fluorapatite and Bone-Diseases

Topics: Acute Disease; Adult; Apatites; Bone and Bones; Bone Diseases; Humans; Hydrocarbons, Fluorinated; Inhalant Abuse; Male; Solvents

The removal of certain deformities of facial bones is a prerequisite to a restoration of function, stability, and appearance. Synthetic bone substitutes are beneficial in cases where other operative technique would represent an inadequate burden for a patient. A result is achieved in one surgical intervention with low costs and low demands on technical equipment. Biocompatible nonresorbable glass-ceramics based on oxyfluoroapatite and wollastonite presenting osteoconductivity permits osteointegration, i.e., direct physicochemical bonds between live bone tissue and the implant without formation of a fibrous capsule. It presents better durability to stress in simulated body fluid than the usually used hydroxyapatite. It was used for restoration of facial skeletal framework contour in 14 cases under conditions where prior solutions were doubtful. Good results were reached in all patients. The mean time of observation was 18 months. During that period, the rate of complications was 14.3%. This approach may be found to be a suitable technique, especially for patients exhausted by prior unsuccessful treatment but still not acquiesced in a result.

Topics: Adult; Apatites; Biocompatible Materials; Bone Diseases; Bone Substitutes; Calcium Compounds; Ceramics; Chemical Phenomena; Chemistry, Physical; Craniofacial Abnormalities; Crystallization; Facial Asymmetry; Facial Bones; Female; Follow-Up Studies; Glass; Goldenhar Syndrome; Humans; Mandibulofacial Dysostosis; Osseointegration; Osteogenesis; Postoperative Complications; Silicates; Treatment Outcome

The beneficial effect of fluoride to tooth enamel and its potentially harmful effect on bone, may be explained by simple and similar mechanisms. In individuals whose skeletal tissues contain higher than normal levels of fluoride there is a possibility that during resorptive and remodeling processes, bone (and bone marrow) cells may be exposed to genotoxic and lethal levels of fluoride. The success of fluoride as a preventive against dental caries does not mean that unnecessary exposure to the element should be tolerated. Total daily fluoride intake from a multiplicity of possible everyday sources should be monitored; and the assumption that sodium fluoride is safe to use as an anti-caries agent, particularly for expectant mothers and children, should be reviewed.

Topics: Absorption; Apatites; Body Weight; Bone and Bones; Bone Diseases; Bone Resorption; Crystallization; Dental Caries; Dental Enamel; Durapatite; Fluorides; Humans; Hydroxyapatites; Kidney; Models, Biological; Osteoclasts; Osteocytes; Time Factors