Deficiency, Hexosediphosphatase

An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Synonym
Fructosediphosphatase Deficiency
Deficiency, Hexosediphosphatase
Fructose-Biphosphatase Deficiency
Fructose-1,6-Bisphosphatase Deficiency
Hexosediphosphatase Deficiency
Fructose-1,6-Diphosphatase Deficiency
Fructose 1,6 Diphosphatase Deficiency

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	31 (48.44)	23.3326
1990's	10 (15.63)	12.5806
2000's	4 (6.25)	18.1394
2010's	11 (17.19)	28.8240
2020's	8 (12.50)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	2	0
citric acid, anhydrous	low	1	0
3-hydroxybutyric acid	low	1	0
methylmalonic acid	low	1	0
lactic acid	low	2	0
dihydroxyacetone	low	1	0
3-phosphoglycerate	low	1	0
glycine	low	1	0
glyceraldehyde	low	1	0
glycerol	low	9	0
alpha-glycerophosphoric acid	low	2	0
hydrogen carbonate	low	3	0
pyruvic acid	low	1	0
thiamine	low	1	0
uric acid	low	4	0
urea	low	1	0
diazoxide	low	1	0
sorbitol	low	2	0
alanine	low	4	0
sucrose	low	1	0
galactose	low	5	0
edetic acid	low	1	0
tyrosine	low	2	0
adenosine monophosphate	low	1	0
methylene blue	low	1	0
leucine	low	2	0
methionine	low	1	0
phenylalanine	low	1	0
histidine	low	1	0
valine	low	1	0
isoleucine	low	1	0
tromethamine	low	1	0
uridine diphosphate galactose	low	1	0
chromium	low	1	0
fructose-1-phosphate	medium	1	1
fructose 2,6-diphosphate	low	1	0
valerates	low	1	0
glycogen	low	4	0
D-fructopyranose	medium	21	1
calcitriol	low	2	0
phosphorus	medium	3	1
phosphocreatine	medium	1	1
cystathionine	low	1	0
glucagon	low	4	0
fructose-1,6-diphosphate	low	2	0
folic acid	low	4	0

Protein Targets (436)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
RAR-related orphan receptor gamma	6	0	0	6
AR protein	8	0	0	8
regulator of G-protein signaling 4	2	0	0	2
glucocorticoid receptor [Homo sapiens]	4	0	0	4
estrogen-related nuclear receptor alpha	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	3
Fructose-1,6-bisphosphatase 1	0	1	0	1
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Cytochrome P450 2C9	0	2	0	3
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Choline O-acetyltransferase	0	1	0	1
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	0	1	1
Adenylate kinase isoenzyme 1	0	1	0	2
P2Y purinoceptor 2	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	1	1	2
P2Y purinoceptor 11	0	0	1	1
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Carbonic anhydrase 1	0	2	0	7
Carbonic anhydrase 2	0	3	1	9
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	1	7
Proton-coupled amino acid transporter 1	0	4	0	5
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, Ferritin light chain	4	0	0	4
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	3	0	0	3
PPM1D protein	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
thioredoxin glutathione reductase	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	2	0	0	2
geminin	5	0	0	5
peripheral myelin protein 22	4	0	0	4
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	3
Bile salt export pump	0	3	0	3
Interferon beta	2	0	0	2
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	0	0	1
Cytochrome P450 3A4	0	2	0	3
Androgen receptor	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
GLI family zinc finger 3	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
farnesoid X nuclear receptor	3	0	0	3
estrogen nuclear receptor alpha	14	0	0	14
peroxisome proliferator activated receptor gamma	2	0	0	2
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	5	0	0	5
perilipin-1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
ATAD5 protein, partial	3	0	0	3
GLS protein	1	0	0	1
TDP1 protein	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lamin isoform A-delta10	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Glutamate receptor 1	0	0	0	2
Glutamate receptor 2	3	0	0	5
Glutamate receptor 3	0	0	0	2
Glutamate receptor 4	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Nicotinamide phosphoribosyltransferase	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
progesterone receptor	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
Histone H2A.x	3	0	0	3
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Cellular tumor antigen p53	6	0	0	6
Amyloid-beta precursor protein	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Histamine H2 receptor	1	0	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
acid sphingomyelinase	1	0	0	1
glp-1 receptor, partial	2	0	0	2
retinoid X nuclear receptor alpha	4	0	0	4
glucocerebrosidase	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
alpha-galactosidase	1	0	0	1
activating transcription factor 6	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
DNA polymerase beta	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	3
Alpha-synuclein	2	0	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
IDH1	2	0	0	2
chromobox protein homolog 1	3	0	0	3
DNA polymerase kappa isoform 1	2	0	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Aldo-keto reductase family 1 member B10	0	0	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
peroxisome proliferator-activated receptor delta	3	0	0	3
thyroid hormone receptor beta isoform 2	3	0	0	3
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	6
Glutamate receptor ionotropic, NMDA 2B	0	2	1	6
Glutamate receptor ionotropic, NMDA 2C	0	2	1	6
Large neutral amino acids transporter small subunit 1	0	8	0	9
Glutamate receptor ionotropic, NMDA 2D	0	2	1	6
Glutamate receptor ionotropic, NMDA 3B	0	2	1	6
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Glutamate receptor ionotropic, NMDA 3A	0	2	1	6
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, Cruzipain	1	0	0	1
Albumin	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
flap endonuclease 1	3	0	0	3
Carbonic anhydrase 12	0	0	0	3
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	0	0	3
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 4	0	1	0	4
Carbonic anhydrase 6	0	1	0	4
Adenosine receptor A1	0	0	0	3
Adenosine receptor A2a	0	0	0	3
Carbonic anhydrase 5A, mitochondrial	0	0	0	3
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase 7	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	1	5
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	2
Carbonic anhydrase 15	0	1	0	4
Carbonic anhydrase 13	0	0	0	2
Carbonic anhydrase 14	0	0	0	3
Carbonic anhydrase 5B, mitochondrial	0	0	0	3
acetylcholinesterase	3	0	0	3
estrogen receptor 2 (ER beta)	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
cytochrome P450 2D6	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Luciferase	3	0	0	3
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
phosphopantetheinyl transferase	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
SMAD family member 2	1	0	0	1
Fumarate hydratase	1	0	0	1
SMAD family member 3	1	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
Smad3	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
pregnane X nuclear receptor	4	0	0	4
G	1	0	0	1
polyprotein	1	0	0	1
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
caspase-3	2	0	0	2
aryl hydrocarbon receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	1	0	0	1
huntingtin isoform 2	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vpr	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
Cruzipain	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Spike glycoprotein	2	0	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Inositol hexakisphosphate kinase 1	1	0	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Zinc finger protein mex-5	0	0	1	1
cytochrome P450 2C9, partial	1	0	0	1
phosphoglycerate kinase	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Serine racemase	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
lethal factor (plasmid)	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Beta-1,4-galactosyltransferase 1	0	0	0	1
N-acetyllactosaminide alpha-1,3-galactosyltransferase	0	0	0	1
P2Y purinoceptor 14	0	0	1	1
Carbonic anhydrase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Deficiency, Hexosediphosphatase

Synonyms(7)

Research

Studies (64)

Protein Targets (436)

Deficiency, Hexosediphosphatase

Synonyms(7)

Research

Studies (64)

Drugs Studied (56)

Protein Targets (436)