Page last updated: 2024-12-06

hydroxymethanediphosphonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Hydroxymethanediphosphonic acid (HMDP) is an organophosphorus compound with the formula (HO)2P(O)CH2P(O)(OH)2. It is a colorless solid that is soluble in water. HMDP is a chelating agent that is used in a variety of industrial and biological applications.

HMDP is typically synthesized by the reaction of formaldehyde with phosphorous acid in the presence of a base. The reaction is exothermic and proceeds with high yield.

HMDP has been shown to have a number of biological effects, including inhibition of calcium phosphate precipitation, inhibition of bone resorption, and anti-inflammatory activity.

These properties have led to the development of HMDP as a drug for the treatment of a variety of diseases, including osteoporosis, Paget's disease, and hypercalcemia. HMDP is also being investigated for its potential use in the treatment of cancer, Alzheimer's disease, and other conditions.

HMDP is studied extensively because of its versatile properties and its potential applications in various fields. Its ability to chelate metals and its biological effects have made it a subject of interest for researchers in areas such as medicine, agriculture, and environmental science. It is a relatively stable compound, making it suitable for a variety of applications.

It is important to note that the use of HMDP is subject to regulatory oversight due to its potential toxicity.'

hydroxymethanediphosphonic acid: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID27304
CHEMBL ID1615775
CHEBI ID134844
SCHEMBL ID393281
MeSH IDM0093500

Synonyms (43)

Synonym
oxidronic acid
phosphonic acid, (hydroxymethylene)bis-
oxidronic acid (usan)
15468-10-7
D05296
[hydroxy(phosphono)methyl]phosphonic acid
CHEBI:134844
hydroxymethanediphosphonic acid
unii-71mr4v32ti
acide oxidronique [inn-french]
oxidronsaeure
(hydroxymethylene)diphosphonic acid
acido oxidronico [inn-spanish]
acidum oxidronicum
oxidronic acid [usan:inn:ban]
acidum oxidronicum [inn-latin]
(hydroxymethylene)disphosphonic acid
hmdp
acide oxidronique
acido oxidronico
(hydroxymethylen)diphosphonsaeure
71mr4v32ti ,
oxidronate
CHEMBL1615775
hmd-p
oxidronic acid [mi]
oxidronic acid [inn]
oxidronate [vandf]
oxidronic acid [who-dd]
oxidronic acid [mart.]
oxidronic acid [usan]
hydroxymethane diphosphonate
SCHEMBL393281
DTXSID10165699 ,
FT-0700046
DB14159
Q27265970
EN300-23016152
oxidronic acid (mart.)
acide oxidronique (inn-french)
acido oxidronico (inn-spanish)
acidum oxidronicum (inn-latin)
dtxcid3088190
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
1,1-bis(phosphonic acid)Any member of the class of phosphonic acids in which a carbon atom is directly attached to two phosphonic acid groups. They are analogues of pyrophosphates (with the central oxygen atom replaced by a carbon atom) and like pyrophosphates they tend to have a strong affinity for bone, so are frequently used for their antiresorptive and hypocalcaemic properties.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (34)

TimeframeStudies, This Drug (%)All Drugs %
pre-199012 (35.29)18.7374
1990's4 (11.76)18.2507
2000's6 (17.65)29.6817
2010's6 (17.65)24.3611
2020's6 (17.65)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.10

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.10 (24.57)
Research Supply Index3.66 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.10)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (5.56%)5.53%
Reviews3 (8.33%)6.00%
Case Studies1 (2.78%)4.05%
Observational0 (0.00%)0.25%
Other30 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]