Page last updated: 2024-09-28

Heerfordt Syndrome

A manifestation of sarcoidosis marked by chronic inflammation of the parotid gland and the uvea.

Synonyms(3)

Synonym
Uveoparotitis
Heerfordt Syndrome
Uveoparotid Fever

Research Excerpts

Overview

ExcerptReference
"The Heerfordt syndrome is characterized by fever, uveitis, swelling of parotid gland and facial nerve palsy, and 53 cases have been reported in Japan until 2000."( Horie, T; Takahashi, N, 2002)

Research

Studies (20)

TimeframeStudies, This Condition (%)All Conditions %
pre-19903 (15.00)23.3326
1990's1 (5.00)12.5806
2000's9 (45.00)18.1394
2010's7 (35.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cytosine0low10
chloroquine0low10
indomethacin0low10
oxyphenbutazone0low10
prednisolone0low80
prednisone0low30
betamethasone0low10
technetium0low10
trolamine salicylate0low10
gallium citrate0low20
cidofovir anhydrous0low10
methotrexate0low10
organophosphonates0low10
cortisone0low20
gallium0low20

Protein Targets (363)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
pregnane X receptor3003
GLI family zinc finger 36006
AR protein7007
progesterone receptor7007
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]5005
estrogen-related nuclear receptor alpha6006
farnesoid X nuclear receptor4004
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha8008
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
IDH14004
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
nuclear receptor subfamily 1, group I, member 22002
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 25005
galanin receptor type 30101
nuclear factor erythroid 2-related factor 2 isoform 16006
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40607
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump0707
Glucocorticoid receptor08215
Glycine receptor subunit alpha-10808
Glutamate receptor 24004
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Canalicular multispecific organic anion transporter 10606
ORF730011
thioredoxin reductase4004
PPM1D protein1001
TDP1 protein7007
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0202
euchromatic histone-lysine N-methyltransferase 25005
Spike glycoprotein0112
Replicase polyprotein 1ab0112
glucose-6-phosphate 1-dehydrogenase isoform b0202
flap endonuclease 13003
Transmembrane protease serine 20112
Dihydrofolate reductase 0202
DNA ligase0101
Interferon beta4004
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein0101
Histidine-rich protein PFHRP-II0102
Procathepsin L0213
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
Cytochrome P450 3A40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0101
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Spike glycoprotein0101
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
DNA ligase 10101
Muscarinic acetylcholine receptor M30101
Serine/threonine-protein kinase mTOR0101
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Spike glycoprotein3115
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20303
Sigma intracellular receptor 20101
Phosphoethanolamine N-methyltransferase0101
Ataxin-23003
Sigma non-opioid intracellular receptor 10101
Angiotensin-converting enzyme 2 0112
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
Thymidine kinase 0101
Solute carrier family 22 member 60203
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Thymidine kinase0001
Solute carrier family 22 member 60204
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
endonuclease IV1001
dopamine D1 receptor2002
RAR-related orphan receptor gamma6006
GLS protein1001
aldehyde dehydrogenase 1 family, member A14004
regulator of G-protein signaling 41001
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha5005
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)4004
peripheral myelin protein 22 isoform 12002
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 13003
heat shock protein beta-13003
geminin4004
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 12002
M-phase phosphoprotein 83003
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi2002
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 433003
GABA theta subunit2002
Multidrug and toxin extrusion protein 10202
Gamma-aminobutyric acid receptor subunit epsilon2002
Deoxycytidine kinase0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, Cruzipain1001
Luciferase2002
interleukin 81001
hypoxia-inducible factor 1 alpha subunit2002
SMAD family member 22002
SMAD family member 32002
Microtubule-associated protein tau3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
estrogen receptor 2 (ER beta)4004
EWS/FLI fusion protein2002
G2002
67.9K protein2002
glucocerebrosidase1001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C9 precursor1001
vitamin D3 receptor isoform VDRA4004
thyroid hormone receptor beta isoform 24004
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 11001
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 13003
DNA polymerase kappa isoform 12002
lamin isoform A-delta102002
neuropeptide S receptor isoform A1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
HLA class I histocompatibility antigen, B alpha chain 2002
Albumin0112
Cellular tumor antigen p535005
Prostaglandin G/H synthase 10203
ATP-dependent translocase ABCB10101
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0102
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20314
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
Histamine H2 receptor1001
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Nuclear receptor ROR-gamma2002
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G2002
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30102
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 80102
Inositol hexakisphosphate kinase 12002
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30203
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
cytochrome P450 2C9, partial2002
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, Ferritin light chain1001
acid sphingomyelinase1001
ClpP1001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase1001
ATAD5 protein, partial2002
USP1 protein, partial2002
nuclear receptor subfamily 1, group I, member 33003
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
Histone H2A.x1001
Bloom syndrome protein isoform 11001
cellular tumor antigen p53 isoform a2002
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
peripheral myelin protein 221001
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 11001
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20011
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
ATPase family AAA domain-containing protein 52002
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
ATP-dependent phosphofructokinase1001
Chain A, Beta-lactamase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Nrf21001
glp-1 receptor, partial1001
Fumarate hydratase1001
Microphthalmia-associated transcription factor0001
thioredoxin glutathione reductase2002
Smad31001
hypothetical protein, conserved1001
cytochrome P450 2D61001
polyprotein1001
caspase recruitment domain family, member 150101
Caspase-71001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-31001
histone deacetylase 9 isoform 31001
receptor-interacting serine/threonine-protein kinase 2 isoform 10101
serine/threonine-protein kinase PLK11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Beta lactamase (plasmid)0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Cytochrome P450 2C9 0101
Glutamine synthetase0011
Androgen receptor0101
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]