lead-radioisotopes and 1-4-7-10-tetraazacyclododecane-1-4-7-10-tetrakis(methylenephosphonic-acid)

lead-radioisotopes has been researched along with 1-4-7-10-tetraazacyclododecane-1-4-7-10-tetrakis(methylenephosphonic-acid)* in 1 studies

Other Studies

1 other study(ies) available for lead-radioisotopes and 1-4-7-10-tetraazacyclododecane-1-4-7-10-tetrakis(methylenephosphonic-acid)

ArticleYear
212Bi-DOTMP: an alpha particle emitting bone-seeking agent for targeted radiotherapy.
    Nuclear medicine and biology, 1997, Volume: 24, Issue:3

    The synthesis and in vivo stability of the bone-seeking alpha-particle emitting compounds 212Bi-DOTMP and 212Pb/212Bi-DOTMP are described. 212Bi-DOTMP, injected i.v. into Balb/c mice, showed prominent bone localization and a rapid clearance from blood and other organs. Femur/blood ratios increased from 13 at 15 min up to 490 at 2.0 h postinjection. Enhanced uptake of 212Bi-DOTMP was demonstrated in regions with high bone turnover. A comparison between 212Bi-DOTMP and [153Sm]Sm-EDTMP showed essentially no differences in biodistribution. 212Pb/212Bi-DOTMP followed a similar biodistribution, except for slightly elevated levels of 212Bi in the kidneys. The present study has shown 212Bi-DOTMP to be an in vivo stable bone-seeking radiopharmaceutical with promising biological properties for the treatment of sclerotic metastases and osteoblastic osteosarcoma.

    Topics: Alpha Particles; Animals; Bismuth; Bone and Bones; Drug Stability; Female; Femur; Lead Radioisotopes; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Organophosphorus Compounds; Radioisotopes; Radiopharmaceuticals; Tissue Distribution

1997