hydroxymethanediphosphonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Hydroxymethanediphosphonic acid (HMDP) is an organophosphorus compound with the formula (HO)2P(O)CH2P(O)(OH)2. It is a colorless solid that is soluble in water. HMDP is a chelating agent that is used in a variety of industrial and biological applications.

HMDP is typically synthesized by the reaction of formaldehyde with phosphorous acid in the presence of a base. The reaction is exothermic and proceeds with high yield.

HMDP has been shown to have a number of biological effects, including inhibition of calcium phosphate precipitation, inhibition of bone resorption, and anti-inflammatory activity.

These properties have led to the development of HMDP as a drug for the treatment of a variety of diseases, including osteoporosis, Paget's disease, and hypercalcemia. HMDP is also being investigated for its potential use in the treatment of cancer, Alzheimer's disease, and other conditions.

HMDP is studied extensively because of its versatile properties and its potential applications in various fields. Its ability to chelate metals and its biological effects have made it a subject of interest for researchers in areas such as medicine, agriculture, and environmental science. It is a relatively stable compound, making it suitable for a variety of applications.

It is important to note that the use of HMDP is subject to regulatory oversight due to its potential toxicity.'

hydroxymethanediphosphonic acid: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	27304
CHEMBL ID	1615775
CHEBI ID	134844
SCHEMBL ID	393281
MeSH ID	M0093500

Synonyms (43)

Synonym
oxidronic acid
phosphonic acid, (hydroxymethylene)bis-
oxidronic acid (usan)
15468-10-7
D05296
[hydroxy(phosphono)methyl]phosphonic acid
CHEBI:134844
hydroxymethanediphosphonic acid
unii-71mr4v32ti
acide oxidronique [inn-french]
oxidronsaeure
(hydroxymethylene)diphosphonic acid
acido oxidronico [inn-spanish]
acidum oxidronicum
oxidronic acid [usan:inn:ban]
acidum oxidronicum [inn-latin]
(hydroxymethylene)disphosphonic acid
hmdp
acide oxidronique
acido oxidronico
(hydroxymethylen)diphosphonsaeure
71mr4v32ti ,
oxidronate
CHEMBL1615775
hmd-p
oxidronic acid [mi]
oxidronic acid [inn]
oxidronate [vandf]
oxidronic acid [who-dd]
oxidronic acid [mart.]
oxidronic acid [usan]
hydroxymethane diphosphonate
SCHEMBL393281
DTXSID10165699 ,
FT-0700046
DB14159
Q27265970
EN300-23016152
oxidronic acid (mart.)
acide oxidronique (inn-french)
acido oxidronico (inn-spanish)
acidum oxidronicum (inn-latin)
dtxcid3088190

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
1,1-bis(phosphonic acid)	Any member of the class of phosphonic acids in which a carbon atom is directly attached to two phosphonic acid groups. They are analogues of pyrophosphates (with the central oxygen atom replaced by a carbon atom) and like pyrophosphates they tend to have a strong affinity for bone, so are frequently used for their antiresorptive and hypocalcaemic properties.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (34)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	12 (35.29)	18.7374
1990's	4 (11.76)	18.2507
2000's	6 (17.65)	29.6817
2010's	6 (17.65)	24.3611
2020's	6 (17.65)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.10

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.10 (24.57)
Research Supply Index	3.66 (2.92)
Research Growth Index	4.76 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.10)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (5.56%)	5.53%
Reviews	3 (8.33%)	6.00%
Case Studies	1 (2.78%)	4.05%
Observational	0 (0.00%)	0.25%
Other	30 (83.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.42	2	0	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
citric acid, anhydrous Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.. citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.	2.11	1	0	tricarboxylic acid	antimicrobial agent; chelator; food acidity regulator; fundamental metabolite
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.48	2	0	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
triphosphoric acid triphosphoric acid: used as water softener, peptizing agent, emulsifier & dispersing agent; ingredient of cleansers; meat preservative; RN given refers to parent cpd; structure	1.96	1	0	acyclic phosphorus acid anhydride; phosphorus oxoacid
diphosphoric acid diphosphoric acid : An acyclic phosphorus acid anhydride obtained by condensation of two molecules of phosphoric acid.	4.83	3	0	acyclic phosphorus acid anhydride; phosphorus oxoacid	Escherichia coli metabolite
etidronate Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.. etidronic acid : A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.	2.38	2	0	1,1-bis(phosphonic acid)	antineoplastic agent; bone density conservation agent; chelator
pamidronate [no description available]	2.87	1	0	phosphonoacetic acid
sodium fluoride [no description available]	4.08	3	1	fluoride salt	mutagen
edetic acid Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.	2.11	1	0	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector
acrylic acid acrylic acid: RN given refers to parent cpd. acrylic acid : A alpha,beta-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.	2.4	2	0	alpha,beta-unsaturated monocarboxylic acid	metabolite
durapatite Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).	2.05	1	0
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	2	1	0	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient
rhenium Rhenium: A metal, atomic number 75, atomic weight 186.207, symbol Re.	2	1	0	manganese group element atom
technetium Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.	4.48	5	1	manganese group element atom
tricalcium phosphate tricalcium phosphate: a form of tricalcium phosphate used as bioceramic bone replacement material; see also records for alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium phosphate; apatitic tricalcium phosphate Ca9(HPO4)(PO4)5(OH) is the calcium orthophosphate leading to beta tricalcium phosphate Ca3(PO4)2 (b-TCP). calcium phosphate : A calcium salt composed of calcium and phosphate/diphosphate ions; present in milk and used for the mineralisation of calcified tissues.	2.45	2	0	calcium phosphate
fluorides [no description available]	2.91	4	0	halide anion; monoatomic fluorine
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.41	2	0	benzenes; phenyl acetates
potassium phosphate potassium phosphate: used in dental materials and to treat hypophosphatemia; RN given refers to cpd with unspecified MF. tripotassium phosphate : An inorganic potassium salt that is the tripotassium salt of phosphoric acid.	1.98	1	0	inorganic phosphate salt; inorganic potassium salt
fluorophosphate fluorophosphate: inhibits Phosphorylas phosphatase irreversibly; RN given refers to parent cpd	1.96	1	0	fluorine molecular entity; phosphoric acid derivative
fluorodeoxyglucose f18 Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)	3.92	2	0	2-deoxy-2-((18)F)fluoro-D-glucose; 2-deoxy-2-fluoro-aldehydo-D-glucose
zoledronic acid Zoledronic Acid: An imidobisphosphonate inhibitor of BONE RESORPTION that is used for the treatment of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.. zoledronic acid : An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.	2.41	1	0	1,1-bis(phosphonic acid); imidazoles	bone density conservation agent
calcium phosphate, dibasic, dihydrate calcium phosphate, dibasic, dihydrate: Molecular formula CaHPO(4)-2(H2O)	2.05	1	0	calcium salt; hydrate
rhenium-186 hedp rhenium-186 HEDP: used as a complement to analgesic therapy in patients with painful disseminated bone metastases	2	1	0
imidodiphosphonic acid imidodiphosphonic acid: in combination with technetrium, a superior radiopharmaceutical for myocardial infarct imaging; RN given refers to parent cpd	1.97	1	0
technetium tc 99m etidronate [no description available]	1.96	1	0
octacalcium phosphate octacalcium phosphate: RN given refers to cpd with MF of Ca4-(H3PO4)3; see also record for synthos (beta-tricalcium phosphate) & calcium phosphate	2.05	1	0
technetium tc 99m n-(methylamino)methylene diphosphonate technetium Tc 99m N-(methylamino)methylene diphosphonate: structure given in first source	1.96	1	0
pyrophosphate Diphosphates: Inorganic salts of phosphoric acid that contain two phosphate groups.	3.84	3	0	diphosphate ion
tamoxifen [no description available]	2	1	0	stilbenoid; tertiary amino compound	angiogenesis inhibitor; antineoplastic agent; bone density conservation agent; EC 1.2.3.1 (aldehyde oxidase) inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; estrogen antagonist; estrogen receptor antagonist; estrogen receptor modulator
strontium radioisotopes Strontium Radioisotopes: Unstable isotopes of strontium that decay or disintegrate spontaneously emitting radiation. Sr 80-83, 85, and 89-95 are radioactive strontium isotopes.	1.96	1	0
technetium tc 99m pyrophosphate Technetium Tc 99m Pyrophosphate: A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.	3.51	1	0
fluorapatite fluorapatite: RN refers to fluorapatite [Ca5F(PO4)3]). apatite : A phosphate mineral with the general formula Ca5(PO4)3X where X = OH, F or Cl.. fluorapatite : A phosphate mineral with the formula Ca5(PO4)3F.	2.05	1	0
methylcellulose Methylcellulose: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.	2.05	1	0
agar Agar: A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.. agar : A complex mixture of polysaccharides extracted from species of red algae. Its two main components are agarose and agaropectin. Agarose is the component responsible for the high-strength gelling properties of agar, while agaropectin provides the viscous properties.	1.98	1	0
technetium tc 99m medronate Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.	4.52	5	1

Condition	Relationship Strength	Studies	Trials
Cardiomyopathies, Primary [description not available]	4.28	2	0
Amyloidosis A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.	4.28	2	0
Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).	4.28	2	0
Bisphosphonate Osteonecrosis [description not available]	2.41	1	0
Amyloid Neuropathy Type 1 [description not available]	3.93	2	0
Amyloid Neuropathies, Familial Inherited disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. The different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (PREALBUMIN); APOLIPOPROTEIN A-I; and GELSOLIN.	3.93	2	0
Chills The sudden sensation of being cold. It may be accompanied by SHIVERING.	2.6	1	0
Cold Fingers, Hereditary [description not available]	2.6	1	0
Raynaud Disease An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.	2.6	1	0
Bone Cancer [description not available]	6.87	8	1
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	6.87	8	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	6.55	5	1
Caries, Dental [description not available]	3.69	10	0
Demineralization, Tooth [description not available]	2.72	3	0
Dental Caries Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	3.69	10	0
Breast Cancer [description not available]	4.99	4	0
Cancer of Prostate [description not available]	4.99	4	0
Breast Neoplasms Tumors or cancer of the human BREAST.	4.99	4	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	4.99	4	0
Bone Loss, Osteoclastic [description not available]	2.87	1	0
Metastase [description not available]	2	1	0
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2	1	0
Soft Tissue Neoplasms Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.	2	1	0
Milk-Alkali Syndrome [description not available]	2	1	0
Chronic Kidney Failure [description not available]	2	1	0
Hypercalcemia Abnormally high level of calcium in the blood.	2	1	0
Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	2	1	0

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