Roles > TRPM4 channel inhibitor
Page last updated: 2024-08-05 15:32:13

TRPM4 channel inhibitor

An inhibitor of transient receptor potential cation channel subfamily M member 4.

ChEBI ID: 132608

Members (1)

MemberDefinitionClass
9-phenanthrolA phenanthrol that is phenanthrene in which a hydrogen attached to a carbon in the central ring has been replaced by a hydroxy group.9-phenanthrol

Research

Studies (63)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901 (1.59)18.7374
1990's2 (3.17)18.2507
2000's4 (6.35)29.6817
2010's41 (65.08)24.3611
2020's15 (23.81)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.59%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other62 (98.41%)84.16%

Protein Targets (38)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency63.260911
activating transcription factor 6Homo sapiens (human)Potency7.760611
AR proteinHomo sapiens (human)Potency13.667488
aryl hydrocarbon receptorHomo sapiens (human)Potency7.617822
Ataxin-2Homo sapiens (human)Potency12.197211
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency13.487222
Cellular tumor antigen p53Homo sapiens (human)Potency11.034622
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency6.859011
estrogen nuclear receptor alphaHomo sapiens (human)Potency26.78661010
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency7.041622
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency9.014766
farnesoid X nuclear receptorHomo sapiens (human)Potency9.834922
GLI family zinc finger 3Homo sapiens (human)Potency5.484422
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency28.465733
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency15.355311
heat shock protein beta-1Homo sapiens (human)Potency29.562822
histone deacetylase 9 isoform 3Homo sapiens (human)Potency43.277111
Histone H2A.xCricetulus griseus (Chinese hamster)Potency18.624422
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency10.962222
LuciferasePhotinus pyralis (common eastern firefly)Potency79.640711
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency13.134422
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency32.586222
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency25.282633
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency8.242733
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency6.328622
pregnane X nuclear receptorHomo sapiens (human)Potency13.685411
progesterone receptorHomo sapiens (human)Potency6.113111
RAR-related orphan receptor gammaMus musculus (house mouse)Potency12.683722
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency13.513733
retinoid X nuclear receptor alphaHomo sapiens (human)Potency5.814522
SMAD family member 2Homo sapiens (human)Potency7.967222
SMAD family member 3Homo sapiens (human)Potency7.967222
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency10.459233
thyroid stimulating hormone receptorHomo sapiens (human)Potency6.509422
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency48.966211
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency2.851933
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency15.355311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Transient receptor potential cation channel subfamily M member 4Homo sapiens (human)IC5029.000011