Target type: molecularfunction
Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. [EC:3.1.6.2]
Steryl-sulfatase activity is a hydrolytic enzyme activity that specifically cleaves the sulfate group from sterol sulfates. Sterol sulfates are derivatives of sterols, which are lipids that play important roles in cell membranes and signaling pathways. Sterol sulfatase activity is important for the regulation of sterol homeostasis. In humans, the enzyme sulfohydrolase 1 (SULF1) exhibits steryl-sulfatase activity and is responsible for the desulfation of cholesterol sulfate, a major sulfated sterol in humans. The desulfation of cholesterol sulfate by SULF1 is a critical step in the biosynthesis of cholesterol, which is an essential component of cell membranes. Additionally, steryl-sulfatase activity can also be involved in the metabolism of other sterol sulfates, such as dehydroepiandrosterone sulfate (DHEA-S), which is a precursor of the steroid hormone dehydroepiandrosterone (DHEA). The desulfation of DHEA-S by steryl-sulfatase can contribute to the regulation of DHEA levels, which are involved in a variety of physiological processes, including neuroprotection, immune modulation, and anti-aging. Steryl-sulfatase activity is also important in the context of disease. For example, deficiencies in steryl-sulfatase activity can lead to a build-up of sterol sulfates, which can contribute to the development of certain diseases, such as X-linked ichthyosis. This condition is characterized by dry, scaly skin, and other skin abnormalities. In addition, dysregulation of steryl-sulfatase activity has been implicated in cancer, and is a potential therapeutic target.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Steryl-sulfatase | A steryl-sulfatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08842] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| acetazolamide | Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) | monocarboxylic acid amide; sulfonamide; thiadiazoles | anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor |
| letrozole | nitrile; triazoles | antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor | |
| pioglitazone | pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS. | aromatic ether; pyridines; thiazolidinediones | antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic |
| estrone | Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens. | 17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols | antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite |
| dehydroepiandrosterone sulfate | dehydroepiandrosterone sulfate : A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone. Dehydroepiandrosterone Sulfate: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. | 17-oxo steroid; steroid sulfate | EC 2.7.1.33 (pantothenate kinase) inhibitor; human metabolite; mouse metabolite |
| 17-methylestradiol | 17-methylestradiol: RN given refers to parent cpd(17beta)-isomer | 3-hydroxy steroid | |
| acetoxyestrone | puboestrene: from the bark of Holarrhena pubescens; structure in first source | ||
| estrone-3-o-sulfamate | estrone-3-O-sulfamate: a steroid sulfatase inhibitor | ||
| estrone sulfate | estrone sulfate: sulfoconjugated estrone; RN given refers to parent cpd | 17-oxo steroid; steroid sulfate | human metabolite; mouse metabolite |
| irosustat | irosustat: Antineoplastic Agents, Hormonal; a tricyclic sulfamate ester; structure in first source | ||
| vorozole | vorozole: structure given in first source; vorozole/R 83842 is ((+)/dextro-isomer), RN 129731-10-8; R 83839 ((-)/levo-isomer) | benzotriazoles | |
| estradiol-3-o-sulfamate | |||
| 2-methoxyestradiol-3,17-o,o-bis(sulfamate) | 2-methoxyestradiol-3,17-O,O-bis(sulfamate): an antiangiogenic microtubule disruptor; antineoplastic agent; structure in first source | ||
| 2-meoemate | |||
| 4-methylcoumarin 7-o-sulfamate | |||
| kw 2581 | KW 2581: structure in first source | ||
| 2-ethylestradiol sulfamate | 2-ethyloestradiol-bis-sulfamate: structure in first source |