Page last updated: 2024-09-27

Endocardial Cushion Defects

A spectrum of septal defects involving the ATRIAL SEPTUM; VENTRICULAR SEPTUM; and the atrioventricular valves (TRICUSPID VALVE; BICUSPID VALVE). These defects are due to incomplete growth and fusion of the ENDOCARDIAL CUSHIONS which are important in the formation of two atrioventricular canals, site of future atrioventricular valves.

Synonyms(1)

Synonym
Endocardial Cushion Defects

Research

Studies (28)

TimeframeStudies, This Condition (%)All Conditions %
pre-19905 (17.86)23.3326
1990's11 (39.29)12.5806
2000's9 (32.14)18.1394
2010's3 (10.71)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
nitrates0low10
carbamazepine0low10
fentanyl0low10
hydralazine0low10
phentolamine0low10
arginine0low10
trichloroethylene0low20
methylprednisolone0medium21
transferrin0low10
captopril0low10
remifentanil0low10
5-bromo-4-chloro-3-indolyl beta-galactoside0low10
medigoxin0low10
tretinoin0low60
enalapril0low10
phosphocreatine0low10
piperidines0low10
transforming growth factor beta0low20
chondroitin sulfates0low10
cyclic gmp0low10
folic acid0low10

Protein Targets (340)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase3003
phosphopantetheinyl transferase5005
NFKB1 protein, partial1001
GLS protein4004
thyroid stimulating hormone receptor4004
alpha-galactosidase2002
euchromatic histone-lysine N-methyltransferase 27007
cytochrome P450 2C19 precursor1001
chromobox protein homolog 14004
flap endonuclease 11001
DNA polymerase iota isoform a (long)2002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
Cytochrome P450 3A40012
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase4004
Chain A, angiotensin converting enzyme0101
Chain A, angiotensin converting enzyme0101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase4004
15-lipoxygenase, partial1001
Microtubule-associated protein tau2002
Thrombopoietin2002
AR protein8008
thioredoxin glutathione reductase2002
cytochrome P450 family 3 subfamily A polypeptide 44004
Metallo-beta-lactamase type 20112
peripheral myelin protein 22 isoform 11001
M-phase phosphoprotein 82002
transient receptor potential cation channel subfamily V member 11001
lamin isoform A-delta105005
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40507
Bile salt export pump0808
Prothrombin0101
Renin0101
Neprilysin0101
Neprilysin0101
Leukotriene A-4 hydrolase0213
EEF1AKMT4-ECE2 readthrough transcript protein0101
Angiotensin-converting enzyme 0314
Angiotensin-converting enzyme0506
Leukotriene A-4 hydrolase0101
Thymidine phosphorylase0011
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 20101
Endothelin-converting enzyme 10101
Succinyl-diaminopimelate desuccinylase0303
Angiotensin-converting enzyme0303
Solute carrier family 15 member 10202
Beta-lactamase TEM0101
Mu-type opioid receptor0213
TAR DNA-binding protein 431001
Beta-lactamase 0203
Canalicular multispecific organic anion transporter 10505
Beta-lactamase 0202
Angiotensin-converting enzyme 2 0202
Beta-lactamase class B VIM-2 0112
Chain A, Beta-lactamase2002
acetylcholinesterase2002
RAR-related orphan receptor gamma4004
USP1 protein, partial4004
TDP1 protein5005
glucocorticoid receptor [Homo sapiens]6006
retinoic acid nuclear receptor alpha variant 13003
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha7007
IDH12002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 24004
mitogen-activated protein kinase 11001
geminin4004
Vpr1001
Bile salt export pump0202
Albumin0011
Major prion protein0011
Cellular tumor antigen p535005
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0213
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20202
Potassium voltage-gated channel subfamily H member 20404
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
P2X purinoceptor 40101
Phosphodiesterase 0101
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
endonuclease IV1001
nuclear receptor subfamily 1, group I, member 32002
farnesoid X nuclear receptor3003
peripheral myelin protein 224004
histone acetyltransferase KAT2A isoform 12002
Type-2 angiotensin II receptor0101
Solute carrier family 15 member 10101
Solute carrier organic anion transporter family member 1A10001
Multidrug and toxin extrusion protein 10202
Luciferase3003
potassium voltage-gated channel subfamily H member 2 isoform d2002
Solute carrier family 22 member 1 0101
Nuclear receptor subfamily 1 group I member 20022
ATP-dependent translocase ABCB10101
D(2) dopamine receptor0101
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Mu-type opioid receptor0314
Kappa-type opioid receptor0101
Histamine H1 receptor0202
Mu-type opioid receptor0213
D(3) dopamine receptor0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
glp-1 receptor, partial1001
GLI family zinc finger 34004
aldehyde dehydrogenase 1 family, member A14004
retinoid X nuclear receptor alpha4004
glucocerebrosidase1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
activating transcription factor 64004
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase beta1001
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein1102
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
estrogen receptor 2 (ER beta)2002
EWS/FLI fusion protein2002
aryl hydrocarbon receptor2002
thyrotropin-releasing hormone receptor2002
thyroid hormone receptor beta isoform 23003
nuclear factor erythroid 2-related factor 2 isoform 14004
Solute carrier family 22 member 60101
Carbonic anhydrase 120102
Carbonic anhydrase 10203
Carbonic anhydrase 20203
Albumin0101
Carbonic anhydrase 30101
Glucose-6-phosphate 1-dehydrogenase0101
Carbonic anhydrase 40203
Carbonic anhydrase 60102
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
6-phosphogluconate dehydrogenase, decarboxylating0101
Spike glycoprotein2002
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90102
Carbonic anhydrase 130102
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140102
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Carbonic anhydrase 5B, mitochondrial0102
ATAD5 protein, partial2002
Parkin2002
arylsulfatase A2002
pyruvate kinase1001
cytochrome P450 2D6 isoform 12002
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a1001
ras-related protein Rab-9A1001
nuclear receptor ROR-gamma isoform 12002
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 12002
pyruvate kinase PKM isoform b1001
Gamma-aminobutyric acid receptor subunit pi2002
N-glycosylase/DNA lyase0101
Integrin beta-31001
Myeloperoxidase0101
Integrin alpha-IIb1001
Ornithine decarboxylase1002
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-12002
Aspartate aminotransferase, cytoplasmic0101
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Lactoperoxidase0101
GABA theta subunit2002
Ataxin-25005
Gamma-aminobutyric acid receptor subunit epsilon2002
Single-stranded DNA cytosine deaminase1001
peroxisome proliferator activated receptor gamma2002
ATPase family AAA domain-containing protein 53003
hypoxia-inducible factor 1 alpha subunit2002
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
progesterone receptor1001
nonstructural protein 12002
G2002
bromodomain adjacent to zinc finger domain 2B3003
nuclear receptor subfamily 1, group I, member 21001
muscleblind-like protein 1 isoform 11001
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Inositol hexakisphosphate kinase 12002
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial2002
Carbonic anhydrase0101
Sodium/iodide cotransporter0101
Carbonic anhydrase 150101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
ClpP1001
Hsf1 protein0011
regulator of G-protein signaling 42002
cytochrome P450 2D61001
D(1A) dopamine receptor1001
estrogen receptor beta isoform 10101
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Alpha-1A adrenergic receptor0011
5-hydroxytryptamine receptor 40202
Alpha-2A adrenergic receptor0214
Cytochrome P450 2D60112
Alpha-1B adrenergic receptor0426
Alpha-2B adrenergic receptor0214
Alpha-1A adrenergic receptor0202
Alpha-2C adrenergic receptor0214
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0224
Alpha-2C adrenergic receptor0224
Alpha-2A adrenergic receptor0224
Alpha-1D adrenergic receptor0326
Alpha-1D adrenergic receptor0213
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Adenosine receptor A2a0011
Alpha-1A adrenergic receptor0213
Alpha-1B adrenergic receptor0213
5-hydroxytryptamine receptor 2B0404
Alpha-1A adrenergic receptor0426
Nuclear receptor subfamily 3 group C member 3 0202
Nischarin0101
Chain A, Nuclear Receptor ROR-beta0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain1001
pregnane X receptor1001
peroxisome proliferator-activated receptor delta1001
thyroid stimulating hormone receptor1001
Caspase-71001
Bloom syndrome protein isoform 11001
vitamin D3 receptor isoform VDRA1001
caspase-31001
heat shock protein beta-11001
DNA polymerase kappa isoform 11001
Voltage-dependent calcium channel gamma-2 subunit1001
Ornithine decarboxylase0001
Amyloid-beta precursor protein0101
Cytochrome P450 1A20011
60 kDa chaperonin0101
Adenosine receptor A30202
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Retinoic acid receptor gamma0123
5-hydroxytryptamine receptor 1A0101
Glutamate receptor 21001
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190011
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
Nuclear receptor ROR-gamma0112
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
interleukin 81001
caspase-1 isoform alpha precursor1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]