Agyria

A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.

Synonym
Lissencephaly
Broad Gyri of Cerebrum
Large Gyri of Cerebrum
Lissencephalia
Pachygyria
Macrogyria
Agyria

Excerpt	Reference
"Lissencephaly is a devastating neurological disorder caused by defective neuronal migration."	( Hirotsune, S; Kengaku, M; Miyakawa, T; Mori, D; Sato, M; Sorimachi, H; Takao, K; Takitoh, T; Umeshima, H; Wynshaw-Boris, A; Yamada, M; Yoshida, Y, 2009)
"Lissencephaly is a severe brain developmental disease in human infants, which is usually caused by mutations in either of two genes, LIS1 and DCX."	( Gräf, R; Kuhnert, O; Meyer, I, 2011)
"Lissencephaly is a rare brain malformation characterized by a smooth cerebral surface, thickened cortical mantle and microscopic evidence of incomplete neuronal migration."	( Kumar, S; Marwaha, RK; Panigrahi, I; Suthar, R, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	4 (19.05)	18.1394
2010's	14 (66.67)	28.8240
2020's	3 (14.29)	9.53

Drug	Relationship Strength	Studies
gamma-aminobutyric acid	low	1
carbamates	low	1
apnea	low	1
phenobarbital	low	1
potassium chloride	low	1
sevoflurane	low	1
thyroxine	low	1
leucine	low	1
valine	low	1
fludrocortisone	low	1
glutamic acid	low	1
aloxistatin	low	1
fluorodeoxyglucose f18	low	2
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone	low	1
leupeptins	low	2
acetylleucyl-leucyl-norleucinal	low	2
tretinoin	low	1
methylazoxymethanol acetate	low	1
snj-1945	low	1
sepharose	low	1
calpain	low	3
acyclovir	low	1
guanosine triphosphate	low	1
valacyclovir	low	1

Protein Targets (392)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Cruzipain	2	0	0	2
TDP1 protein	10	0	0	10
nuclear receptor ROR-gamma isoform 1	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
Calpain small subunit 1	0	1	0	1
Calpain-1 catalytic subunit	0	3	0	3
Cathepsin B	0	2	0	2
ATP-dependent translocase ABCB1	0	0	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Calpain-1 catalytic subunit	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	3	0	0	3
Thymidine kinase	0	1	0	1
thioredoxin reductase	6	0	0	6
phosphopantetheinyl transferase	4	0	0	4
GLS protein	3	0	0	3
Smad3	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
EWS/FLI fusion protein	3	0	0	3
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
activating transcription factor 6	2	0	0	2
Histone H2A.x	1	0	0	1
Bloom syndrome protein isoform 1	4	0	0	4
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lamin isoform A-delta10	5	0	0	5
Solute carrier family 22 member 1	0	0	0	1
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Solute carrier family 22 member 6	0	0	0	1
Bile salt export pump	0	1	0	1
Bile salt export pump	0	3	0	3
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	1	1	2
Cytochrome P450 2J2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
Thymidine kinase	0	1	0	1
calpain II, partial	0	1	0	1
ClpP	1	0	0	1
PPM1D protein	1	0	0	1
thioredoxin glutathione reductase	3	0	0	3
geminin	4	0	0	4
Papain	0	1	0	1
Interferon beta	4	0	0	4
Procathepsin L	0	1	0	1
Cathepsin G	0	1	0	1
Cathepsin G	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Neutrophil elastase	0	1	0	1
Myeloblastin	0	1	0	1
ATAD5 protein, partial	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
estrogen-related nuclear receptor alpha	3	0	0	3
D(1A) dopamine receptor	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
GALC protein	1	0	0	1
AR protein	4	0	0	4
progesterone receptor	1	0	0	1
glucocorticoid receptor [Homo sapiens]	2	0	0	2
estrogen nuclear receptor alpha	4	0	0	4
aryl hydrocarbon receptor	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
regulator of G-protein signaling 4	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
thyroid hormone receptor beta isoform a	3	0	0	3
transcriptional regulator ERG isoform 3	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peripheral myelin protein 22	2	0	0	2
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	1	2	0	3
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	1	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	1	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	1	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	1	2	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	2	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	1	2	0	3
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	2	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	2	1	4
Gamma-aminobutyric acid receptor subunit beta-3	1	2	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	1	2	1	4
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
GABA theta subunit	1	2	0	3
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	1	2	0	3
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Carbonic anhydrase 1	0	1	0	2
Carbonic anhydrase 2	0	1	0	2
Integrin beta-3	0	0	1	1
Integrin alpha-IIb	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	1	2	1	4
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	3
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
Chain A, Uracil Phosphoribosyltransferase	0	0	1	1
Chain B, Uracil Phosphoribosyltransferase	0	0	1	1
Chain C, Uracil Phosphoribosyltransferase	0	0	1	1
67.9K protein	1	0	0	1
2-dehydropantoate 2-reductase	0	0	1	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Phospholipase A-2-activating protein	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Carbonic anhydrase 9	0	1	0	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Spike glycoprotein	1	0	0	1
Calpain-2 catalytic subunit	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
RAR-related orphan receptor gamma	2	0	0	2
USP1 protein, partial	2	0	0	2
apical membrane antigen 1, AMA1	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
pregnane X nuclear receptor	2	0	0	2
G	2	0	0	2
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Transthyretin	0	1	0	2
Cellular tumor antigen p53	2	0	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	4	6
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
cytochrome P450 2C9, partial	2	0	0	2
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Luciferase	1	0	0	1
pregnane X receptor	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
GLI family zinc finger 3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
nonstructural protein 1	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
retinoid X nuclear receptor alpha	1	0	0	1
farnesoid X nuclear receptor	1	0	0	1
Parkin	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
chromobox protein homolog 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
caspase-3	1	0	0	1
heat shock protein beta-1	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Cytochrome P450 1A2	0	0	1	1
Cytochrome P450 3A4	0	0	1	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	2	0	2
Retinoic acid receptor alpha	0	2	2	7
Cytochrome P450 2D6	0	0	1	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Alpha-1D adrenergic receptor	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2C19	0	0	1	1
Nuclear receptor ROR-alpha	0	1	0	1
Alpha-synuclein	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Nuclear receptor ROR-gamma	0	1	1	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Solute carrier family 15 member 1	0	2	0	3
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(7)

Research Excerpts

Overview

Research

Studies (21)

Protein Targets (392)

Agyria

Synonyms(7)

Research Excerpts

Overview

Research

Studies (21)

Drugs Studied (27)

Protein Targets (392)