	2	4
Thyroid hormone receptor beta	0	2	2	4
Proliferating cell nuclear antigen	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Adenosine receptor A1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 8	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 1	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Histone deacetylase 6	0	1	1	2
Phospholipase A2	0	0	1	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research

Studies (59)

Protein Targets (533)

Leber Congenital Amaurosis

Synonyms(1)

Research

Studies (59)

Drugs Studied (42)

Protein Targets (533)