cellular heat acclimation

Definition

Target type: biologicalprocess

Any process that increases heat tolerance of a cell in response to high temperatures. [GOC:jp]

Cellular heat acclimation is a complex physiological adaptation that enables organisms to better tolerate heat stress. It involves a series of molecular and cellular changes that enhance the body's ability to dissipate heat and maintain homeostasis.

The process typically begins with an initial period of heat exposure, which triggers a cascade of cellular responses. These responses are mediated by various signaling pathways, including heat shock proteins (HSPs), which act as molecular chaperones to protect cells from damage.

One of the key adaptations during heat acclimation is an increased expression of heat shock proteins, particularly HSP70, which plays a crucial role in protein folding and stability. Increased HSP70 expression enhances the cell's ability to withstand stress and prevent protein aggregation.

Another important adaptation is an increase in the production of heat shock transcription factors (HSFs). These factors regulate the expression of genes involved in the heat stress response, including HSPs.

Furthermore, heat acclimation can lead to changes in cellular metabolism, such as an increase in glucose uptake and utilization, which provides energy for cellular processes.

At the cellular level, heat acclimation can also induce changes in membrane fluidity and permeability, which can affect cellular signaling and transport processes.

Overall, cellular heat acclimation is a multifaceted process that involves a coordinated response at multiple levels, from molecular to cellular and organismal. It allows organisms to adapt to elevated temperatures and maintain normal function despite the environmental challenge.'
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Proteins (2)

Compounds (6)