stellettin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

stellettin B: from the marine sponge Rhabdastrella globostellata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	5352082
CHEMBL ID	402204
MeSH ID	M0421016

Synonyms (6)

Synonym
nsc-692274
stellettin b
NSC692274 ,
stelletin b
CHEMBL402204
(3z,3as,5ar,9ar,9bs)-3a,6,6,9a-tetramethyl-3-[(3e,5e)-6-(5-methyl-6-oxopyran-2-yl)hepta-3,5-dien-2-ylidene]-4,5,5a,8,9,9b-hexahydro-1h-cyclopenta[a]naphthalene-2,7-dione

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay ID	Title	Year	Journal	Article
AID333741	Cytotoxicity against human MDA-MB-423 cells after 48 hrs by MTT assay	2004	Journal of natural products, Dec, Volume: 67, Issue:12	Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID332274	Cytotoxicity against P21+ wild type human HCT116 cells after 48 hrs by MTS assay	2002	Journal of natural products, Feb, Volume: 65, Issue:2	Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.
AID332272	Cytotoxicity against P53+ wild type human HCT116 cells after 48 hrs by MTS assay	2002	Journal of natural products, Feb, Volume: 65, Issue:2	Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.
AID355203	Antagonist activity at mouse RXRalpha assessed as inhibition of 9-cis-retinoic acid-induced response by differential proteolytic sensitivity assay	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Cytotoxic triterpenes from a marine sponge, Stelletta sp.
AID333739	Cytotoxicity against human PC-3MIE8 cells after 48 hrs by MTT assay	2004	Journal of natural products, Dec, Volume: 67, Issue:12	Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID333740	Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay	2004	Journal of natural products, Dec, Volume: 67, Issue:12	Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID355201	Binding affinity to human RXRalpha assessed as induction of receptor conformational change at 1 uM	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Cytotoxic triterpenes from a marine sponge, Stelletta sp.
AID332271	Cytotoxicity against P53 deficient human HCT116 cells after 48 hrs by MTS assay	2002	Journal of natural products, Feb, Volume: 65, Issue:2	Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.
AID332273	Cytotoxicity against P21 deficient human HCT116 cells after 48 hrs by MTS assay	2002	Journal of natural products, Feb, Volume: 65, Issue:2	Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.
AID333738	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	2004	Journal of natural products, Dec, Volume: 67, Issue:12	Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID333742	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay	2004	Journal of natural products, Dec, Volume: 67, Issue:12	Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID361183	Cytotoxicity against human A2780 cells	2001	Journal of natural products, Jun, Volume: 64, Issue:6	Stelliferin riboside, a triterpene monosaccharide isolated from the Fijian sponge Geodia globostellifera.
AID333743	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	2004	Journal of natural products, Dec, Volume: 67, Issue:12	Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID361184	Cytotoxicity against human K562 cells	2001	Journal of natural products, Jun, Volume: 64, Issue:6	Stelliferin riboside, a triterpene monosaccharide isolated from the Fijian sponge Geodia globostellifera.
AID318601	Cytotoxicity against mouse P388 cells assessed as concentration required for 50% inhibition	2008	Journal of natural products, Mar, Volume: 71, Issue:3	Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).
AID355202	Binding affinity to mouse RXRalpha assessed as induction of receptor conformational change at 1 uM	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Cytotoxic triterpenes from a marine sponge, Stelletta sp.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (6.67)	18.2507
2000's	6 (40.00)	29.6817
2010's	4 (26.67)	24.3611
2020's	4 (26.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.48 (24.57)
Research Supply Index	2.77 (2.92)
Research Growth Index	5.25 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.48)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
oxidopamine Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.. oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).	2.21	1	benzenetriol; catecholamine; primary amino compound	drug metabolite; human metabolite; neurotoxin
temozolomide [no description available]	2.6	1	imidazotetrazine; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent; prodrug
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.02	1	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
toyocamycin Toyocamycin: 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.. toyocamycin : An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.	2.04	1	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; nitrile; ribonucleoside	antimetabolite; antineoplastic agent; apoptosis inducer; bacterial metabolite
ursolic acid [no description available]	2.04	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	geroprotector; plant metabolite
beta-peltatin beta-peltatin : An organic heterotetracyclic compound that is alpha-peltatin in which the phenolic hydroxy group of the 4-hydroxy-3,5-dimethoxyphenyl substitutent had been converted into the corresponding methyl ether.	2.04	1	furonaphthodioxole; gamma-lactone; lignan; organic heterotetracyclic compound; phenols	antineoplastic agent; plant metabolite
imatinib mesylate imatinib methanesulfonate : A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.	2.15	1	methanesulfonate salt	anticoronaviral agent; antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
anthricin anthricin: antitumor constituent from Anthriscus sylvestris (L.) Hoffm; structure in first source. deoxypodophyllotoxin : A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 3,4,5-trimethoxyphenyl group.	2.04	1	furonaphthodioxole; gamma-lactone; lignan; methoxybenzenes	antineoplastic agent; apoptosis inducer; plant metabolite
cephaelin cephaelin: do not confuse with cephalin of brain; after emetine this is the most important alkaloid of ipecac; protein synthesis inhibitor. cephaeline : A pyridoisoquinoline comprising emetam having a hydroxy group at the 6'-position and methoxy substituents at the 7'-, 10- and 11-positions.	2.04	1	pyridoisoquinoline
dactinomycin Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)	2.04	1	actinomycin	mutagen
genistein [no description available]	2.04	1	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
daidzein [no description available]	2.04	1	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; phytoestrogen; plant metabolite
brefeldin a [no description available]	2.04	1	macrolide antibiotic	Penicillium metabolite
stellettin a stellettin A: an isomalabaricane triterpenoid; isolated from the sponge Stelletta tenuis; structure given in first source	2.43	2
jasplakinolide jasplakinolide: cyclodepsipeptide isolated from marine sponge Jaspis; active against Candida; RN refers to 2S-(2R,4E,6S,8R*)-isomer; structure in first source. jaspamide : A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity. It is an actin polymerization and stabilization inducer.	2.04	1	cyclodepsipeptide; phenols	actin polymerisation inducer; animal metabolite; antifungal agent; antineoplastic agent; apoptosis inducer; marine metabolite; neuroprotective agent
neoechinulin a neoechinulin A: from the marine-derived fungus Aspergillus sp.; structure in first source	2.04	1
ribose ribopyranose : The pyranose form of ribose.	7.6	1	D-ribose; ribopyranose
geoditin a geoditin A: isolated from the sponge Geodia japonica collected from the South China Sea; structure in first source	2.71	3
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	2.13	1
dacarbazine (E)-dacarbazine : A dacarbazine in which the N=N double bond adopts a trans-configuration.	2.6	1	dacarbazine
hymenialdisine [no description available]	2.04	1
debromohymenialdisine [no description available]	2.04	1

Condition	Relationship Strength	Studies
Cancer of Colon [description not available]	2.01	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.01	1
Carcinoma, Epidermoid [description not available]	2.41	1
Cancer of Mouth [description not available]	2.41	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	2.41	1
Mouth Neoplasms Tumors or cancer of the MOUTH.	2.41	1
Benign Neoplasms, Brain [description not available]	3.43	5
Astrocytoma, Grade IV [description not available]	3.61	6
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	3.43	5
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	3.61	6
Bladder Cancer [description not available]	7.6	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.6	1
Granulocytic Leukemia, Chronic [description not available]	2.15	1
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.	2.15	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.21	1
Idiopathic Parkinson Disease [description not available]	2.21	1
Parkinson Disease A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)	2.21	1

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