Target type: molecularfunction
Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. [EC:3.1.6.1]
Arylsulfatase activity is a type of hydrolase activity that specifically cleaves sulfate groups from aryl sulfate esters. These esters are molecules that contain a sulfate group (SO4) attached to an aromatic ring. Arylsulfatases play crucial roles in various biological processes by hydrolyzing these sulfate esters, including the breakdown of complex carbohydrates, detoxification of harmful substances, and modulation of signaling pathways.
The catalytic mechanism of arylsulfatases involves a two-step process. First, the enzyme binds to the substrate, positioning the sulfate group for attack. Second, the enzyme utilizes a nucleophile, typically a cysteine or serine residue, to cleave the sulfate group from the aromatic ring. This cleavage reaction results in the formation of an alcohol and a free sulfate ion.
The precise molecular function of arylsulfatase activity can vary depending on the specific enzyme and its cellular location. For example, some arylsulfatases are involved in the degradation of chondroitin sulfate, a component of cartilage, while others are responsible for the detoxification of steroids and bile acids.
Overall, arylsulfatase activity is a vital enzymatic process that contributes to the proper functioning of numerous cellular and physiological pathways. It plays a crucial role in maintaining homeostasis, detoxification, and the breakdown of complex molecules.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Steryl-sulfatase | A steryl-sulfatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08842] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| acetazolamide | Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) | monocarboxylic acid amide; sulfonamide; thiadiazoles | anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor |
| letrozole | nitrile; triazoles | antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor | |
| pioglitazone | pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS. | aromatic ether; pyridines; thiazolidinediones | antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic |
| estrone | Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens. | 17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols | antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite |
| dehydroepiandrosterone sulfate | dehydroepiandrosterone sulfate : A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone. Dehydroepiandrosterone Sulfate: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. | 17-oxo steroid; steroid sulfate | EC 2.7.1.33 (pantothenate kinase) inhibitor; human metabolite; mouse metabolite |
| 17-methylestradiol | 17-methylestradiol: RN given refers to parent cpd(17beta)-isomer | 3-hydroxy steroid | |
| acetoxyestrone | puboestrene: from the bark of Holarrhena pubescens; structure in first source | ||
| estrone-3-o-sulfamate | estrone-3-O-sulfamate: a steroid sulfatase inhibitor | ||
| estrone sulfate | estrone sulfate: sulfoconjugated estrone; RN given refers to parent cpd | 17-oxo steroid; steroid sulfate | human metabolite; mouse metabolite |
| irosustat | irosustat: Antineoplastic Agents, Hormonal; a tricyclic sulfamate ester; structure in first source | ||
| vorozole | vorozole: structure given in first source; vorozole/R 83842 is ((+)/dextro-isomer), RN 129731-10-8; R 83839 ((-)/levo-isomer) | benzotriazoles | |
| estradiol-3-o-sulfamate | |||
| 2-methoxyestradiol-3,17-o,o-bis(sulfamate) | 2-methoxyestradiol-3,17-O,O-bis(sulfamate): an antiangiogenic microtubule disruptor; antineoplastic agent; structure in first source | ||
| 2-meoemate | |||
| 4-methylcoumarin 7-o-sulfamate | |||
| kw 2581 | KW 2581: structure in first source | ||
| 2-ethylestradiol sulfamate | 2-ethyloestradiol-bis-sulfamate: structure in first source |