anthricin has been researched along with Asthma* in 1 studies
1 other study(ies) available for anthricin and Asthma
| Article | Year |
|---|---|
Deoxypodophyllotoxin (DPT) inhibits eosinophil recruitment into the airway and Th2 cytokine expression in an OVA-induced lung inflammation.
The effect of deoxypodophyllotoxin (DPT) isolated from Anthriscus sylvestris Hoffm. was evaluated in an IN VIVO animal model for antiasthmatic activity. DPT (1.0 to 5 mg/kg) was given orally to ovalbumin (OVA)/alum-induced asthmatic mice. DPT reduced the number of infiltrated eosinophils in bronchoalveolar lavage (BAL) fluid in a dose-dependent manner. Dexamethasone (5 mg/kg), which was used as a positive control, also strongly inhibited the number of infiltrated eosinophils. The effect of DPT on a transcript profile in a murine asthma model was determined by RT-PCR, which showed that DPT decreased the mRNA levels of the Th2 cytokines. Northern blot analysis showed that DPT also reduced both the eotaxin and arginase I mRNA levels in a dose-dependent manner. Topics: Animals; Anti-Asthmatic Agents; Apiaceae; Arginase; Asthma; Cell Movement; Chemokine CCL11; Chemokines, CC; Cytokines; Drugs, Chinese Herbal; Eosinophils; Female; Gene Expression Regulation; Mice; Mice, Inbred BALB C; Ovalbumin; Plant Preparations; Pneumonia; Podophyllotoxin; Protein Isoforms; RNA, Messenger; Th2 Cells | 2006 |