anthricin and Carcinoma--Lewis-Lung

anthricin has been researched along with Carcinoma--Lewis-Lung* in 1 studies

Other Studies

1 other study(ies) available for anthricin and Carcinoma--Lewis-Lung

Article	Year
Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana. Planta medica, 2002, Volume: 68, Issue:3 The petroleum ether fraction of Pulsatilla koreana (Ranunculaceae) was found to have an inhibitory effect on the tube-like formation of human umbilical venous endothelial (HUVE) cells and strong cytotoxic activity against five tumor cell lines. The active component isolated from the fraction was deoxypodophyllotoxin (DPT). The cytotoxic activity against the tumor cells comprising the A549, SK-OV-3, SK-MEL-2, HCT15, and B16F10 cell lines, expressed as ED50, ranged from 6 to 18 ng/ml. 3 ng/ml of DPT, a concentration considerably below the cytotoxic concentration, completely inhibited the tube-like formation of HUVE cells. Furthermore, DPT exhibited an inhibition ratio of 60 % on BDF1 mice bearing Lewis lung carcinoma cells. The inhibitory effect on the tube-like formation was suggested to play an important role in antitumor activity. Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Endothelium, Vascular; Etoposide; Humans; Medicine, East Asian Traditional; Mice; Plant Extracts; Plant Roots; Podophyllotoxin; Ranunculaceae; Tumor Cells, Cultured; Umbilical Veins	2002

Article

Year

Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana.

Planta medica, 2002, Volume: 68, Issue:3

The petroleum ether fraction of Pulsatilla koreana (Ranunculaceae) was found to have an inhibitory effect on the tube-like formation of human umbilical venous endothelial (HUVE) cells and strong cytotoxic activity against five tumor cell lines. The active component isolated from the fraction was deoxypodophyllotoxin (DPT). The cytotoxic activity against the tumor cells comprising the A549, SK-OV-3, SK-MEL-2, HCT15, and B16F10 cell lines, expressed as ED50, ranged from 6 to 18 ng/ml. 3 ng/ml of DPT, a concentration considerably below the cytotoxic concentration, completely inhibited the tube-like formation of HUVE cells. Furthermore, DPT exhibited an inhibition ratio of 60 % on BDF1 mice bearing Lewis lung carcinoma cells. The inhibitory effect on the tube-like formation was suggested to play an important role in antitumor activity.

Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Endothelium, Vascular; Etoposide; Humans; Medicine, East Asian Traditional; Mice; Plant Extracts; Plant Roots; Podophyllotoxin; Ranunculaceae; Tumor Cells, Cultured; Umbilical Veins

2002