| Assay ID | Title | Year | Journal | Article |
|---|
| AID112978 | Compound was tested for the effective dose (ED50) for each time point in Mice. 95% confidence limits are given in parentheses 1 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID112982 | Compound was tested for the effective dose (ED50) for each time point in Mice. 95% confidence limits are given in parentheses 24 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID239219 | Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assay | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. |
| AID50190 | Inhibition concentration by inhibition of carbonic anhydrase from brain in Rat. 95% confidence limits are given in parentheses. | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID21041 | pH 7.4 value at 7.35 pH | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID266012 | Binding affinity to human CA2 by ThermoFluor assay | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. |
| AID50188 | Inhibition concentration by inhibition of carbonic anhydrase from blood in Rat. 95% confidence limits are given in parentheses. | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID25832 | Pharmacokinetic parameter :The dissociation constant values at 25 degrees C, obtained by potentiometric titration. | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID178723 | Compound was tested for the effective dose (ED50) for each time point in Rats. 95% confidence limits are given in parentheses 12 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID112981 | Compound was tested for the effective dose (ED50) for each time point in Mice. 95% confidence limits are given in parentheses 2 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID178724 | Compound was tested for the effective dose (ED50) for each time point in Rats. 95% confidence limits are given in parentheses 16 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID19675 | Partition coefficient (logP) | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID112980 | Compound was tested for the effective dose (ED50) for each time point in Mice. 95% confidence limits are given in parentheses 16 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID139910 | Activity against maximal electroshock seizures in mice, 4 hr following oral administration of 35 mg/kg of compound | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID178866 | Compound was tested for the effective dose (ED50) for each time point in Rats. 95% confidence limits are given in parentheses 8 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID47745 | Compound was tested for inhibition of human carbonic anhydrase (hCA II) | 2003 | Bioorganic & medicinal chemistry letters, Mar-10, Volume: 13, Issue:5
| Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II. |
| AID21037 | p value at 7.35 pH | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID15879 | Partition coefficient (logP) | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID50335 | Inhibition concentration by inhibition of carbonic anhydrase from myelin in Rat. 95% confidence limits are given in parentheses. | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID139905 | Inhibition of maximal electroshock seizures in mice, 4 hr following 10 mg/kg p.o. administration. | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID15964 | Partition coefficient (logP) | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID239220 | Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. |
| AID50337 | Inhibition concentration by inhibition of carbonic anhydrase from synaptosomes in Rat. 95% confidence limits are given in parentheses. | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID23719 | Pharmacokinetic parameter :log P7.4 log P value at pH 7.4 | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID178726 | Compound was tested for the effective dose (ED50) for each time point in Rats. 95% confidence limits are given in parentheses 24 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID178722 | Compound was tested for the effective dose (ED50) for each time point in Rats. 95% confidence limits are given in parentheses 1 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID178725 | Compound was tested for the effective dose (ED50) for each time point in Rats. 95% confidence limits are given in parentheses 2 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID112979 | Compound was tested for the effective dose (ED50) for each time point in Mice. 95% confidence limits are given in parentheses 12 hr | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID50338 | Inhibition concentration of the compounds were determined by inhibition of carbonic anhydrase from kidney in Rat. 95% confidence limits are given in parentheses. | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID131508 | Effective dose against maximal electroshock seizures in mice, at 4 hr following oral administration of 10 mg/kg of compound | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID112983 | Compound was tested for the effective dose (ED50) for each time point in Mice. 95% confidence limits are given in parentheses 4 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID178864 | Compound was tested for the effective dose (ED50) for each time point in Rats. 95% confidence limits are given in parentheses 4 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID178865 | Compound was tested for the effective dose (ED50) for each time point in Rats. 95% confidence limits are given in parentheses 48 Hour | 1998 | Journal of medicinal chemistry, Apr-09, Volume: 41, Issue:8
| Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2002 | The Biochemical journal, Feb-01, Volume: 361, Issue:Pt 3
| Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 2002 | The Biochemical journal, Feb-01, Volume: 361, Issue:Pt 3
| Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate. |
| AID1796980 | CA Inhibition Assay from Article 10.1021/jm060807n: \\Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide anal | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24
| Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |