Target type: molecularfunction
A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification. [PMID:10652346]
Transcription regulator inhibitor activity describes the ability of a molecule to block or reduce the activity of a transcription regulator. Transcription regulators are proteins that bind to DNA and control the expression of genes. They can act as activators, increasing the rate of transcription, or as repressors, decreasing the rate of transcription. Transcription regulator inhibitors can work by a variety of mechanisms, including:
- Binding to the transcription regulator and preventing it from binding to DNA.
- Binding to the DNA binding site of the transcription regulator and blocking its access to the DNA.
- Interfering with the interaction between the transcription regulator and other proteins that are required for its activity.
- Altering the structure of the transcription regulator, making it inactive.
Transcription regulator inhibitors are important for a variety of biological processes, including:
- Regulation of gene expression
- Cell growth and development
- Response to stress
- Immune response
Inhibitors of transcription regulators are also being investigated as potential therapeutic agents for a variety of diseases, including cancer, inflammation, and infection.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Nuclear receptor subfamily 0 group B member 2 | A nuclear receptor subfamily 0 group B member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15466] | Homo sapiens (human) |
| NF-kappa-B inhibitor alpha | An NF-kappa-B inhibitor alpha that is encoded in the genome of human. [TLR:AMM, UniProtKB:P25963] | Homo sapiens (human) |
| Transcription initiation factor TFIID subunit 1 | A transcription initiation factor TFIID subunit 1 that is encoded in the genome of human. [PRO:DNx] | Homo sapiens (human) |
| Heat shock 70 kDa protein 1A | A heat shock 70 kDa protein 1A that is encoded in the genome of human. [PRO:DAN, UniProtKB:P0DMV8] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| adenosine diphosphate | Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. | adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate | fundamental metabolite; human metabolite |
| adenosine | quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | adenosines; purines D-ribonucleoside | analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent |
| 8-aminoadenosine | |||
| 8-(4-benzenesulfonylamino)quinoline | 8-(4-benzenesulfonylamino)quinoline: has diabetogenic properties; structure given in first source | ||
| benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative. | amino aldehyde; carbamate ester; tripeptide | proteasome inhibitor |
| 5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxide | benzothiazine | ||
| 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid | |||
| bi 2536 | |||
| nsc-287088 | |||
| ver 155008 | VER 155008: structure in first source | purine nucleoside | |
| physalin a | physalin A: an anti-inflammatory agent isolated from Physalis alkekengi var; structure in first source | physalin | |
| (3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)-4-pyrimidinyl]-3-methylmorpholine | indoles | ||
| physalin f | physalin F : A physalin with antimalarial and antitumour activities isolated from Physalis angulata. physalin F: has immunosuppressive activity; from Physalis angulata L; structure given in first source | enone; epoxy steroid; lactone; physalin | antileishmanial agent; antimalarial; antineoplastic agent; apoptosis inducer; immunosuppressive agent |
| i-bet726 |