Compounds > retrojusticidin b
Page last updated: 2024-09-27

retrojusticidin b

Description

retrojusticidin B: isolated from Phyllanthus myrtifolius; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PhyllanthusgenusA plant genus of the family EUPHORBIACEAE. Bahupatra (MEDICINE, AYURVEDIC) is prepared from this.[MeSH]Phyllanthaceae[no description available]

Cross-References

ID SourceID
PubMed CID460888
CHEMBL ID292540
MeSH IDM0480366

Synonyms (10)

Synonym
4-(2h-benzo[3,4-d]1,3-dioxolan-5-yl)-6,7-dimethoxy-3-hydrobenzo[f]isobenzofuran-1-one
82001-16-9
4-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-3h-benzo[f]isobenzofuran-1-one
retrojusticidin b
bdbm50240576
4-benzo[1,3]dioxol-5-yl-6,7-dimethoxy-3h-naphtho[2,3-c]furan-1-one
4-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-3h-benzo[f][2]benzofuran-1-one
CHEMBL292540 ,
4-(2h-benzo(3,4-d)1,3-dioxolan-5-yl)-6,7-dimethoxy-3-hydrobenzo(f)isobenzofuran-1-one
DTXSID80231512

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC50 (µMol)5.50000.00011.076810.0000AID354839
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID354839Inhibition of HIV1 reverse transcriptase1996Journal of natural products, Nov, Volume: 59, Issue:11
Six lignans from Phyllanthus myrtifolius.
AID354840Inhibition of human DNA polymerase alpha1996Journal of natural products, Nov, Volume: 59, Issue:11
Six lignans from Phyllanthus myrtifolius.
AID404007Inhibition of human DNA polymerase alpha1998Journal of natural products, Nov, Volume: 61, Issue:11
Antiviral activity of lignans.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
podophyllotoxin[no description available]medium10furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
etoposide[no description available]medium10beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
arctigenin[no description available]medium10lignan
picropodophyllin[no description available]medium10furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antineoplastic agent;
insulin-like growth factor receptor 1 antagonist;
plant metabolite;
tyrosine kinase inhibitor
beta-peltatin[no description available]medium10furonaphthodioxole;
gamma-lactone;
lignan;
organic heterotetracyclic compound;
phenols		antineoplastic agent;
plant metabolite
alpha-peltatin[no description available]medium10furonaphthodioxole;
gamma-lactone;
lignan;
organic heterotetracyclic compound;
phenols		antineoplastic agent;
metabolite
diphyllin[no description available]medium10lignan
epipodophyllotoxin[no description available]medium10
4'-demethylpodophyllotoxin[no description available]medium10furonaphthodioxole;
organic heterotetracyclic compound;
phenols		metabolite
4'-demethylepipodophyllotoxin[no description available]medium10furonaphthodioxole;
organic heterotetracyclic compound;
phenols		antineoplastic agent
beta-peltatin a methyl ether[no description available]medium10lactone;
lignan
justicidin a[no description available]medium40lignan
rubschisandrin[no description available]medium10tannin
anthricin[no description available]medium10furonaphthodioxole;
gamma-lactone;
lignan;
methoxybenzenes		antineoplastic agent;
apoptosis inducer;
plant metabolite
schizandrin c[no description available]medium10tannin
trachelogenin[no description available]medium10lignan
gomisin j[no description available]medium10
gomisin-g[no description available]medium10
lignans[no description available]medium60
helioxanthin[no description available]medium10benzodioxoles;
furonaphthodioxole;
lignan		anti-HBV agent;
antineoplastic agent;
plant metabolite
taiwanin c[no description available]medium20benzodioxoles;
furonaphthodioxole;
lignan		antineoplastic agent;
plant metabolite;
platelet aggregation inhibitor
silver[no description available]medium10copper group element atom;
elemental silver		Escherichia coli metabolite
palladium[no description available]medium10metal allergen;
nickel group element atom;
platinum group metal atom
ConditionIndicatedRelationship StrengthStudiesTrials

Research Highlights

Pharmacokinetics (1)

ArticleYear
Pharmacokinetic and metabolic studies of retrojusticidin B, a potential anti-viral lignan, in rats.
Planta medica, Volume: 70, Issue: 12		2004
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]