fr-167653 and Weight-Loss

fr-167653 has been researched along with Weight-Loss* in 2 studies

Other Studies

2 other study(ies) available for fr-167653 and Weight-Loss

Article	Year
Proinflammatory cytokine inhibitor prolongs the survival of rats with heart failure induced by pressure overload. Japanese circulation journal, 2001, Volume: 65, Issue:6 Although an increased expression of proinflammatory cytokines has been reported in cardiac tissue samples from patients with congestive heart failure (CHF) and in various animal models of CHF, the role of these cytokines in the disease remains to be determined. Dahl salt-sensitive (DS) rats fed a high salt diet develop hypertension, cardiac hypertrophy and eventually CHF. In the present study, DS rats were treated with FR167653 (1-[7-(4-fluorophenyl)-1,2,3,4-tetrahydro-8-(4-pyridyl)pyrazolo[5,1-c][1,2,4]triazin-2-yl]-2-phenylethanedione sulfate monohydrate), a new low molecular weight inflammatory cytokine inhibitor. Treatment with 10 mg/kg per day of FR167653 significantly prolonged the survival of the animals and also prevented the bodyweight loss associated with heart failure. In conclusion, a non-peptide proinflammatory cytokine inhibitor improved the survival of animals with heart failure. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiomegaly; Disease Models, Animal; Hypertension; Male; Pyrazoles; Pyridines; Rats; Rats, Inbred Strains; Survival Rate; Weight Loss	2001
Lack of effect of the cytokine suppressive agent FR167653 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma. Cancer letters, 2000, Aug-31, Volume: 157, Issue:1 Daily s.c. administration of 6 mg/kg of FR167653 (an inhibitor of the synthesis of interleukin-1 and tumour necrosis factor-alpha) to rats bearing the ascites hepatoma Yoshida AH-130 (a highly cachectic tumour) did not prevent either the anorexia or the massive weight loss - affecting both adipose tissue and skeletal muscle - present in the cachectic animals. The compound did not affect the circulating levels of triacylglycerols or other metabolites such as glucose or lactate. Nor did the administration of FR167653 influence tumour growth. It is concluded that the drug is unable to reverse the cachectic state in this particular experimental tumour model. Topics: Adipose Tissue; Alanine; Animals; Anorexia; Blood Glucose; Cachexia; Cell Division; Female; Interleukin-1; Lactic Acid; Liver Neoplasms, Experimental; Muscle, Skeletal; Organ Size; Protein Synthesis Inhibitors; Pyrazoles; Pyridines; Rats; Rats, Wistar; Sarcoma, Yoshida; Triglycerides; Tumor Necrosis Factor-alpha; Weight Loss	2000

Article

Year

Proinflammatory cytokine inhibitor prolongs the survival of rats with heart failure induced by pressure overload.

Japanese circulation journal, 2001, Volume: 65, Issue:6

Although an increased expression of proinflammatory cytokines has been reported in cardiac tissue samples from patients with congestive heart failure (CHF) and in various animal models of CHF, the role of these cytokines in the disease remains to be determined. Dahl salt-sensitive (DS) rats fed a high salt diet develop hypertension, cardiac hypertrophy and eventually CHF. In the present study, DS rats were treated with FR167653 (1-[7-(4-fluorophenyl)-1,2,3,4-tetrahydro-8-(4-pyridyl)pyrazolo[5,1-c][1,2,4]triazin-2-yl]-2-phenylethanedione sulfate monohydrate), a new low molecular weight inflammatory cytokine inhibitor. Treatment with 10 mg/kg per day of FR167653 significantly prolonged the survival of the animals and also prevented the bodyweight loss associated with heart failure. In conclusion, a non-peptide proinflammatory cytokine inhibitor improved the survival of animals with heart failure.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiomegaly; Disease Models, Animal; Hypertension; Male; Pyrazoles; Pyridines; Rats; Rats, Inbred Strains; Survival Rate; Weight Loss

2001

Lack of effect of the cytokine suppressive agent FR167653 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma.

Cancer letters, 2000, Aug-31, Volume: 157, Issue:1

Daily s.c. administration of 6 mg/kg of FR167653 (an inhibitor of the synthesis of interleukin-1 and tumour necrosis factor-alpha) to rats bearing the ascites hepatoma Yoshida AH-130 (a highly cachectic tumour) did not prevent either the anorexia or the massive weight loss - affecting both adipose tissue and skeletal muscle - present in the cachectic animals. The compound did not affect the circulating levels of triacylglycerols or other metabolites such as glucose or lactate. Nor did the administration of FR167653 influence tumour growth. It is concluded that the drug is unable to reverse the cachectic state in this particular experimental tumour model.

Topics: Adipose Tissue; Alanine; Animals; Anorexia; Blood Glucose; Cachexia; Cell Division; Female; Interleukin-1; Lactic Acid; Liver Neoplasms, Experimental; Muscle, Skeletal; Organ Size; Protein Synthesis Inhibitors; Pyrazoles; Pyridines; Rats; Rats, Wistar; Sarcoma, Yoshida; Triglycerides; Tumor Necrosis Factor-alpha; Weight Loss

2000