Genital Infantilism

The permanent lack of SEXUAL DEVELOPMENT in an individual. This defect is usually observed at an age after expected PUBERTY.

Synonym
Infantilism, Genital
Sexual Infantilism
Infantilism, Sexual
Genital Infantilism

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	24 (77.42)	23.3326
1990's	0 (0.00)	12.5806
2000's	3 (9.68)	18.1394
2010's	3 (9.68)	28.8240
2020's	1 (3.23)	9.53

Drug	Relationship Strength	Studies
iodine	low	1
metyrapone	low	1
aminosalicylic acid	low	1
prednisolone	low	2
estriol	low	1
thyroxine	low	1
estrone	low	1
dehydroepiandrosterone	low	1
serine	low	1
cyanides	low	1
ethinyl estradiol	low	1
testosterone propionate	low	1
methyltestosterone	low	3
17-alpha-hydroxyprogesterone	low	1
fluoxymesterone	low	3
succinonitrile	low	1
streptomycin	low	1
cortisone	low	2
glycogen	low	2
diethylstilbestrol	low	1
lithium	low	1
17-ketosteroids	low	2
lead	low	1
pregnanediol	low	2
sodium ethylxanthate	low	3
tetracycline	low	1
folic acid	low	1

Protein Targets (395)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
acetylcholinesterase	3	0	0	3
pregnane X receptor	6	0	0	6
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
TDP1 protein	10	0	0	10
GLI family zinc finger 3	14	0	0	14
Microtubule-associated protein tau	4	0	0	4
AR protein	13	0	0	13
progesterone receptor	13	0	0	13
glucocorticoid receptor [Homo sapiens]	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
retinoid X nuclear receptor alpha	13	0	0	13
estrogen-related nuclear receptor alpha	13	0	0	13
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	13	0	0	13
estrogen nuclear receptor alpha	14	0	0	14
G	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
activating transcription factor 6	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
chromobox protein homolog 1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
geminin	7	0	0	7
survival motor neuron protein isoform d	3	0	0	3
histone acetyltransferase KAT2A isoform 1	1	0	0	1
lamin isoform A-delta10	7	0	0	7
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Glucocorticoid receptor	0	14	1	20
Sex hormone-binding globulin	0	0	7	7
Glycine receptor subunit alpha-1	0	14	0	14
Corticosteroid-binding globulin	0	6	0	6
Adenosine receptor A3	0	6	0	6
Replicase polyprotein 1ab	0	1	0	1
Androgen receptor	0	12	0	12
Alpha-1B adrenergic receptor	0	7	0	7
Glutamate receptor 2	8	0	0	8
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	7	0	7
Sodium-dependent dopamine transporter	0	6	0	6
TAR DNA-binding protein 43	8	0	0	8
Inositol hexakisphosphate kinase 1	6	0	0	6
cytochrome P450 2C9, partial	6	0	0	6
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
thioredoxin glutathione reductase	1	0	0	1
Smad3	3	0	0	3
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	0	4
Tyrosine-protein phosphatase non-receptor type 1	0	0	1	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
endonuclease IV	2	0	0	2
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	4	0	0	4
RAR-related orphan receptor gamma	12	0	0	12
GLS protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
regulator of G-protein signaling 4	2	0	0	2
peroxisome proliferator-activated receptor delta	7	0	0	7
peroxisome proliferator activated receptor gamma	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
peripheral myelin protein 22 isoform 1	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
heat shock protein beta-1	6	0	0	6
flap endonuclease 1	1	0	0	1
cytochrome P450 3A4 isoform 1	6	0	0	6
M-phase phosphoprotein 8	1	0	0	1
muscarinic acetylcholine receptor M1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	6	0	0	6
Bile salt export pump	0	9	0	9
Gamma-aminobutyric acid receptor subunit beta-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit delta	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-2	6	0	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
GABA theta subunit	6	0	0	6
Multidrug and toxin extrusion protein 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	6	0	0	6
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
estrogen receptor 2 (ER beta)	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
cytochrome P450 2D6	3	0	0	3
aryl hydrocarbon receptor	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
thyroid hormone receptor beta isoform 2	9	0	0	9
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Alpha-synuclein	3	3	0	6
G-protein coupled bile acid receptor 1	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
Luciferase	4	0	0	4
interleukin 8	2	0	0	2
glp-1 receptor, partial	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
ATAD5 protein, partial	2	0	0	2
USP1 protein, partial	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
67.9K protein	2	0	0	2
IDH1	2	0	0	2
Histone H2A.x	4	0	0	4
cellular tumor antigen p53 isoform a	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
thyroid hormone receptor beta isoform a	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
peripheral myelin protein 22	2	0	0	2
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lethal factor (plasmid)	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	1	1	2
Estrogen receptor	0	10	3	14
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Cellular tumor antigen p53	7	0	0	7
Integrin beta-3	1	0	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Integrin alpha-IIb	1	0	0	1
Beta-1 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
D(2) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	0	4
Thromboxane-A synthase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Adenosine receptor A2a	0	4	0	4
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	8	0	8
Mu-type opioid receptor	0	4	0	4
D(3) dopamine receptor	0	2	0	2
Vasopressin V1a receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	4	0	4
5-hydroxytryptamine receptor 2B	0	4	0	4
Histamine H2 receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Nuclear receptor ROR-gamma	5	0	0	5
Spike glycoprotein	1	0	0	1
Estrogen-related receptor gamma	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Aldehyde oxidase	0	2	0	2
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Estrogen receptor beta	0	6	3	10
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Cysteinyl leukotriene receptor 1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
NFKB1 protein, partial	1	0	0	1
GALC protein	2	0	0	2
nonstructural protein 1	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
glucokinase regulatory protein	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Rap guanine nucleotide exchange factor 3	2	0	0	2
Steryl-sulfatase	0	1	0	1
Aromatase	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Mu-type opioid receptor	0	0	1	1
Mu-type opioid receptor	0	0	1	1
Cytochrome P450 1B1	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
Fumarate hydratase	1	0	0	1
PPM1D protein	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
polyprotein	1	0	0	1
caspase-3	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Vpr	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	4
Cytochrome P450 2B1	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Cytochrome P450 2B6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	3	0	3
transcriptional regulator ERG isoform 3	2	0	0	2
Androgen receptor	0	5	1	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
acid sphingomyelinase	1	0	0	1
glucocerebrosidase	2	0	0	2
alpha-galactosidase	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
DNA polymerase beta	1	0	0	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Cytochrome P450 2C9	0	1	0	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
phosphopantetheinyl transferase	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Cholinesterase	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Bile salt export pump	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
Androgen receptor	0	0	1	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Neuropeptide FF receptor 2	0	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
EWS/FLI fusion protein	2	0	0	2
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research

Studies (31)

Protein Targets (395)

Genital Infantilism

Synonyms(4)

Research

Studies (31)

Drugs Studied (36)

Protein Targets (395)