positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway. [GOC:add]

Positive regulation of NOD2 signaling pathway is a crucial process in innate immunity, mediating the host's response to bacterial pathogens. NOD2, a cytoplasmic pattern recognition receptor, recognizes muramyl dipeptide (MDP), a peptidoglycan component found in bacterial cell walls. Upon MDP binding, NOD2 undergoes a conformational change, leading to the formation of a protein complex that activates downstream signaling cascades. This complex includes proteins such as receptor-interacting protein kinase 2 (RIP2), which acts as an adaptor molecule, and the transcription factor NF-κB. The activation of RIP2 by NOD2 triggers a series of phosphorylation events that ultimately lead to the activation of NF-κB. Activated NF-κB translocates to the nucleus, where it promotes the transcription of genes involved in the inflammatory response, such as pro-inflammatory cytokines, chemokines, and antimicrobial peptides. These molecules contribute to the recruitment of immune cells to the site of infection and the clearance of pathogens. The positive regulation of NOD2 signaling pathway is essential for the host's defense against bacterial infections. Dysregulation of this pathway has been implicated in the pathogenesis of inflammatory bowel diseases (IBDs) such as Crohn's disease.'
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Proteins (2)

Compounds (9)