Page last updated: 2024-11-11

fusaproliferin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

fusaproliferin: isolated from Fusarium proliferatum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6506535
CHEMBL ID486177
MeSH IDM0246756

Synonyms (5)

Synonym
fusaproliferin
CHEMBL486177
C20591
(-)-fusaproliferin
[(2s)-2-[(1s,3e,7e,11s,12e,15r)-11,17-dihydroxy-1,4,8,12-tetramethyl-18-oxo-16-bicyclo[13.3.0]octadeca-3,7,12,16-tetraenyl]propyl] acetate

Research Excerpts

Overview

Fusaproliferin (FUS) is a mycotoxin that has toxic activity against brine shrimp, insect cells, and chicken embryos. Fusarium proliferatum is a widespread pathogen of cereals.

ExcerptReferenceRelevance
"Fusaproliferin is a toxic sesterterpene isolated from Fusarium proliferatum, a widespread pathogen of cereals. "( Structure and absolute stereochemistry of fusaproliferin, a toxic metabolite from Fusarium proliferatum.
Benedetti, E; Fogliano, V; Logrieco, A; Mannina, L; Randazzo, G; Ritieni, A; Santini, A, 1996
)
2
"Fusaproliferin (FUS) is a mycotoxin that has toxic activity against brine shrimp, insect cells, and teratogenic effects on chicken embryos."( Study of the cytotoxic activity of beauvericin and fusaproliferin and bioavailability in vitro on Caco-2 cells.
Font, G; Meca, G; Prosperini, A; Ruiz, MJ, 2012
)
1.35

Bioavailability

ExcerptReferenceRelevance
" The aim of this study was to determine the cytotoxicity of BEA and FUS in human epithelial colorectal adenocarcinoma HT-29 and Caco-2 cells, the transepithelial transport and the bioavailability using Caco-2 cells as a simulated in vitro gastrointestinal model of the human intestinal epithelium."( Study of the cytotoxic activity of beauvericin and fusaproliferin and bioavailability in vitro on Caco-2 cells.
Font, G; Meca, G; Prosperini, A; Ruiz, MJ, 2012
)
0.63
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID400347Toxicity in Artemia salina1996Journal of natural products, Feb, Volume: 59, Issue:2
Structure and absolute stereochemistry of fusaproliferin, a toxic metabolite from Fusarium proliferatum.
AID376861Toxicity against Artemia salina larvae2000Journal of natural products, Aug, Volume: 63, Issue:8
Biological characterization of fusapyrone and deoxyfusapyrone, two bioactive secondary metabolites of Fusarium semitectum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's9 (27.27)18.2507
2000's14 (42.42)29.6817
2010's9 (27.27)24.3611
2020's1 (3.03)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.22 (24.57)
Research Supply Index3.53 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other30 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]