xanthoangelol has been researched along with Leukemia* in 2 studies
2 other study(ies) available for xanthoangelol and Leukemia
| Article | Year |
|---|---|
3'-Geranyl-mono-substituted chalcone Xanthoangelovl induces apoptosis in human leukemia K562 cells via activation of mitochondrial pathway.
Topics: Apoptosis; Caspase 3; Cell Shape; Chalcone; Humans; K562 Cells; Leukemia; Membrane Potential, Mitochondrial; Mitochondria; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tumor Necrosis Factor-alpha | 2017 |
Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells.
Xanthoangelol, a major chalcone constituent of the stem exudates of Angelica keiskei, was evaluated for cell toxicity and apoptosis-inducing activity in human neuroblastoma (IMR-32) and leukemia (Jurkat) cells. Xanthoangelol concentration-dependently reduced the survival rates of both cell lines as revealed by the trypan blue exclusion test. Early apoptosis induced by 4 h incubation with xanthoangelol was detected using flow cytometry after double-staining with annexin V and propidium iodide (PI). Western blot analysis showed that xanthoangelol markedly reduced the level of precursor caspase-3 and increased the level of cleaved caspase-3, but Bax and Bcl-2 proteins were not affected. These results suggest that xanthoangelol induces apoptotic cell death by activatation of caspase-3 in neuroblastoma and leukemia cells through a mechanism that does not involve Bax/Bcl-2 signal transduction. Therefore, xanthoangelol may be applicable as an effective drug for treatment of neuroblastoma and leukemia. Topics: Angelica; Apoptosis; Caspase 3; Caspases; Chalcone; Enzyme Activation; Humans; Leukemia; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2005 |