Compounds > coumarin 480
Page last updated: 2024-11-06

coumarin 480

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Coumarin 480 is a fluorescent dye that exhibits bright blue fluorescence upon excitation with ultraviolet light. It is widely used in various applications, including fluorescence microscopy, flow cytometry, and bioimaging. Coumarin 480 is synthesized through a multi-step process involving the condensation of 7-hydroxycoumarin with a suitable aromatic aldehyde. The dye exhibits high quantum yield and photostability, making it suitable for long-term fluorescence imaging. It is particularly useful for studying cellular processes, protein dynamics, and molecular interactions. Coumarin 480 has been used to label various biological targets, including proteins, nucleic acids, and lipids. Its ability to penetrate cell membranes allows for the visualization of intracellular structures and dynamics. Coumarin 480 is also used as a probe for detecting specific ions, such as calcium, and for monitoring enzymatic reactions. The compound's high fluorescence intensity and relatively long fluorescence lifetime make it a valuable tool for a wide range of biological and chemical research.'

coumarin 480: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID94517
CHEBI ID51774
SCHEMBL ID394375
MeSH IDM0575524

Synonyms (44)

Synonym
AKOS002345301
1h,5h,11h-[1]benzopyrano[6,7,8-ij]quinolizin-11-one, 2,3,6,7-tetrahydro-9-methyl-
2,3,6,7-tetrahydro-9-methyl-1h,5h,11h-(1)benzopyrano(6,7,8-ij)quinolizin-11-one
ccris 4960
brn 1220752
1h,5h,11h-(1)benzopyrano(6,7,8-ij)quinolizin-11-one, 2,3,6,7-tetrahydro-9-methyl-
einecs 255-285-6
c 102
nsc 290431
coumarin 480
2,3,5,6-1h,4h-tetrahydro-8-methylquinolazino-(9,9a,1-gh)coumarin
nsc290431
41267-76-9
nsc-290431
exciton 480
coumarin 102
1h,11h-[1]benzopyrano[6,7,8-ij]quinolizin-11-one, 2,3,6,7-tetrahydro-9-methyl-
coumarin 102, dye content 99 %
OPREA1_258576
STK325582
9-methyl-2,3,6,7-tetrahydro-1h,5h,11h-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one
CHEBI:51774
2,3,6,7-tetrahydro-9-methyl-1h,5h,11h-[1]benzopyrano[6,7,8-ij]quinolizin-11-one
C2267
BBL010577
0m1gi783qt ,
unii-0m1gi783qt
DTXSID9068293
mfcd00041844
SCHEMBL394375
coumarin102
k-102
CCG-251258
2,3,6,7-tetrahydro-9-methyl-1h,5h-quinolizino(9,1-gh)coumarin
coumarin-102
9-methyl-2,3,6,7-tetrahydro-1h-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5h)-one
FT-0701397
6-methyl-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2(7),5,8-tetraen-4-one
Q27122741
8-methyl-2,3,5,6-tetrahydro-1h,4h-11-oxa-3a-aza-benzo(de)anthracen-10-one
T70892
CS-0313534
9-ethyl-2,3,6,7-tetrahydro-1h-pyrano[2,3-f]pyrido[3,2,1-ij]
quinolin-11(5h)-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
fluorochromeA fluorescent dye used to stain biological specimens.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
7-aminocoumarinsAny member of the class of coumarins that contains a 7-amino-2H-chromen-2-one skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (90.91)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.32

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.32 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.32)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		2.1110sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
hydroxide ion
[no description available]		2.110oxygen hydridemouse metabolite
uvitex swn
Uvitex SWN: optical brightner from Ciba; structure		2.17107-aminocoumarinsfluorochrome
isopropyl myristate
isopropyl myristate: used for microemulsions; structure		2.0810fatty acid ester
rhodamine 6g
rhodamine 6G: RN given refers to HCl		2.0810
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		7.0710copper group element atom;
elemental silver		Escherichia coli metabolite
galactose
aldohexose : A hexose with a (potential) aldehyde group at one end.		2.0810
poloxalene
Poloxalene: A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.. pluronic : A triblock copolymer composed of a central hydrophobic chain of poly(propylene oxide) flanked by two hydrophilic chains of poly(ethylene oxide).		2.0710epoxide
coumarin 153
coumarin 153: structure in first source		2.81307-aminocoumarinsfluorochrome
n-hexadecyl-n,n-dimethyl-3-ammonio-1-propanesulfonate
[no description available]		2.1110
coumarin 343
coumarin 343: structure in first source		2.07107-aminocoumarinsfluorochrome
1-methyl-3-ethylimidazolium
1-methyl-3-ethylimidazolium: structure given in first source. 1-ethyl-3-methylimidazolium : A 1-alkyl-3-methylimidazolium in which the alkyl substituent at C-1 is ethyl.		2.08101-alkyl-3-methylimidazolium
4-(dicyanomethylene)-2-methyl-6-(4-(dimethylamino)styryl)-4h-pyran
2-(2-(4-(dimethylamino)styryl)-6-methyl-4H-pyran-4-ylidene)malononitrile: structure in first source		2.0710
1-butyl-3-methylimidazolium tetrafluoroborate
[no description available]		2.0810
sodium borohydride
sodium borohydride: RN given refers to parent cpd		2.0710inorganic sodium salt;
metal tetrahydridoborate
thiosuccinic acid
thiosuccinic acid: inhibits fibrinolysin		2.0810
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		3.7190benzenes;
hydroxycoumarin;
methyl ketone
sorbitan monolaurate
sorbitan monolaurate: span type materials are artificial esters of the common fatty acids & hexitol anhydrides derived from sorbitol		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110