Compounds > lhrh, phe(2)-trp(3)-phe(6)-
Page last updated: 2024-11-13

lhrh, phe(2)-trp(3)-phe(6)-

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

LHRH, Phe(2)-Trp(3)-Phe(6)-: gonodorelin antagonist; RN given refers to (D-Phe-D-Trp-D-Phe)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25079035
CHEMBL ID3248516
MeSH IDM0065791

Synonyms (8)

Synonym
lhrh, phenylalanyl(2)-tryptophyl(3)-phenylalanine(6)-
gnrh, phe(2)-trp(3)-phe(6)-
63722-14-5
lhrh, phe(2)-trp(3)-phe(6)-
ptp-lhrh
2-phe-3-trp-6-phe-lhrh
CHEMBL3248516
DTXSID30213146
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1136680Antiovulatory activity in Sprague-Dawley rat at 1 mg, sc administered at 12 pm on proestrous day relative to vehicle-treated control1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Branched-chain analogues of luteinizing hormone-releasing hormone.
AID1136674In vivo inhibition of LH-RH receptor in immature rat assessed as inhibition of LH-RH-stimulated luteinizing hormone release in serum at 300 ug, sc administered 1 hr prior to LH-RH addition measured after 30 mins relative to vehicle-treated control1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Branched-chain analogues of luteinizing hormone-releasing hormone.
AID1136679In vivo inhibition of LH-RH receptor in immature rat assessed as inhibition of LH-RH-stimulated follicle-stimulating hormone release in serum at 300 ug, sc administered 4 hrs prior to LH-RH addition measured after 30 mins relative to vehicle-treated contr1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Branched-chain analogues of luteinizing hormone-releasing hormone.
AID1136678In vivo inhibition of LH-RH receptor in immature rat assessed as inhibition of LH-RH-stimulated follicle-stimulating hormone release in serum at 300 ug, sc administered 1 hr prior to LH-RH addition measured after 30 mins relative to vehicle-treated contro1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Branched-chain analogues of luteinizing hormone-releasing hormone.
AID1136675In vivo inhibition of LH-RH receptor in immature rat assessed as inhibition of LH-RH-stimulated luteinizing hormone release in serum at 300 ug, sc administered 4 hrs prior to LH-RH addition measured after 30 mins relative to vehicle-treated control1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Branched-chain analogues of luteinizing hormone-releasing hormone.
AID1136681Antiovulatory activity in Sprague-Dawley rat at 1.5 mg, sc administered at 9 am on proestrous day relative to vehicle-treated control1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Branched-chain analogues of luteinizing hormone-releasing hormone.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
lhrh, leu(6)-n-et-glynh2(10)-
[no description available]		1.9510
gonadotropin-releasing hormone
relisorm L: Gonadotropin-Releasing Hormone analog. gonadorelin : A ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence.		1.9510oligopeptide;
peptide hormone		gonadotropin releasing hormone agonist
ay 25,205
surfagon: potent LHRH agonist; RN given refers to (D-Ala-L-Pro)-isomer		1.9610
lhrh, n-et-alanh2(6)-
[no description available]		1.9510
ConditionIndicatedRelationship StrengthStudiesTrials
48,XXYY Syndrome
[description not available]		01.9510
Klinefelter Syndrome
A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).		01.9510