Target type: biologicalprocess
The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
The cerebellar Purkinje cell layer undergoes a complex and precisely regulated developmental process that involves a series of intricate steps. This process begins with the migration of Purkinje cell precursors from the external granular layer (EGL) to their final position in the internal granular layer (IGL). This migration is guided by a variety of cues, including radial glial fibers and chemoattractants. Once Purkinje cells reach their final position, they begin to differentiate and mature. This process involves the expression of specific genes that control the formation of dendrites, axons, and synapses. Purkinje cells also begin to express specific neurotransmitters and receptors that allow them to communicate with other neurons in the cerebellum. The development of the Purkinje cell layer is tightly regulated by a variety of signaling pathways, including Wnt, Shh, and BMP signaling. These pathways play a critical role in controlling the proliferation, differentiation, and migration of Purkinje cells. The development of the Purkinje cell layer is essential for the proper function of the cerebellum. The cerebellum plays a crucial role in motor control, coordination, and learning. Disruptions in Purkinje cell layer development can lead to a variety of neurological disorders, including ataxia, dysmetria, and tremor.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Endoplasmic reticulum chaperone BiP | An endoplasmic reticulum chaperone BiP that is encoded in the genome of human. [PRO:DAN] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| dichlorophen | Dichlorophen: Nontoxic laxative vermicide effective for taenia infestation. It tends to produce colic and nausea. It is also used as a veterinary fungicide, anthelmintic, and antiprotozoan. (From Merck, 11th ed.) | bridged diphenyl fungicide; diarylmethane | |
| hexachlorophene | hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797) | bridged diphenyl fungicide; polyphenol; trichlorobenzene | acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug |
| triclosan | aromatic ether; dichlorobenzene; monochlorobenzenes; phenols | antibacterial agent; antimalarial; drug allergen; EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; fungicide; persistent organic pollutant; xenobiotic | |
| adenosine diphosphate | Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. | adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate | fundamental metabolite; human metabolite |
| 2,2'-methylenebis(ethyl-6-tert-butylphenol) | |||
| 2,2'-methylenebis(4-methyl-6-tert-butylphenol) | diarylmethane | ||
| oxyclozanide | Oxyclozanide: Anthelmintic used in grazing animals for fasciola and cestode infestations. | ||
| 2,2'-bisphenol f | 2,2'-bisphenol F: contact allergen; structure given in first source | diarylmethane | |
| 8-aminoadenosine | |||
| ver 155008 | VER 155008: structure in first source | purine nucleoside |