Compounds > lecimibide
Page last updated: 2024-11-06

lecimibide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID71355
CHEMBL ID274185
SCHEMBL ID49619
MeSH IDM0223505

Synonyms (31)

Synonym
lecimibide
3-(2,4-difluoro-phenyl)-1-[5-(4,5-diphenyl-1h-imidazol-2-ylsulfanyl)-pentyl]-1-heptyl-urea
bdbm50033969
D03735
lecimibide (usan)
130804-35-2
dup 128
CHEMBL274185 ,
dup-128
3-(2,4-difluorophenyl)-1-[5-[(4,5-diphenyl-1h-imidazol-2-yl)sulfanyl]pentyl]-1-heptylurea
unii-a7t248b302
3-(2,4-difluorophenyl)-1-(5-((4,5-diphenylimidazol-2-yl)thio)pentyl)-1-heptylurea
a7t248b302 ,
urea, n'-(2,4-difluorophenyl)-n-(5-((4,5-diphenyl-1h-imidazol-2-yl)thio)pentyl)-n-heptyl-
lecimibide [usan:inn]
3-(2,4-difluorophenyl)-1-[5-[(4,5-diphenylimidazol-2-yl)thio]pentyl]-1-heptylurea
lecimibide [inn]
lecimibide [usan]
lecimibide [who-dd]
SCHEMBL49619
n'-(2,4-difluorophenyl)-n-[5-(4,5 -diphenyl-1h-imidazol-2-ylthio)pentyl]-n-heptylurea
n'-(2,4-difluorophenyl)-n-[5-(4,5-diphenyl-1h-imidazol-2-ylthio)pentyl]-n-heptylurea
TVXOXGBTADZYCZ-UHFFFAOYSA-N
3-(2,4-difluorophenyl)-1-{5-[(4,5-diphenyl-1h-imidazol-2-yl)sulfanyl]pentyl}-1-heptylurea
3-(2,4-difluorophenyl)-1-[5-[[4,5-di(phenyl)-1h-imidazol-2-yl]sulfanyl]pentyl]-1-heptylurea
DTXSID80156751
dup128
Q1303494
3-(2,4-difluorophenyl)-1-(5-((4,5-diphenyl-1h-imidazol-2-yl)thio)pentyl)-1-heptylurea
GLXC-26601
AKOS040747027

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" We evaluated the effect of a potent, poorly absorbed ACAT inhibitor (DuP 128: N'-(2,4-difluorophenyl)-N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pe ntyl]- N-heptylurea) on cholesterol absorption in a randomized trial."( Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans.
Connell, JM; Crouse, JR; Gillies, PJ; Hainer, JW; Hunt, TL; Jenkins, RM; Livak, KJ; Shand, DL; Terry, JG; Zyruk, H, 1994)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (2)

PathwayProteinsCompounds
sterol:steryl ester interconversion (yeast)513
sterol:steryl ester interconversion513

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sterol O-acyltransferase 1Rattus norvegicus (Norway rat)IC50 (µMol)0.28000.00580.66266.0000AID1396706; AID197093; AID31367
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)IC50 (µMol)0.01000.00052.773925.1700AID197093
Sterol O-acyltransferase 1Mus musculus (house mouse)IC50 (µMol)0.91000.06000.59001.0000AID1396700; AID1396706
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (37)

Assay IDTitleYearJournalArticle
AID1396706Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholesterol
AID168869Hypercholesterolemic activity in rats at a dose of 10 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID31364Compound was evaluated for the Acyl coenzyme A:cholesterol acyltransferase inhibition using microsomes isolated from the livers of cholesterol fed rats.1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181768Chronic effect on preestablished dyslipidemia in rats for total cholesterol at 30 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID168868Hypercholesterolemic activity in rats at a dose of 1 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID83670Evaluated for Syrian hamsters fed with 2.5% cholesterol-supplemented chow diet for 3 days1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles.
AID1396700Inhibition of ACAT1 in mouse J774 cells
AID31663Concentration required to inhibit 50% activity of Acyl coenzyme A:cholesterol acyltransferase 1 in vitro using rat liver microsome.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.
AID83816Tested anti-hypercholesterolaemic value(AHV) is the ratio of observed reduction in serum cholesterol to difference between control and baseline levels x100 at 10 mg/kg/day dose1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles.
AID30893Acyl coenzyme A:cholesterol acyltransferase activity was determined in J774 macrophages by measuring the formation of labeled cholesteryl oleate (pmol/midmg) from [14C]oleoyl-CoA1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.
AID1396703Inhibition of SOAT2 in New Zealand white rabbit intestinal microsomes assessed as reduction in cholesteryl oleate formation incubated for 5 mins in presence of [14C]-oleoyl-CoA and BSA complex by TLC method
AID31367In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles.
AID181749Chronic effect on preestablished dyslipidemia in rats for HDL-C at 1 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181760Chronic effect on preestablished dyslipidemia in rats for nonHDL-C at 3 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID83669Evaluated for Syrian hamsters fed with 0.8% cholesterol-supplemented chow diet for 7 days1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles.
AID91773Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.
AID1396701Inhibition of ACAT2 in rat hepatic microsomes
AID181756Chronic effect on preestablished dyslipidemia in rats for nonHDL-C at 10 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID1396702Inhibition of SOAT1 in arterial homogenates isolated from 1% cholesterol fed New Zealand white rabbit assessed as reduction in cholesteryl oleate formation incubated for 5 mins in presence of [14C]-oleoyl-CoA and BSA complex by TLC method
AID181748Chronic effect on preestablished dyslipidemia in rats for HDL-C at 10 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID168873Hypercholesterolemic activity in rats at a dose of 30 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181765Chronic effect on preestablished dyslipidemia in rats for total cholesterol at 10 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181755Chronic effect on preestablished dyslipidemia in rats for nonHDL-C at 100 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID176929Dose required to lower the plasma cholesterol by 50% in rats was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID168871Hypercholesterolemic activity in rats at a dose of 100 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181762Chronic effect on preestablished dyslipidemia in rats for total cholesterol at 1 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181757Chronic effect on preestablished dyslipidemia in rats for nonHDL-C at 1 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181747Chronic effect on preestablished dyslipidemia in rats for HDL-C at 100 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181750Chronic effect on preestablished dyslipidemia in rats for HDL-C at 30 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181751Chronic effect on preestablished dyslipidemia in rats for HDL-C at 3 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181766Chronic effect on preestablished dyslipidemia in rats for total cholesterol at 3 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181764Chronic effect on preestablished dyslipidemia in rats for total cholesterol at 100 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID181759Chronic effect on preestablished dyslipidemia in rats for nonHDL-C at 30 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID168872Hypercholesterolemic activity in rats at a dose of 3 mg/kg of compound was determined1994Journal of medicinal chemistry, Mar-04, Volume: 37, Issue:5
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
AID197093ACAT activity was determined in rat hepatic microsomes by measuring the formation of labeled cholesteryl oleate (pmol/midmg) from [14C]oleoyl-CoA1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.
AID1396704Selectivity ratio of IC50 for inhibition of SOAT2 in New Zealand white rabbit intestinal microsomes to IC50 for inhibition of SOAT1 in arterial homogenates isolated from 1% cholesterol fed New Zealand white rabbit
AID30894Acyl coenzyme A:cholesterol acyltransferase inhibition in cell culture measured in murine IC-21 macrophages.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's10 (71.43)18.2507
2000's3 (21.43)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (7.14%)5.53%
Reviews1 (7.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		1.9810amino-acid anion
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		6.34121isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
taurocholic acid
Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.. taurocholate : An organosulfonate oxoanion that is the conjugate base of taurocholic acid.. taurocholic acid : A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.		1.9810amino sulfonic acid;
bile acid taurine conjugate		human metabolite
chenodeoxycholic acid
Chenodeoxycholic Acid: A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.. chenodeoxycholic acid : A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.. chenodeoxycholate : Conjugate base of chenodeoxycholic acid; major species at pH 7.3.		1.9810bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid		human metabolite;
mouse metabolite
lovastatin
Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.. lovastatin : A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).		1.9810delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug
simvastatin
Simvastatin: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.. simvastatin : A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.		210delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
statin (semi-synthetic)		EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
ferroptosis inducer;
geroprotector;
prodrug
octimibate
[no description available]		2.3920
pd 128042
PD 128042: structure given in first source		4.0140anilide
cl 277082
CL 277082: structure given in first source		2.3920
f 1394
F 1394: an acyl-CoA:cholesterol acyltransferase (ACAT) inibitor; structure given in first source		3.110
ym17e
YM17E: structure given in first source		1.9810
cholic acid
Cholic Acid: A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.. cholic acid : A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.		1.981012alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid		human metabolite;
mouse metabolite
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		3.110
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.		1.98103,5-dihydroxy-3-methylpentanoic acid
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		1.9810octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester
((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester: a water soluble inhibitor of ACAT; structure in first source		1.9810
oleoyl-coenzyme a
oleoyl-coenzyme A: RN given refers to (Z)-isomer		1.9810octadecenoyl-CoAEscherichia coli metabolite;
mouse metabolite
mevalonolactone
mevalonolactone: RN given refers to unlabeled cpd without isomeric designation; structure. mevalonolactone : A racemate comprising equimolar amounts of (R)-mevalonolactone and (S)-mevalonolactone.		1.98104-hydroxy-4-methyloxan-2-onefungal metabolite;
plant metabolite
beta-escin
[no description available]		210
pamaqueside
pamaqueside: structure in first source		210
pd 138142-15
[no description available]		1.9810
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.98101,2-diacyl-sn-glycero-3-phosphocholine
cholestyramine resin
Cholestyramine Resin: A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium Cl(-) anion.		1.9810
tiqueside
tiqueside: reduces intestinal cholesterol absorption with little change in HDL-cholesterol levels & without interfering with enterohepatic bile acid recirculation ; structure given in first source		210
ConditionIndicatedRelationship StrengthStudiesTrials
Elevated Cholesterol
[description not available]		01.9810
Hypercholesterolemia
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.		01.9810
Hyperlipemia
[description not available]		02.9210
Arteriosclerosis
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.		02.9210
Hyperlipidemias
Conditions with excess LIPIDS in the blood.		02.9210