Target type: molecularfunction
An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates. [PMID:26312418]
ATP-dependent protein disaggregases are molecular chaperones that play a critical role in maintaining cellular proteostasis by resolving protein aggregates. These aggregates can form due to various factors, including stress conditions, mutations, and aging, and can disrupt cellular function. ATP-dependent protein disaggregases utilize the energy from ATP hydrolysis to unfold and disassemble protein aggregates, thereby restoring the functional state of the proteins. The process involves several steps: First, the disaggregase binds to the aggregate and uses its ATPase activity to generate mechanical force. This force helps to pull apart the aggregated proteins, separating them into individual polypeptide chains. Next, the disaggregase can either refold the unfolded proteins into their native conformations or deliver them to other chaperones for further processing. Some disaggregases, like the Hsp104 family, can even assist in the disaggregation of amyloid fibrils, which are highly stable and often associated with neurodegenerative diseases. The molecular mechanism of disaggregation involves the coordinated action of several domains within the disaggregase molecule. The ATPase domain provides energy for the process, while other domains, like the substrate-binding domain, interact with the aggregated proteins. The disaggregase also interacts with other chaperones and cofactors, forming a complex network that facilitates protein disaggregation and proper protein folding.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Heat shock cognate 71 kDa protein | A heat shock cognate 71 kDa protein that is encoded in the genome of human. [PRO:DAN] | Homo sapiens (human) |
| Heat shock 70 kDa protein 1A | A heat shock 70 kDa protein 1A that is encoded in the genome of human. [PRO:DAN, UniProtKB:P0DMV8] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| adenosine diphosphate | Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. | adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate | fundamental metabolite; human metabolite |
| tubercidin | tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus. Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids. | antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; ribonucleoside | antimetabolite; antineoplastic agent; bacterial metabolite |
| toyocamycin | toyocamycin : An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group. Toyocamycin: 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry. | antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; nitrile; ribonucleoside | antimetabolite; antineoplastic agent; apoptosis inducer; bacterial metabolite |
| nsc 65346 | sangivamycin : A nucleoside analogue that is adenosine in which the nitrogen at position 7 is replaced by a carbamoyl-substituted carbon. It is a potent inhibitor of protein kinase C. sangivamycin: RN given refers to parent cpd | nucleoside analogue | protein kinase inhibitor |
| adenosine | quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | adenosines; purines D-ribonucleoside | analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent |
| 8-aminoadenosine | |||
| 5'-deoxyadenosine | 5'-deoxyadenosine : A 5'-deoxyribonucleoside compound having adenosine as the nucleobase. 5'-deoxyadenosine: main heading DEOXYADENOSINE refers to the 3' cpd | 5'-deoxyribonucleoside; adenosines | Escherichia coli metabolite; human metabolite; mouse metabolite |
| ver 155008 | VER 155008: structure in first source | purine nucleoside | |
| nms-e973 | NMS-E973: structure in first source |