Page last updated: 2024-10-24

cerebellum structural organization

Definition

Target type: biologicalprocess

The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]

The cerebellum is a highly organized structure crucial for motor control, coordination, and learning. Its complex architecture is intricately linked to its functional abilities. Here’s a detailed description of the cerebellum’s structural organization:

**1. Layers:**
* **Molecular Layer:** The outermost layer, primarily composed of dendrites of Purkinje cells, axons of granule cells (parallel fibers), and interneurons like stellate and basket cells. This layer facilitates complex synaptic interactions for fine-tuning motor commands.
* **Purkinje Cell Layer:** A single layer of large Purkinje neurons, arranged in a highly organized pattern. Purkinje cells receive input from granule cells and mossy fibers, and their output projects to deep cerebellar nuclei, playing a vital role in motor control.
* **Granule Cell Layer:** The densest layer, packed with small granule cells that receive input from mossy fibers. Their axons, called parallel fibers, run parallel to the Purkinje cell layer and provide the main excitatory input to Purkinje cells.

**2. Anatomical Divisions:**
* **Vermis:** The central, midline portion of the cerebellum, responsible for regulating posture, balance, and axial movements.
* **Hemispheres:** The lateral portions, responsible for coordinating limb movements and fine motor control.
* **Lobules:** Both vermis and hemispheres are subdivided into numerous lobules, each contributing to specific motor functions.
* **Folia:** The cerebellar surface is characterized by numerous parallel folds called folia, increasing the surface area for neuronal connections.

**3. White Matter:**
* **Arbor Vitae:** The white matter located beneath the cerebellar cortex, containing axons connecting different cerebellar regions and transmitting signals to and from other brain areas.

**4. Deep Cerebellar Nuclei:**
* **Dentate Nucleus:** Located laterally, receives input from the cerebellar hemispheres and projects to the thalamus, influencing motor planning and execution.
* **Interposed Nuclei:** Located medially, receive input from the vermis and project to the thalamus and brainstem, contributing to balance and posture control.
* **Fastigial Nucleus:** Located medially, receives input from the vermis and projects to the vestibular nuclei and reticular formation, playing a role in balance and eye movements.

**5. Afferent Inputs:**
* **Mossy Fibers:** Arise from various brain regions, including the pontine nuclei, spinal cord, and vestibular system, carrying sensory and motor information.
* **Climbing Fibers:** Originate from the inferior olivary nucleus, carrying highly specific signals that regulate Purkinje cell activity and contribute to motor learning.

**6. Efferent Outputs:**
* **Purkinje Cells:** Their axons project to deep cerebellar nuclei, mediating the output of the cerebellum.
* **Deep Cerebellar Nuclei:** Project to various brain regions, including the thalamus, brainstem, and spinal cord, influencing motor commands and movement coordination.

**Conclusion:** This complex interplay of different neuronal populations and intricate structural organization underlies the cerebellum’s remarkable ability to coordinate movement, maintain balance, and learn new motor skills. Its precise architecture ensures the smooth execution of voluntary movements and the adaptation of motor patterns in response to changing conditions.'
"

Proteins (1)

ProteinDefinitionTaxonomy
Endoplasmic reticulum chaperone BiPAn endoplasmic reticulum chaperone BiP that is encoded in the genome of human. [PRO:DAN]Homo sapiens (human)

Compounds (10)

CompoundDefinitionClassesRoles
dichlorophenDichlorophen: Nontoxic laxative vermicide effective for taenia infestation. It tends to produce colic and nausea. It is also used as a veterinary fungicide, anthelmintic, and antiprotozoan. (From Merck, 11th ed.)bridged diphenyl fungicide;
diarylmethane
hexachlorophenehexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.

Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
bridged diphenyl fungicide;
polyphenol;
trichlorobenzene
acaricide;
antibacterial agent;
antifungal agrochemical;
antiseptic drug
triclosanaromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols
antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
adenosine diphosphateAdenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate
fundamental metabolite;
human metabolite
2,2'-methylenebis(ethyl-6-tert-butylphenol)
2,2'-methylenebis(4-methyl-6-tert-butylphenol)diarylmethane
oxyclozanideOxyclozanide: Anthelmintic used in grazing animals for fasciola and cestode infestations.
2,2'-bisphenol f2,2'-bisphenol F: contact allergen; structure given in first sourcediarylmethane
8-aminoadenosine
ver 155008VER 155008: structure in first sourcepurine nucleoside