ay-25-205 and phorbol-12-13-didecanoate

ay-25-205 has been researched along with phorbol-12-13-didecanoate* in 1 studies

Other Studies

1 other study(ies) available for ay-25-205 and phorbol-12-13-didecanoate

Article	Year
Stimulation and inhibition of Leydig cell steroidogenesis by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate: similarity to the effects of gonadotropin-releasing hormone. Life sciences, 1985, Sep-02, Volume: 37, Issue:9 To explore the mechanism of gonadotropin-releasing hormone (GnRH) action on Leydig cell steroidogenesis the effects of a GnRH analog (GnRHa) were compared to those of 12-O-tetradecanoylphorbol 13-acetate (TPA). Both compounds acutely stimulated androgen production 2-4 fold with EC50's of 9 nM (TPA) and 0.2 nM (GnRHa). The effects of TPA and GnRHa were not additive and neither compound acutely altered the luteinizing hormone (LH) concentration-response relationship. After 24 h of exposure to TPA or GnRHa the ability of LH to stimulate androgen production was impaired. The parallel effects of TPA and GnRHa on Leydig cell steroidogenesis suggest that they are acting via similar mechanisms; presumably the activation protein kinase C. Topics: Androgens; Animals; Gonadotropin-Releasing Hormone; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate	1985

Article

Year

Stimulation and inhibition of Leydig cell steroidogenesis by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate: similarity to the effects of gonadotropin-releasing hormone.

Life sciences, 1985, Sep-02, Volume: 37, Issue:9

To explore the mechanism of gonadotropin-releasing hormone (GnRH) action on Leydig cell steroidogenesis the effects of a GnRH analog (GnRHa) were compared to those of 12-O-tetradecanoylphorbol 13-acetate (TPA). Both compounds acutely stimulated androgen production 2-4 fold with EC50's of 9 nM (TPA) and 0.2 nM (GnRHa). The effects of TPA and GnRHa were not additive and neither compound acutely altered the luteinizing hormone (LH) concentration-response relationship. After 24 h of exposure to TPA or GnRHa the ability of LH to stimulate androgen production was impaired. The parallel effects of TPA and GnRHa on Leydig cell steroidogenesis suggest that they are acting via similar mechanisms; presumably the activation protein kinase C.

Topics: Androgens; Animals; Gonadotropin-Releasing Hormone; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate

1985