Page last updated: 2024-11-13

monazite

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

monazite: mineral (rare earth phosphate) found in heavy dark brown sand along coastal tracts of India [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
India	genus	A country in southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan. The capitol is New Delhi.[MeSH]	Orchidaceae	A plant family of the order Asparagales. All members of the orchid family have the same bilaterally symmetrical flower structure, with three sepals, but the flowers vary greatly in color and shape.[MeSH]

Cross-References

ID Source	ID
PubMed CID	86278150
MeSH ID	M0064565

Synonyms (8)

Synonym
monazite
unii-5ihu10ggzu
5ihu10ggzu ,
1306-41-8
monazite-(ce) ((ce0.5-1la0-0.5nd0-0.5th0-0.5)(po4))
monazite-ce
Q27262338
cerium(3+);lanthanum(3+);neodymium(3+);oxygen(2-);phosphate

Research Excerpts

Overview

Monazite is a phosphate mineral containing the rare earth elements (REE) cerium, lanthanum and neodymium. It is processed for use in a variety of domestic applications.

Excerpt	Reference	Relevance
"Monazite is a naturally occurring lanthanide (Ln) phosphate mineral [Ln "	( Monazite transformation into Ce- and La-containing oxalates by Aspergillus niger. Csetenyi, L; Gadd, GM; Kang, X, 2020)	3.44
"Monazite is a phosphate mineral containing the rare earth elements (REE) cerium, lanthanum and neodymium."	( Colonization and bioweathering of monazite by Aspergillus niger: solubilization and precipitation of rare earth elements. Csetenyi, L; Gadd, GM; Kang, X, 2021)	1.62
"Monazite is a naturally occurring radioactive material that is processed for use in a variety of domestic applications. "	( Investigation of Natural Radioactivity in a Monazite Processing Plant in Japan. Hosoda, M; Iwaoka, K; Kanda, R; Suzuki, T; Tokonami, S; Yajima, K; Yonehara, H, 2017)	2.16

Toxicity

Workers employed on mining, processing and storage of monazite are at risk of exposure to dust with expected adverse health effects. To test the possibility of attenuating these effects.

Excerpt	Reference	Relevance
"Workers employed on mining, processing and storage of monazite are at risk of exposure to dust with expected adverse health effects."	( Toxicity of monazite particulates and its attenuation with a complex of bio-protectors. Beresneva, OY; Bukhantsev, VA; Degtyareva, TD; Dovzenko, EI; Katsnelson, BA; Kireyeva, EP; Kostykova, SV; Kulikov, ES; Makeyev, OH; Minihaliyeva, IA; Minin, VV; Nazukin, AS; Privalova, LI; Sutunkova, MP; Valamina, IE; Yeremenko, OS, )	0.76
"To study the adverse health effects of monazite particles in experiments on rats and to test the possibility of attenuating these effects."	( Toxicity of monazite particulates and its attenuation with a complex of bio-protectors. Beresneva, OY; Bukhantsev, VA; Degtyareva, TD; Dovzenko, EI; Katsnelson, BA; Kireyeva, EP; Kostykova, SV; Kulikov, ES; Makeyev, OH; Minihaliyeva, IA; Minin, VV; Nazukin, AS; Privalova, LI; Sutunkova, MP; Valamina, IE; Yeremenko, OS, )	0.78
"It may be assumed that the many-sided adverse effects of MC on the organism is due, at least partially, to the presence in its composition of not only rare earth elements but also of natural radioisotopes of the thorium and uranium families."	( Toxicity of monazite particulates and its attenuation with a complex of bio-protectors. Beresneva, OY; Bukhantsev, VA; Degtyareva, TD; Dovzenko, EI; Katsnelson, BA; Kireyeva, EP; Kostykova, SV; Kulikov, ES; Makeyev, OH; Minihaliyeva, IA; Minin, VV; Nazukin, AS; Privalova, LI; Sutunkova, MP; Valamina, IE; Yeremenko, OS, )	0.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (51)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (7.84)	18.7374
1990's	7 (13.73)	18.2507
2000's	7 (13.73)	29.6817
2010's	20 (39.22)	24.3611
2020's	13 (25.49)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 71.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	71.13 (24.57)
Research Supply Index	3.97 (2.92)
Research Growth Index	5.06 (4.65)
Search Engine Demand Index	118.61 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (71.13)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (1.92%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	51 (98.08%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
oxalic acid Oxalic Acid: A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.. oxalic acid : An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.	2.31	1	alpha,omega-dicarboxylic acid	algal metabolite; human metabolite; plant metabolite
selenic acid Selenic Acid: A strong dibasic acid with the molecular formula H2SeO4. Included under this heading is the acid form, and inorganic salts of dihydrogen selenium tetraoxide.	2.11	1	selenium oxoacid
phencyclidine Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.	3.07	5	benzenes; piperidines	anaesthetic; neurotoxin; NMDA receptor antagonist; psychotropic drug
siderite ferrous carbonate : A carbonate salt in which the counter-ion is iron in the +2 oxidation state.	2.17	1	carbonate mineral; carbonate salt; iron molecular entity; one-carbon compound
strontium carbonate [no description available]	2.17	1
carbonates Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed). carbonates : Organooxygen compounds that are salts or esters of carbonic acid, H2CO3.	2.17	1	carbon oxoanion
lanthanum [no description available]	2.69	2	f-block element atom; lanthanoid atom; scandium group element atom
thorium Thorium: A radioactive element of the actinide series of metals. It has an atomic symbol Th, atomic number 90, and atomic weight 232.04. It is used as fuel in nuclear reactors to produce fissionable uranium isotopes. Because of its radioopacity, various thorium compounds are used to facilitate visualization in roentgenography.	8.92	12	actinoid atom; f-block element atom
cerium Cerium: An element of the rare earth family of metals. It has the atomic symbol Ce, atomic number 58, and atomic weight 140.12. Cerium is a malleable metal used in industrial applications.	7.46	2	f-block element atom; lanthanoid atom
uranium Uranium: A radioactive element of the actinide series of metals. It has an atomic symbol U, atomic number 92, and atomic weight 238.03. U-235 is used as the fissionable fuel in nuclear weapons and as fuel in nuclear power reactors.	8.53	7	actinoid atom; f-block element atom; monoatomic uranium
zirconium Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.	2.01	1	titanium group element atom
lead chromate lead chromate: RN given refers to unspecified lead chromate. lead chromate : A chromium coordination entity comprising chromate and lead(2+) ions in a 1:1 ratio	2.11	1	chromium coordination entity; lead coordination entity	carcinogenic agent; nephrotoxin; neurotoxin
chromates Chromates: Salts of chromic acid containing the CrO(2-)4 radical.. chromate(2-) : A chromium oxoanion resulting from the removal of two protons from chromic acid.	2.11	1	chromium oxoanion; divalent inorganic anion	oxidising agent
strontium chromate [no description available]	2.11	1
radon Radon: A naturally radioactive element with atomic symbol Rn, and atomic number 86. It is a member of the noble gas family found in soil, and is released during the decay of RADIUM.. radon(0) : A monoatomic radon that has an oxidation state of zero.	8.19	5	monoatomic radon; noble gas atom; p-block element atom
zircon zircon: RN given refers to Zr(+4)[1:1] salt; structure	2.01	1
metaphosphoric acid metaphosphoric acid: RN given refers to cpd with structure HPO3. phosphonate(1-) : A monovalent inorganic anion obtained by deprotonation of one of the two OH groups in phosphonic acid.	2.01	1
lead Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.	2.11	1	carbon group element atom; elemental lead; metal atom	neurotoxin
strontium Strontium: An element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.	2.54	2	alkaline earth metal atom
germanium Germanium: A rare metal element with a blue-gray appearance and atomic symbol Ge, atomic number 32, and atomic weight 72.63.	2.06	1	carbon group element atom; metalloid atom; nonmetal atom
radium Radium: A radioactive element of the alkaline earth series of metals. It has the atomic symbol Ra and atomic number 88. Radium is the product of the disintegration of URANIUM and is present in pitchblende and all ores containing uranium. It is used clinically as a source of beta and gamma-rays in radiotherapy, particularly BRACHYTHERAPY.	2.97	4	alkaline earth metal atom
oxalates Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.	7.25	1
chitosan [no description available]	3.01	2
lead radioisotopes Lead Radioisotopes: Unstable isotopes of lead that decay or disintegrate emitting radiation. Pb atoms with atomic weights 194-203, 205, and 209-214 are radioactive lead isotopes.	2.69	3

Condition	Relationship Strength	Studies
Harelip [description not available]	2.07	1
Cleft Palate, Isolated [description not available]	2.07	1
Deficiency, Mental [description not available]	2.07	1
Injuries, Radiation [description not available]	2.07	1
Cleft Lip Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.	7.07	1
Cleft Palate Congenital fissure of the soft and/or hard palate, due to faulty fusion.	2.07	1
Intellectual Disability Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)	2.07	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.07	1
Bagassosis A diffuse parenchymal lung disease caused by inhaled dust from processing SUGARCANE (bagasse), usually in the manufacturing of wallboard.	1.93	1
Pneumoconiosis A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.	1.93	1
Allergic Reaction [description not available]	1.96	1
Rheumatism [description not available]	6.96	1
Dermatoses [description not available]	1.96	1
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	1.96	1
Rheumatic Diseases Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.	1.96	1
Skin Diseases Diseases involving the DERMIS or EPIDERMIS.	1.96	1
Endomyocardial Fibrosis A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).	1.99	1

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