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5-oxo-pro-his-trp-ser-tyr-gly-trp-leu-pro-glynh2

Description

5-oxo-pro-his-trp-ser-tyr-gly-trp-leu-pro-glynh2: sGnRHa derivative from salmon [MeSH]

Cross-References

ID SourceID
PubMed CID121493629
MeSH IDM0164268

Synonyms (20)

Synonym
(arg(6)-trp(7)-leu(8)-pro(9)-net)gnrh
96497-82-4
lhrh, arginyl(6)-tryptophyl(7)-leucyl(8)-n-ethylprolinamide(9)-
6-arg-7-trp-8-leu-9-n-et-pronh2-lhrh
gnrh, arg(6)-trp(7)-leu(8)-n-et-pronh2(9)-
sgnrha
5-oxo-pro-his-trp-ser-tyr-gly-trp-leu-pro-glynh2
unii-whi058yg4q
l-prolinamide, 5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-d-arginyl-l-tryptophyl-l-leucyl-n-ethyl-
whi058yg4q ,
6-arginyl-7-tryptophyl-8-leucyl-9-n-ethylprolinamide-lhrh
des-gly10, d-arg6, trp7, leu8) - lhrh, ethyl amide
pglu-his-trp-ser-tyr-gly-trp-leu-pro-gly-nhet
pglu-his-trp-ser-tyr-d-arg-trp-leu-pro-nhet
[d-arg6,pro9-net]salmon gnrh
DTXSID70873506
Q27292635
sgnrh-a
CS-0615998
HY-P3582

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (23.53)18.7374
1990's7 (41.18)18.2507
2000's2 (11.76)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (11.11%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (88.89%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
gamma-aminobutyric acidamino acid zwitterion;
gamma-amino acid;
monocarboxylic acid
human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
1999199925.0low001000
domperidonebenzimidazoles;
heteroarylpiperidine
antiemetic;
dopaminergic antagonist
1988201823.8medium020110
metoclopramidebenzamides;
monochlorobenzenes;
substituted aniline;
tertiary amino compound
antiemetic;
dopaminergic antagonist;
environmental contaminant;
gastrointestinal drug;
xenobiotic
201820186.0low000010
vigabatringamma-amino acidanticonvulsant;
EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor
1999199925.0low001000
reserpinealkaloid ester;
methyl ester;
yohimban alkaloid
adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
1988198836.0low010000
thyroxine2-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine
antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
1995199529.0low001000
triiodothyronine2-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine
human metabolite;
mouse metabolite;
thyroid hormone
1995199529.0low001000
apomorphineaporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug
1998199826.0low001000
cycloheximideantibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol
anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
1993199331.0low001000
pimozidebenzimidazoles;
heteroarylpiperidine;
organofluorine compound
antidyskinesia agent;
dopaminergic antagonist;
first generation antipsychotic;
H1-receptor antagonist;
serotonergic antagonist
1988201622.0low110010
cadmiumcadmium molecular entity;
zinc group element atom
2006200618.0low000100
azidespseudohalide anionmitochondrial respiratory-chain inhibitor1990199034.0low001000
sch 23390benzazepine201820186.0low000010
ay 25,2051988198836.0medium020000
lhrh, his(5)-trp(7)-tyr(8)-2002200222.0low000100
lhrh, n-epsilon-azidobenzoyl-lys(6)-1990199034.0medium001000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020

Dosage (3)

ArticleYear
Spawning performance, serum sex steroids, and ovarian histology in wild-caught Levantine scraper, Capoeta damascina (Valenciennes, 1842) treated with various doses of sGnRHa + domperidone.
Journal of animal science, , Dec-03, Volume: 96, Issue:12
2018
Pubertal development of male African catfish (Clarias gariepinus). Pituitary ultrastructure and responsiveness to gonadotropin-releasing hormone.
Biology of reproduction, , Volume: 53, Issue:4
1995
Seasonal variations in gonadotropin responsiveness, self-priming, and desensitization to GnRH peptides in the common carp pituitary in vitro.
General and comparative endocrinology, , Volume: 93, Issue:2
1994

Interactions (1)

ArticleYear
Effects of [D-Arg6, Trp7, Leu8, Pro9NEt]-luteinizing hormone-releasing hormone (sGnRH-A) and [D-Ala6, Pro9NEt]-luteinizing hormone-releasing hormone (LHRH-A), in combination with pimozide or domperidone, on gonadotropin release and ovulation in the Chines
General and comparative endocrinology, , Volume: 69, Issue:1
1988