Compounds > circulin b
Page last updated: 2024-11-12

circulin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID10374062
CHEMBL ID4129596
SCHEMBL ID21473999
MeSH IDM0268113

Synonyms (9)

Synonym
circulin b
20905-50-4
3obv7a2jkj ,
unii-3obv7a2jkj
circulin b (bacillus circulans)
l-threonine, (2s)-4-amino-2-((6-methyl-1-oxoheptyl)amino)butanoyl-l-threonyl-(2s)-2,4-diaminobutanoyl-(2s)-2,4-diaminobutanoyl-(2s)-2,4-diaminobutanoyl-d-leucyl-l-isoleucyl-(2s)-2,4-diaminobutanoyl-(2s)-2,4-diaminobutanoyl-, (10->4)-lactam
n.alpha.-(6-methyl-1-oxoheptyl)-l-.alpha.,.gamma.-diaminobutyryl-l-threonyl-l-.alpha.,.gamma.-diaminobutyryl-l-.alpha.,.gamma.-diaminobutyryl-l-.alpha.,.gamma.-diaminobutyryl-d-leucyl-l-isoleucyl-l-.alpha.,.gamma.-diaminobutyryl-l-.alpha.,.gamma.-diaminob
SCHEMBL21473999
CHEMBL4129596
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1494277Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by agar dilution method2018Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1494282Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 18 hrs by agar dilution method2018Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1494280Antibacterial activity against NDM-1 producing Klebsiella pneumoniae ATCC BAA-2146 after 18 hrs by agar dilution method2018Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1494279Antibacterial activity against extended-spectrum beta-lactamase producing Klebsiella pneumoniae 700603 after 18 hrs by agar dilution method2018Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1494278Antibacterial activity against extended-spectrum beta-lactamase producing Escherichia coli isolate 14-11 after 18 hrs by agar dilution method2018Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1494284Acute toxicity in iv dosed ICR mouse assessed as survival measured daily for 7 days2018Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1494281Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by agar dilution method2018Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1494283Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		1.9910sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
oxalic acid
Oxalic Acid: A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.. oxalic acid : An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.		1.9910alpha,omega-dicarboxylic acidalgal metabolite;
human metabolite;
plant metabolite
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		1.9910isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
circulin a
circulin A: a macrocyclic knotted peptide having anti-HIV activity		2.6530
cystine
[no description available]		2.420
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		1.9910cysteiniumfundamental metabolite
oxalates
Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.		1.9910
polymyxin b(1)
[no description available]		2.1710
polymyxin b2
[no description available]		2.1710polymyxin
kalata b1
kalata B1: a 29-residue cyclotide which has a cystine knot structure and beta-sheet; causes uterine contraction; the principal active component from Oldenlandia affinis; amino acid sequence given in first source		2.420
ConditionIndicatedRelationship StrengthStudiesTrials
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		01.9910
Extravascular Hemolysis
[description not available]		0210
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		0210