Page last updated: 2024-11-13
lhrh, phe(2)-trp(3)-phe(6)-
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
LHRH, Phe(2)-Trp(3)-Phe(6)-: gonodorelin antagonist; RN given refers to (D-Phe-D-Trp-D-Phe)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 25079035 |
| CHEMBL ID | 3248516 |
| MeSH ID | M0065791 |
Synonyms (8)
| Synonym |
|---|
| lhrh, phenylalanyl(2)-tryptophyl(3)-phenylalanine(6)- |
| gnrh, phe(2)-trp(3)-phe(6)- |
| 63722-14-5 |
| lhrh, phe(2)-trp(3)-phe(6)- |
| ptp-lhrh |
| 2-phe-3-trp-6-phe-lhrh |
| CHEMBL3248516 |
| DTXSID30213146 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1136680 | Antiovulatory activity in Sprague-Dawley rat at 1 mg, sc administered at 12 pm on proestrous day relative to vehicle-treated control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3 | Branched-chain analogues of luteinizing hormone-releasing hormone. |
| AID1136674 | In vivo inhibition of LH-RH receptor in immature rat assessed as inhibition of LH-RH-stimulated luteinizing hormone release in serum at 300 ug, sc administered 1 hr prior to LH-RH addition measured after 30 mins relative to vehicle-treated control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3 | Branched-chain analogues of luteinizing hormone-releasing hormone. |
| AID1136679 | In vivo inhibition of LH-RH receptor in immature rat assessed as inhibition of LH-RH-stimulated follicle-stimulating hormone release in serum at 300 ug, sc administered 4 hrs prior to LH-RH addition measured after 30 mins relative to vehicle-treated contr | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3 | Branched-chain analogues of luteinizing hormone-releasing hormone. |
| AID1136678 | In vivo inhibition of LH-RH receptor in immature rat assessed as inhibition of LH-RH-stimulated follicle-stimulating hormone release in serum at 300 ug, sc administered 1 hr prior to LH-RH addition measured after 30 mins relative to vehicle-treated contro | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3 | Branched-chain analogues of luteinizing hormone-releasing hormone. |
| AID1136675 | In vivo inhibition of LH-RH receptor in immature rat assessed as inhibition of LH-RH-stimulated luteinizing hormone release in serum at 300 ug, sc administered 4 hrs prior to LH-RH addition measured after 30 mins relative to vehicle-treated control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3 | Branched-chain analogues of luteinizing hormone-releasing hormone. |
| AID1136681 | Antiovulatory activity in Sprague-Dawley rat at 1.5 mg, sc administered at 9 am on proestrous day relative to vehicle-treated control | 1978 | Journal of medicinal chemistry, Mar, Volume: 21, Issue:3 | Branched-chain analogues of luteinizing hormone-releasing hormone. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.50
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.50) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||