Page last updated: 2024-09-27

Anticholinergic Syndrome

Adverse drug effects associated with CHOLINERGIC ANTAGONISTS. Clinical features include TACHYCARDIA; HYPERTHERMIA; MYDRIASIS, dry skin and dry mucous membranes, decreased bowel sounds and urinary retention in peripheral anticholinergic syndrome; and HALLUCINATIONS; PSYCHOSES; SEIZURES; and COMA in central anticholinergic syndrome.

Synonyms(3)

Synonym
Peripheral Anticholinergic Syndrome
Central Anticholinergic Syndrome
Anticholinergic Syndrome

Research Excerpts

Treatment

ExcerptReference
"Anesthesia-related central anticholinergic syndrome (CAS) is most commonly associated with administration of atropine or scopolamine, whereas glycopyrrolate is an extremely rare cause of CAS."( Plovsing, RR; Toksvang, LN, 2016)

Research

Studies (22)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's18 (81.82)28.8240
2020's4 (18.18)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carbamates0low10
tacrine0low10
biperiden0low10
cetirizine0low10
chlorpheniramine0low10
diphenhydramine0low10
donepezil0low10
oxybutynin0low20
propofol0low10
risperidone0low10
physostigmine0low50
diphenhydramine hydrochloride0low10
glycopyrrolate0low10
dexchlorpheniramine0low10
sertraline0low10
rivastigmine0low10
hyoscyamine0low10
atropine0low60
codeine0low10
butylscopolammonium bromide0low10
scopolamine hydrobromide0low40
piperidines0low10
olanzapine0low10

Protein Targets (405)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, 2-oxoglutarate Oxygenase4004
GLI family zinc finger 37007
AR protein7007
nuclear receptor subfamily 1, group I, member 35005
glucocorticoid receptor [Homo sapiens]4004
retinoid X nuclear receptor alpha2002
pregnane X nuclear receptor5005
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta1001
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0303
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
5-hydroxytryptamine receptor 4014014
Bile salt export pump012012
Muscarinic acetylcholine receptor M2018224
Muscarinic acetylcholine receptor M4017120
Muscarinic acetylcholine receptor M107110
Muscarinic acetylcholine receptor M30619
Muscarinic acetylcholine receptor M40518
Muscarinic acetylcholine receptor M50518
Muscarinic acetylcholine receptor M5016119
Muscarinic acetylcholine receptor M208213
Muscarinic acetylcholine receptor M1018224
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M3017120
Alpha-1D adrenergic receptor0808
5-hydroxytryptamine receptor 2C014014
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor1004
5-hydroxytryptamine receptor 70101
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0123
Canalicular multispecific organic anion transporter 10707
Luciferase2002
thioredoxin reductase5005
PPM1D protein2002
arylsulfatase A5005
euchromatic histone-lysine N-methyltransferase 2100010
flap endonuclease 13003
Interferon beta4004
Ataxin-25005
Chain A, Beta-lactamase3003
USP1 protein, partial4004
cytochrome P450 2D67007
IDH13003
chromobox protein homolog 13003
geminin7007
lamin isoform A-delta106006
atrial natriuretic peptide receptor 2 precursor4004
Histamine H1 receptor011112
Angiopoietin-1 receptor0011
Potassium voltage-gated channel subfamily H member 2013013
Multidrug and toxin extrusion protein 10303
Histamine H4 receptor0202
ATP-dependent phosphofructokinase3003
atrial natriuretic peptide receptor 1 precursor2002
MBT domain-containing protein 10202
Solute carrier family 22 member 10202
Lethal(3)malignant brain tumor-like protein 40202
Lethal(3)malignant brain tumor-like protein 30202
Chloroquine resistance transporter0101
Solute carrier family 22 member 20202
Lethal(3)malignant brain tumor-like protein 10202
retinoic acid nuclear receptor alpha variant 13003
nuclear factor erythroid 2-related factor 2 isoform 14004
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D60505
Cytochrome P450 2D30101
UDP-glucuronosyltransferase 2B70001
Delta-type opioid receptor0303
Kappa-type opioid receptor0101
Mu-type opioid receptor0213
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Cytochrome P450 2D40101
Mas-related G-protein coupled receptor member X20011
GLS protein7007
DNA polymerase kappa isoform 11001
Aldo-keto reductase family 1 member B1012012
Alpha-2A adrenergic receptor0808
Alpha-2B adrenergic receptor0808
Sodium-dependent noradrenaline transporter 013114
Histamine H2 receptor0404
5-hydroxytryptamine receptor 2A010010
Histamine H1 receptor0204
Sodium-dependent serotonin transporter09110
Sodium-dependent dopamine transporter 0617
Sigma non-opioid intracellular receptor 10707
Histamine H3 receptor0002
phosphopantetheinyl transferase2002
Thrombopoietin1001
thyroid stimulating hormone receptor4004
regulator of G-protein signaling 43003
EWS/FLI fusion protein3003
estrogen nuclear receptor alpha7007
v-jun sarcoma virus 17 oncogene homolog (avian)4004
cytochrome P450 2D6 isoform 13003
vitamin D3 receptor isoform VDRA4004
potassium voltage-gated channel subfamily H member 2 isoform d3003
thyroid hormone receptor beta isoform 25005
huntingtin isoform 21001
muscarinic acetylcholine receptor M14004
Cellular tumor antigen p536006
Cytochrome P450 2C9 0202
Angiotensin-converting enzyme0707
5-hydroxytryptamine receptor 2B012012
Histamine N-methyltransferase0002
Cytochrome P450 2J20202
Sodium channel protein type 5 subunit alpha0202
Nuclear receptor subfamily 3 group C member 3 0707
Calcium release-activated calcium channel protein 10101
Protein orai-20101
Protein orai-30101
endonuclease IV1001
TDP1 protein6006
estrogen-related nuclear receptor alpha4004
peroxisome proliferator-activated receptor delta2002
thyroid stimulating hormone receptor2002
peripheral myelin protein 22 isoform 12002
thyroid hormone receptor beta isoform a1001
mitogen-activated protein kinase 12002
eyes absent homolog 2 isoform a1001
DNA polymerase iota isoform a (long)3003
survival motor neuron protein isoform d3003
Alpha-synuclein1001
Inositol monophosphatase 12002
TAR DNA-binding protein 431001
peripheral myelin protein 225005
Acetylcholinesterase0719
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Bile salt export pump0303
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Acetylcholinesterase0505
Amyloid-beta precursor protein0303
Cholinesterase0707
ATP-dependent translocase ABCB10204
Cytochrome P450 3A40606
5-hydroxytryptamine receptor 1A0404
Amine oxidase [flavin-containing] B0303
Amine oxidase [flavin-containing] A 0303
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] A 0202
Acetylcholinesterase0617
Acetylcholinesterase0629
Liver carboxylesterase 10303
Acetylcholinesterase 0606
Amine oxidase [flavin-containing] B0101
Choline O-acetyltransferase 0202
Acetylcholinesterase0505
Glycogen synthase kinase-3 beta0202
Beta-secretase 10202
Cholinesterase0719
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Cholinesterase0404
Acetylcholine receptor subunit epsilon0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Cytochrome P450 1B10101
Sigma non-opioid intracellular receptor 10202
Acyl-CoA:cholesterol acyltransferase 0303
Carboxylic ester hydrolase 0405
Carboxylic ester hydrolase 0606
Histamine H3 receptor0202
Chain A, Phospholipase A20011
Chain A, Phospholipase A2 VRV-PL-VIIIa0011
ATAD5 protein, partial3003
importin subunit beta-1 isoform 11001
serine/threonine-protein kinase PLK11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
5-hydroxytryptamine receptor 3E0101
aryl hydrocarbon receptor3003
lysosomal alpha-glucosidase preproprotein1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
FAD-linked sulfhydryl oxidase ALR0001
5-hydroxytryptamine receptor 3B0101
5-hydroxytryptamine receptor 1A0235
5-hydroxytryptamine receptor 2C0404
Glucose-6-phosphate 1-dehydrogenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150202
D(2) dopamine receptor0404
5-hydroxytryptamine receptor 2A0505
Alpha-1B adrenergic receptor0303
Alpha-2C adrenergic receptor0606
D0303
D(3) dopamine receptor0303
Alpha-2B adrenergic receptor0202
D(1A) dopamine receptor0404
D(4) dopamine receptor0303
Alpha-2C adrenergic receptor0202
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0202
Alpha-1D adrenergic receptor0303
Adenosine receptor A10101
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 70202
Alpha-1A adrenergic receptor0303
Alpha-1B adrenergic receptor0202
D(3) dopamine receptor0606
Alpha-1A adrenergic receptor0303
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60303
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
Spike glycoprotein3003
D(2) dopamine receptor0505
Disintegrin and metalloproteinase domain-containing protein 171001
Transporter0202
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
Transporter0404
Fumarate hydratase2002
cytochrome P450 family 3 subfamily A polypeptide 42002
G2002
polyprotein2002
D(1A) dopamine receptor3003
HLA class I histocompatibility antigen, B alpha chain 2002
Cytochrome P450 2C190303
Mu-type opioid receptor0101
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
acetylcholinesterase3003
RAR-related orphan receptor gamma1001
aldehyde dehydrogenase 1 family, member A12002
nonstructural protein 12002
Bloom syndrome protein isoform 12002
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
M-phase phosphoprotein 81001
histone acetyltransferase KAT2A isoform 11001
Acetylcholinesterase0101
Chain A, Ferritin light chain1001
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
progesterone receptor1001
farnesoid X nuclear receptor2002
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
activating transcription factor 62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Histone H2A.x1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
heat shock protein beta-11001
cytochrome P450 3A4 isoform 12002
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit pi2114
UDP-glucuronosyltransferase 1A90001
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-12114
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit delta2114
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-22114
Gamma-aminobutyric acid receptor subunit alpha-52114
Gamma-aminobutyric acid receptor subunit alpha-32114
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Prostaglandin G/H synthase 10101
Gamma-aminobutyric acid receptor subunit gamma-12114
Gamma-aminobutyric acid receptor subunit alpha-22114
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-42114
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit gamma-32114
Gamma-aminobutyric acid receptor subunit alpha-62114
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit alpha-12114
Gamma-aminobutyric acid receptor subunit beta-32114
Gamma-aminobutyric acid receptor subunit beta-22114
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
GABA theta subunit2114
Gamma-aminobutyric acid receptor subunit epsilon2114
UDP-glucuronosyltransferase 1A80001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Smad32002
cytochrome P450 2C19 precursor2002
transcriptional regulator ERG isoform 31001
Solute carrier family 22 member 20202
Voltage-dependent calcium channel gamma-2 subunit2002
Albumin0011
Beta-1 adrenergic receptor0101
Glutamate receptor 22002
Glycine receptor subunit alpha-10011
Sodium-dependent dopamine transporter0303
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 1A0101
Multidrug and toxin extrusion protein 20202
Acyl-CoA desaturase 10202
Acetylcholine receptor subunit epsilon0101
Sodium-dependent serotonin transporter0303
Cholinesterase0101
Tyrosine-protein kinase SYK0101
glp-1 receptor, partial1001
67.9K protein1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
NPC intracellular cholesterol transporter 1 precursor1001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Rap guanine nucleotide exchange factor 31001
Transcriptional activator protein LuxR0101
D(1B) dopamine receptor0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Melanocortin receptor 50202
D(1A) dopamine receptor1001
Envelope glycoprotein0011
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10101
Chain A, ACETYLCHOLINESTERASE0101
Chain A, liver Carboxylesterase I0101
Chain A, Histamine N-methyltransferase0101
Chain A, Histamine N-methyltransferase0101
Chain A, Histamine N-methyltransferase0101
Chain A, Histamine N-methyltransferase0101
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
15-lipoxygenase, partial1001
SMAD family member 21001
NFKB1 protein, partial1001
SMAD family member 31001
Glycogen synthase kinase-3 beta 0101
[Tau protein] kinase 0101
mu-type opioid receptor isoform MOR-10011
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
nuclear receptor ROR-gamma isoform 11001
lethal factor (plasmid)1001
5-hydroxytryptamine receptor 2A0011
Voltage-dependent L-type calcium channel subunit beta-40101
Voltage-dependent P/Q-type calcium channel subunit alpha-1A0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent T-type calcium channel subunit alpha-1G0101
Voltage-dependent calcium channel gamma-3 subunit0101
Voltage-dependent T-type calcium channel subunit alpha-1H0101
Coagulation factor XII0101
Neuronal acetylcholine receptor subunit alpha-30101
Cytochrome P450 1A20202
Cytochrome P450 2E10101
Muscarinic acetylcholine receptor M20011
Fatty acid-binding protein, liver0011
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-40101
Cannabinoid receptor 10101
Trypanothione reductase0101
Cannabinoid receptor 2 0101
Neuronal acetylcholine receptor subunit alpha-60101
Gastrotropin0011
Voltage-dependent L-type calcium channel subunit beta-30101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent calcium channel gamma-7 subunit0101
Small conductance calcium-activated potassium channel protein 30101
Cyclin-dependent-like kinase 5 0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Histamine N-methyltransferase 0101
Voltage-dependent L-type calcium channel subunit beta-10101
Glutamate receptor ionotropic, NMDA 10101
Voltage-dependent calcium channel gamma-1 subunit0101
Voltage-dependent L-type calcium channel subunit beta-20101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Cyclin-dependent kinase 5 activator 10101
Voltage-dependent R-type calcium channel subunit alpha-1E0101
Voltage-dependent calcium channel subunit alpha-2/delta-40101
Voltage-dependent calcium channel subunit alpha-2/delta-30101
Voltage-dependent calcium channel gamma-8 subunit0101
Voltage-dependent calcium channel gamma-6 subunit0101
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Voltage-dependent calcium channel gamma-4 subunit0101
Voltage-dependent calcium channel gamma-5 subunit0101
Voltage-dependent calcium channel gamma-2 subunit0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]