Compounds > thiophene-2-carboxylic acid hydrazide
Page last updated: 2024-12-06

thiophene-2-carboxylic acid hydrazide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

thiophene-2-carbohydrazide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID73098
CHEMBL ID3091844
SCHEMBL ID355263
MeSH IDM0065939

Synonyms (53)

Synonym
BIDD:GT0451
nsc-120045
nsc120045
2-thiophenecarboxylic acid hydrazide
thiophene-2-carboxylic acid hydrazide
2-thienylcarboxylic acid hydrazide
2-thiophenecarbohydrazonic acid
2361-27-5
nsc-653
2-thenoylhydrazine
nsc653
2-thiophenecarboxylic acid, hydrazide
thiophene-2-carbohydrazide
2-thiophenecarboxylic acid hydrazide, >=98%
STK061684
AKOS000200290
2-thiophenecarboxylic hydrazide
sogbogbtikmgfs-uhfffaoysa-
inchi=1/c5h6n2os/c6-7-5(8)4-2-1-3-9-4/h1-3h,6h2,(h,7,8)
T1140
HMS1722A21
2-thiophene carboxylic hydrazide
thiophene-2-carboxylic hydrazide
A816801
unii-w4j3wef93n
nsc 653
einecs 219-107-0
w4j3wef93n ,
FT-0634215
PS-5271
SCHEMBL355263
CHEMBL3091844
2-thiophenecarboxylicacidhydrazide
2thiophenecarboxylic hydrazide
2-thiophene carboxylic acid hydrazide
2-thiophencarboxylic acid hydrazide
2-thiophenecarbohydrazide
thenohydrazide
W-107392
2-thiophenecarbohydrazide #
2-thienyl hydrazide
2-thenoic hydrazide
DTXSID80178271
F3146-2497
mfcd00005435
BBL104270
thiophene-2-carboxylic hydrazone
SY048333
AM9858
F10320
EN300-17658
CS-W018291
Z56974792
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1059231Antitubercular activity against Mycobacterium tuberculosis2013European journal of medicinal chemistry, , Volume: 70Comparison of Multiple Linear Regressions and Neural Networks based QSAR models for the design of new antitubercular compounds.
AID1422882Binding affinity to recombinant Trypanosoma cruzi His/haemaglutinin-tagged BDF3 expressed in Escherichia coli BL21 at 100 uM by fluorescence spectra analysis2018ACS medicinal chemistry letters, Oct-11, Volume: 9, Issue:10
Discovery of a Biologically Active Bromodomain Inhibitor by Target-Directed Dynamic Combinatorial Chemistry.
AID1059234Lipophilicity, log P of the compound2013European journal of medicinal chemistry, , Volume: 70Comparison of Multiple Linear Regressions and Neural Networks based QSAR models for the design of new antitubercular compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (47.83)18.7374
1990's1 (4.35)18.2507
2000's1 (4.35)29.6817
2010's9 (39.13)24.3611
2020's1 (4.35)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.58 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.15 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.58)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (95.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydroxylamine
amino alcohol : An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group.		1.9610hydroxylaminesalgal metabolite;
bacterial xenobiotic metabolite;
EC 1.1.3.13 (alcohol oxidase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
nitric oxide donor;
nucleophilic reagent
pyrazinamide
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.		1.9610monocarboxylic acid amide;
N-acylammonia;
pyrazines		antitubercular agent;
prodrug
vanillin
Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).		2.1710benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
4-hydroxybenzoic acid hydrazide
4-hydroxybenzoic acid hydrazide: metabolite of nifuroxazide. 4-hydroxybenzohydrazide : A carbohydrazide obtained by formal condensation of the carboxy group of 4-hydroxybenzoic acid with hydrazine.		2.0810carbohydrazide;
phenols
iproniazid
[no description available]		2.0810carbohydrazide;
pyridines
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		3.0750carbohydrazideantitubercular agent;
drug allergen
4-nitrobenzoic acid
4-nitrobenzoic acid: RN given refers to parent cpd. 4-nitrobenzoic acid : A nitrobenzoic acid having the nitro group at the 4-position.		1.9710nitrobenzoic acid
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		4.28190mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
hydrazine
diamine : Any polyamine that contains two amino groups.		2.5520azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
nicotinic acid hydrazide
nicotinic acid hydrazide: structural homolog of isoniazid; structure given in first source		2.0810
benzoylhydrazine
benzoylhydrazine: inhibits copper-depleted bovine serum amine oxidase		2.0810carbohydrazide
acetylhydrazine
acetylhydrazine: metabolite of isoniazid in animals and humans; RN given refers to parent cpd. acetohydrazide : A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.		2.0810carbohydrazide;
carbohydrazonic acid		drug metabolite
2-furoic acid hydrazide
2-furoylhydrazine: used for determination of carbohydrates		2.0810
4-aminobenzhydrazide
4-aminobenzhydrazide: a Russian synthetic drug of acylhydrazide group; decreased uterus wt in rats; RN given refers to cpd with specified locants for amino group		2.0810
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		2.1710C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
4-nitro-alpha-acetylamino-beta-hydroxypropiophenone
4-nitro-alpha-acetylamino-beta-hydroxypropiophenone: inhibitory agent for the differentiation of mammalian tuberculosis strains from other Mycobacteria		1.9710
acetylisoniazid
acetylisoniazid: Antitubercular Agent. N'-acetylisoniazid : A carbohydrazide resulting from the formal condensation of the carboxy group of isonicotinic acid with hydrazine and subsequent acetylation of the monosubstituted nitrogen atom.		2.0810carbohydrazidemetabolite
succinic dihydrazide
succinic dihydrazide: structure given in first source		2.0810
n,n'-diacetylhydrazine
[no description available]		2.0810carbohydrazide
carbohydrazide
carbohydrazide: structure. carbohydrazide : A hydrazide consisting of hydrazine carrying one or more carboacyl groups.. carbonyl dihydrazine : A carbohydrazide obtained by formal condensation between hydrazinecarboxylic acid and hydrazine.		2.110carbohydrazide;
one-carbon compound
4-methoxybenzohydrazide
4-methoxybenzohydrazide: structure in first source		2.0810
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		2.2510cobalt group element atom;
metal allergen		micronutrient
3-nitrobenzhydrazide
[no description available]		2.0810
nifurtimox
Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.		2.1710nitrofuran antibiotic
phthivazide
[no description available]		2.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Koch's Disease
[description not available]		02.6730
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.6730
Pulmonary Consumption
[description not available]		01.9610
Tuberculosis, Pulmonary
MYCOBACTERIUM infections of the lung.		01.9610
Tuberculosis, Bovine
An infection of cattle caused by MYCOBACTERIUM BOVIS. It is transmissible to man and other animals.		01.9810