Page last updated: 2024-09-27

Abnormal Spermatozoa

Conditions in which sperm show abnormal morphology.

Synonyms(4)

Synonym
Teratozoospermia
Teratospermia
Globozoospermia
Abnormal Spermatozoa

Research Excerpts

Overview

ExcerptReference
"Teratozoospermia is characterised by the presence of spermatozoa with abnormal morphology."( Atshan, M; Hosseini, SH; Kakavand, K; Mohseni Meybodi, A; Sabbaghian, M; Sadighi Gilani, MA, 2020)

Treatment

ExcerptReference
"Fifty patients with asthenospermia and teratospermia meeting the inclusion criteria were randomly divided into a blank control (n = 10) and a medication group (n = 40), the former provided with fertility guidance and the latter treated with Jujing Decoction combined with lipoic acid."( Chang, FJ; Chen, Y; Fan, Q; Han, ZY; Sun, ZX; Xue, JG, 2022)

Research

Studies (20)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's12 (60.00)28.8240
2020's8 (40.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetylcarnitine0medium11
beta-alanine0low10
carnitine0low10
glycine0low10
thioctic acid0medium11
melatonin0low10
taurine0low10
letrozole0medium11
glutamine0low10
asparagine0low10
valine0low10
tryptophan0low10
alpha-chlorohydrin0low10
malondialdehyde0low20
acetylcysteine0low10
paraquat0low10
molybdenum0low10
isomethyleugenol0low10
enclomiphene0medium21
tamoxifen0low10
coenzyme q100low10
cysteine0low10
selenium0medium11
sq-233770low10
ubiquinone0low10
chromomycin a30low10

Protein Targets (390)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
acetylcholinesterase3003
dopamine D1 receptor1001
15-lipoxygenase, partial2002
pregnane X receptor2002
phosphopantetheinyl transferase5005
RAR-related orphan receptor gamma5005
USP1 protein, partial3003
NFKB1 protein, partial1001
Microtubule-associated protein tau3003
Thrombopoietin1001
AR protein7007
regulator of G-protein signaling 45005
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha3003
farnesoid X nuclear receptor2002
estrogen nuclear receptor alpha6006
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
arylsulfatase A5005
euchromatic histone-lysine N-methyltransferase 27007
Bloom syndrome protein isoform 16006
D(1A) dopamine receptor2002
thyroid hormone receptor beta isoform a2002
thyroid hormone receptor beta isoform 22002
heat shock protein beta-12002
flap endonuclease 13003
geminin5005
peripheral myelin protein 222002
survival motor neuron protein isoform d1001
muscarinic acetylcholine receptor M12002
Histone deacetylase 30101
Solute carrier family 22 member 60101
Histone deacetylase 40101
Guanine nucleotide-binding protein G1001
Histone deacetylase 10101
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Ataxin-22002
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
ATP-dependent phosphofructokinase5005
nuclear factor erythroid 2-related factor 2 isoform 14004
Cellular tumor antigen p535005
Carbonic anhydrase 10003
Carbonic anhydrase 20104
Neutral amino acid transporter A0202
Neutral amino acid transporter B(0)0202
Carbonic anhydrase-like protein, putative0003
Amino acid transporter0202
lethal factor (plasmid)2002
Cytochrome P450 3A40202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0101
Glutamate receptor ionotropic, NMDA 1 0315
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0315
Glutamate receptor ionotropic, NMDA 2B0315
Glutamate receptor ionotropic, NMDA 2C0315
Glutamate receptor ionotropic, NMDA 2D0315
Proton-coupled amino acid transporter 10303
Glutamate receptor ionotropic, NMDA 3B0315
Sodium- and chloride-dependent GABA transporter 20101
Glutamate receptor ionotropic, NMDA 3A0315
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Bile salt export pump0404
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
lamin isoform A-delta105005
Chain A, Beta-lactamase3003
glp-1 receptor, partial1001
chaperonin-containing TCP-1 beta subunit homolog1001
TDP1 protein2002
Smad31001
bromodomain adjacent to zinc finger domain 2B4004
IDH13003
ubiquitin-conjugating enzyme E2 N0202
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
nuclear receptor ROR-gamma isoform 13003
5-hydroxytryptamine receptor 40404
Epidermal growth factor receptor0202
Estrogen receptor0517
Receptor tyrosine-protein kinase erbB-20202
Tyrosine-protein kinase Fyn0202
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0404
Adenosine receptor A30404
Cytochrome P450 2D60202
Muscarinic acetylcholine receptor M10404
Beta-3 adrenergic receptor0404
Alpha-1B adrenergic receptor0404
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0202
Muscarinic acetylcholine receptor M30404
Substance-K receptor0404
Prostaglandin G/H synthase 10202
Sodium-dependent noradrenaline transporter 0404
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
Sodium-dependent serotonin transporter0404
C-8 sterol isomerase0202
D(3) dopamine receptor0404
Alpha-synuclein2002
5-hydroxytryptamine receptor 2B0404
Alpha-1A adrenergic receptor0505
5-hydroxytryptamine receptor 60404
Sodium-dependent dopamine transporter 0404
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0314
Sigma non-opioid intracellular receptor 10404
Chain A, Glutamine Binding Protein0011
thioredoxin reductase3003
GLS protein2002
peripheral myelin protein 22 isoform 13003
Asc-type amino acid transporter 10101
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10303
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
estrogen-related nuclear receptor alpha4004
thyroid stimulating hormone receptor3003
cytochrome P450 family 3 subfamily A polypeptide 41001
EWS/FLI fusion protein3003
G1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
cytochrome P450 2C19 precursor2002
runt-related transcription factor 1 isoform AML1b1001
vitamin D3 receptor isoform VDRA2002
core-binding factor subunit beta isoform 21001
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3003
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
Steryl-sulfatase0101
Aromatase0303
Gamma-aminobutyric acid receptor subunit beta-13003
Cytochrome P450 11B1, mitochondrial0101
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Cytochrome P450 11B2, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Amine oxidase [flavin-containing] A 0101
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
GABA theta subunit3003
Inositol hexakisphosphate kinase 11001
Gamma-aminobutyric acid receptor subunit epsilon3003
cytochrome P450 2C9, partial1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
interleukin 81001
ClpP1001
ATAD5 protein, partial1001
GLI family zinc finger 34004
caspase 7, apoptosis-related cysteine protease2002
aldehyde dehydrogenase 1 family, member A12002
nuclear receptor subfamily 1, group I, member 33003
pregnane X nuclear receptor4004
caspase-32002
aryl hydrocarbon receptor3003
cytochrome P450 2D6 isoform 12002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
chromobox protein homolog 12002
ras-related protein Rab-9A2002
M-phase phosphoprotein 83003
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0202
Cytochrome P450 1A20101
Cholinesterase0202
Cytochrome P450 2C11 0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Acetylcholinesterase0202
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Mu-type opioid receptor0101
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear receptor ROR-gamma2002
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
Canalicular multispecific organic anion transporter 10202
Carboxylic ester hydrolase 0101
Histamine H3 receptor0101
Photosystem I iron-sulfur center 0001
Chain A, CES1 protein0101
Chain A, Ferritin light chain1001
hypoxia-inducible factor 1 alpha subunit1001
SMAD family member 22002
Fumarate hydratase1001
PPM1D protein1001
SMAD family member 32002
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
estrogen receptor 2 (ER beta)1001
progesterone receptor1001
polyprotein1001
67.9K protein1001
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma3003
thyroid stimulating hormone receptor3003
activating transcription factor 62002
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x2002
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a1001
interferon gamma precursor0001
transcriptional regulator ERG isoform 31001
caspase-31001
serine/threonine-protein kinase mTOR isoform 11001
streptokinase A precursor0011
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
Voltage-dependent calcium channel gamma-2 subunit1001
Serine/threonine-protein kinase D30101
Lysosomal acid glucosylceramidase0011
Integrin beta-31001
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Progesterone receptor0101
Procathepsin L0011
ATP-dependent translocase ABCB10213
Integrin alpha-IIb1001
Beta-1 adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
Androgen receptor0202
Protein kinase C alpha type0101
5-hydroxytryptamine receptor 1A0202
Glutamate receptor 22002
Cytochrome P450 2B60101
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
Melanocortin receptor 50202
Mu-type opioid receptor0202
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Protein kinase C iota type0101
Melanocortin receptor 30202
Histamine H2 receptor1001
D(1A) dopamine receptor1001
Spike glycoprotein0011
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Potassium voltage-gated channel subfamily H member 20202
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
ATPase family AAA domain-containing protein 51001
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Cruzipain1001
Luciferase1001
GALC protein1001
DNA polymerase kappa isoform 12002
Sodium- and chloride-dependent taurine transporter0101
Ubiquitin-like modifier activating enzyme 20101
SUMO1 activating enzyme subunit 10101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
hexokinase0101
nuclear factor erythroid 2-related factor 2 isoform 21001
DNA polymerase beta1001
SUMO-conjugating enzyme UBC90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
eukaryotic translation initiation factor 4E isoform 10101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Vif0101
Tat0101
histone acetyltransferase KAT2A isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
Aldo-keto reductase family 1 member B10101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
TAR DNA-binding protein 431001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
DNA polymerase iota isoform a (long)1001
Carbonic anhydrase 120001
Dihydrofolate reductase0202
Plasma kallikrein0001
Alkaline phosphatase, tissue-nonspecific isozyme0101
Carbonic anhydrase 30001
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Substance-P receptor0101
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Tryptophan 2,3-dioxygenase0102
Carbonic anhydrase0001
SLC16A10 protein0001
Uracil nucleotide/cysteinyl leukotriene receptor0101
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Tryprostatin B synthase0001
Carbonic anhydrase0001
Carbonic anhydrase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Phospholipase A-2-activating protein0101
Carbonic anhydrase 5B, mitochondrial0001
Chain A, Arginase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]