Compounds > cp 113818
Page last updated: 2024-12-08

cp 113818

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

CP 113818: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID164373
CHEMBL ID25045
SCHEMBL ID8321431
MeSH IDM0230830

Synonyms (19)

Synonym
(s)-2-hexylsulfanyl-decanoic acid (6-methyl-2,4-bis-methylsulfanyl-pyridin-3-yl)-amide
bdbm50041289
cp 113818
CHEMBL25045 ,
n-(2,4-bis(methylthio)-6-methylpyridin-3-yl)-2-(hexylthio)decanoic acid amide
decanamide, 2-(hexylthio)-n-(6-(methyl-2,4-bis(methylthio)-3-pyridinyl)-, (s)-
135025-12-6
(2s)-2-hexylsulfanyl-n-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]decanamide
cp 113,818
cp-113,818
cp-113818
SCHEMBL8321431
HY-105445
(s)-2-(hexylthio)-n-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)decanamide
2-(hexylsulfanyl)-n-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]decanimidic acid
DTXSID10928862
GLXC-26605
CS-0026013
PD128513

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Addition of an intracellular cholesterol transport inhibitor, either progesterone or U18666A, together with CP-113,818 blocked the toxic effect of CP-113,818."( Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol.
Bamberger, M; Johnson, WJ; Rothblat, GH; Stoudt, G; Warner, GJ, 1995)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID51771Dose required for 50 percent inhibition of rat Pancreatic cholesterol esterase in vitro No effect at 300 uM1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
AID99720Dose required for 50 percent inhibition of lecithin cholesterol acyl transferase in vitro in rats at 300 uM; No effect1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
AID155223Dose required for 50 percent inhibition of Pancreatic lipase in vitro from rats at 300 uM1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
AID178382Effective dose for 50 percent removal in rats1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
AID166660Evaluation for the plasma cholesterol lowering in rabbits at the dose 5 mg/kg1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
AID31384Dose required for 50 percent inhibition of Acyl coenzyme A:cholesterol acyltransferase in vitro in rats at 0.022 uM1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
AID83817Effects on cholesterol absorption in hamsters1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
AID31375In vitro potency was determined using Acyl coenzyme A:cholesterol acyltransferase in liver microsomes from rats1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
AID81007Dose required for 50 percent inhibition of 3-Hydroxy-3-methylglutaryl coenzyme A reductase in vitro in rats;Not determined1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
AID157528Dose required for 50 percent inhibition of Pancreatic cholesterol esterase in vitro in rats at 300 uM; No effect1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (58.33)18.2507
2000's4 (33.33)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.73 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		1.98106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
carbamates
[no description available]		1.9810amino-acid anion
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.4620benzenes;
phenyl acetates
25-hydroxycholesterol
[no description available]		1.991025-hydroxy steroid;
oxysterol		human metabolite
pd 128042
PD 128042: structure given in first source		2.3920anilide
cl 277082
CL 277082: structure given in first source		1.9910
avasimibe
[no description available]		2.4620monoterpenoid
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.		1.99103,5-dihydroxy-3-methylpentanoic acid
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		2.3920octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester
((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester: a water soluble inhibitor of ACAT; structure in first source		1.9810
u 18666a
3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one: inhibits cycloartenol synthase. 3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride : A hydrochloride obtained by reaction of 3beta-(2-diethylaminoethoxy)androst-5-en-17-one with one equivalent of hydrochloric acid. It is a cholesterol synthesis and transport inhibitor.		210hydrochlorideantiviral agent;
EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor;
Hedgehog signaling pathway inhibitor;
nicotinic antagonist;
sterol biosynthesis inhibitor
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.98101,2-diacyl-sn-glycero-3-phosphocholine
amyloid beta-peptides
amyloid beta-protein (1-40): although acutely neurotoxic in both rat & monkey cerebral cortex, neuronal degeneration in primates resembles more closely to that found in Alzheimer's disease; amino acid sequence has been determined		2.0510
filipin
Filipin: A complex of polyene antibiotics obtained from Streptomyces filipinensis. Filipin III alters membrane function by interfering with membrane sterols, inhibits mitochondrial respiration, and is proposed as an antifungal agent. Filipins I, II, and IV are less important.		210
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Confusional Senile Dementia
[description not available]		02.4420
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.4420
Astrocytosis
[description not available]		02.0510
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		02.0510
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.4420
Amyloid Deposits
[description not available]		02.0210