Ichthyosis Simplex

Most common form of ICHTHYOSIS characterized by prominent scaling especially on the exterior surfaces of the extremities. It is inherited as an autosomal dominant trait.

Synonym
Ichthyosis Vulgaris
Ichthyosis Simplex
Ichthyosis Vulgaris, Dominant

Excerpt	Reference
"Ichthyosis vulgaris is an epidermal disorder in which profilaggrin expression is decreased or absent."	( Blomquist, C; Brumbaugh, S; Dale, BA; Fleckman, P; Haydock, PV; Holbrook, KA, 1993)
"Ichthyosis vulgaris is a common disorder of keratinization caused by mutations in the filaggrin gene and clinically characterized by variable degree of xerosis."	( Benintende, C; Boscaglia, S; Dinotta, F; Lacarrubba, F; Micali, G, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (5.56)	23.3326
1990's	14 (38.89)	12.5806
2000's	10 (27.78)	18.1394
2010's	7 (19.44)	28.8240
2020's	3 (8.33)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	1	0
salicylic acid	low	2	0
lactic acid	low	2	0
glycerol	medium	2	1
iodine	low	1	0
nickel	low	1	0
propylene glycol	low	1	0
urea	medium	3	1
bay h 4502	low	1	0
tazarotene	low	1	0
ticlopidine	low	1	0
estrone	low	1	0
dehydroepiandrosterone	low	1	0
pilocarpine	low	1	0
histidine	low	1	0
lawsone	low	1	0
tetraethyleneglycol dimethacrylate	low	1	0
framycetin	low	1	0
pregnenolone	low	1	0
dehydroepiandrosterone sulfate	low	1	0
ammonium lactate	low	1	0
hexyl nicotinate	low	1	0
pregnenolone sulfate	low	1	0
bromochloroacetic acid	low	5	0
urocanic acid	low	1	0
terbinafine	low	2	0
estrone sulfate	low	1	0
naphthoquinones	low	1	0
sphingosine	low	1	0
calcitriol	medium	2	1
acitretin	low	1	0
calcipotriene	medium	2	1
salicylates	low	1	0
1 alpha,24-dihydroxyvitamin d3	medium	1	1

Protein Targets (442)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Luciferase	6	0	0	6
USP1 protein, partial	8	0	0	8
TDP1 protein	10	0	0	10
Microtubule-associated protein tau	5	0	0	5
AR protein	12	0	0	12
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
glucocorticoid receptor [Homo sapiens]	7	0	0	7
estrogen nuclear receptor alpha	13	0	0	13
peroxisome proliferator activated receptor gamma	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
vitamin D3 receptor isoform VDRA	4	0	0	4
thyroid hormone receptor beta isoform 2	9	0	0	9
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase PLK1	2	0	0	2
eyes absent homolog 2 isoform a	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
geminin	7	0	0	7
peripheral myelin protein 22	4	0	0	4
survival motor neuron protein isoform d	2	0	0	2
histone acetyltransferase KAT2A isoform 1	3	0	0	3
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	6	0	7
Bile salt export pump	0	3	0	3
Bile salt export pump	0	8	0	8
Rap guanine nucleotide exchange factor 3	3	0	0	3
Cellular tumor antigen p53	8	0	0	8
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Ferritin light chain	4	0	0	4
acetylcholinesterase	5	0	0	5
calpain II, partial	0	1	0	1
phosphopantetheinyl transferase	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	11	0	0	11
ATAD5 protein, partial	5	0	0	5
GLI family zinc finger 3	8	0	0	8
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
progesterone receptor	8	0	0	8
isocitrate dehydrogenase 1, partial	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
nonstructural protein 1	2	0	0	2
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	9	0	0	9
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	9	0	0	9
G	5	0	0	5
cytochrome P450 2D6	6	0	0	6
glucocerebrosidase	2	0	0	2
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
shiga toxin 1 variant A subunit	1	0	0	1
shiga toxin 1 B subunit	1	0	0	1
peroxisome proliferator-activated receptor delta	6	0	0	6
IDH1	2	0	0	2
aryl hydrocarbon receptor	3	0	0	3
thyroid stimulating hormone receptor	6	0	0	6
activating transcription factor 6	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Histone H2A.x	5	0	0	5
cellular tumor antigen p53 isoform a	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
phospholipase A2 precursor	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
heat shock protein beta-1	3	0	0	3
mitogen-activated protein kinase 1	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
DNA polymerase iota isoform a (long)	5	0	0	5
nuclear receptor ROR-gamma isoform 1	3	0	0	3
cysteine protease ATG4B isoform a	0	1	0	1
cytochrome P450 3A4 isoform 1	6	0	0	6
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	6	0	0	6
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit delta	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	6	0	0	6
Alpha-synuclein	2	1	0	3
Spike glycoprotein	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-2	6	0	0	6
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Inositol monophosphatase 1	2	0	0	2
TAR DNA-binding protein 43	3	0	0	3
Lanosterol 14-alpha demethylase	0	2	0	2
GABA theta subunit	6	0	0	6
Inositol hexakisphosphate kinase 1	5	0	0	5
Canalicular multispecific organic anion transporter 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	6	0	0	6
cytochrome P450 2C9, partial	5	0	0	5
heat shock protein 90, putative	0	0	0	1
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
Nuclear receptor ROR-gamma	2	0	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Vitamin D3 receptor	0	0	1	1
PPM1D protein	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	0	0	1
Cytochrome P450 3A4	0	2	0	3
Androgen receptor	0	1	0	1
Cytochrome P450 2D6	0	3	0	3
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	2	0	3
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	3	0	3
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Carbonic anhydrase 1	0	3	0	5
Carbonic anhydrase 2	0	3	0	5
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 15	0	2	0	3
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
chromobox protein homolog 1	7	0	0	7
Sex hormone-binding globulin	0	0	3	3
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	3	0	3
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Steryl-sulfatase	0	3	0	5
Multidrug resistance-associated protein 1	0	1	0	3
Solute carrier organic anion transporter family member 1A1	0	2	0	4
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	2
Solute carrier organic anion transporter family member 1B1	0	1	0	3
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
endonuclease IV	2	0	0	2
NFKB1 protein, partial	1	0	0	1
GALC protein	1	0	0	1
arylsulfatase A	3	0	0	3
Bloom syndrome protein isoform 1	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
lamin isoform A-delta10	8	0	0	8
Estrogen receptor	0	2	1	4
Aromatase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Androgen receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Mu-type opioid receptor	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Mu-type opioid receptor	0	0	1	1
Cytochrome P450 1B1	0	1	0	1
Estrogen receptor beta	0	1	1	3
Ghrelin O-acyltransferase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Estrogen receptor beta	0	0	0	2
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	4
Estrogen receptor	0	0	0	2
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
thyroid hormone receptor beta isoform a	2	0	0	2
Cytochrome P450 2E1	0	0	1	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	1	0	2
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	1	0	2
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 6	0	1	0	2
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
histone deacetylase 9 isoform 3	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Glutamate receptor 2	2	0	0	2
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Dihydroorotate dehydrogenase	0	1	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Genome polyprotein	0	1	0	1
Protease	0	1	0	1
Integrase	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	1	0	1
Cysteine protease	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 22	0	1	0	1
P2X purinoceptor 7	0	1	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Serine racemase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
thioredoxin reductase	2	0	0	2
GLS protein	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
Muscarinic acetylcholine receptor M2	0	1	1	2
Muscarinic acetylcholine receptor M1	0	2	0	3
Muscarinic acetylcholine receptor M3	0	2	0	3
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	3
Muscarinic acetylcholine receptor M1	0	1	2	3
Cytochrome P450 2A6	0	1	1	2
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Histamine H2 receptor	2	0	0	2
Cytochrome P450 2A13	0	1	1	2
ATP-dependent phosphofructokinase	1	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	1	2
Glutamate receptor ionotropic, NMDA 2A	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
Glutamate receptor ionotropic, NMDA 2C	0	1	1	2
Cholesterol 24-hydroxylase	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, Cruzipain	1	0	0	1
acid sphingomyelinase	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
alpha-galactosidase	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
DNA polymerase beta	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
EWS/FLI fusion protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Retinoic acid receptor alpha	0	0	1	1
Retinoic acid receptor beta	0	0	1	1
Retinoic acid receptor gamma	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-2A adrenergic receptor	0	4	0	4
Sodium-dependent noradrenaline transporter	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
glp-1 receptor, partial	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
Cytochrome P450 2C8	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Cytochrome P450 2B6	0	2	0	2
Cytochrome P450 2J2	0	1	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Research

Studies (36)

Protein Targets (442)

Ichthyosis Simplex

Synonyms(3)

Research Excerpts

Overview

Research

Studies (36)

Drugs Studied (41)

Protein Targets (442)