Chandler Syndrome

A grouping of three closely linked conditions: iris nevus (or Cogan-Reese) syndrome, Chandler Syndrome, and essential (progressive) iris atrophy. The most common features of this syndrome are the movement of endothelial cells off the cornea onto the iris leading to corneal swelling, distortion of the iris, and variable degrees of distortion of the pupil. The abnormal cell movement plugs fluid outflow channels of the eye causing GLAUCOMA.

Synonym
Iris Atrophy with Corneal Edema and Glaucoma
Iridocorneal Endothelial Syndrome
Chandler's Syndrome
Chandler Syndrome
ICE Syndrome

Excerpt	Reference
"Iridocorneal endothelial syndrome is described to be a rare, usually unilateral ocular condition in young females."	( Azad, N; Islam, F; Khan, A, 2011)
"While the ICE syndrome is known to be associated with glaucoma and bullous keratopathy, to our knowledge, only two cases of ICE syndrome complicated with cystoid macular edema (CME) have been reported to date."	( Horiguchi, M; Mizuguchi, T; Seno, Y; Suzuki, K; Tanikawa, A, 2016)
"Iridocorneal endothelial syndrome is a rare ophthalmic disease, most of which are unilateral and common in women."	( Chen, H; Cheng, SM; Cheng, YY; Xu, HJ; Yin, J, 2022)

Excerpt	Reference
"ICE syndrome has been rarely reported in children."	( Sun, S; Tang, W; Wang, Q; Wu, Z; Zhang, Q; Zhang, Y, 2013)

Excerpt	Reference
"Because the etiology of ICE syndrome is not clear, there is still no effective treatment in clinical practice."	( Li, F; Liu, Y; Sun, Y; Zhang, X, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (6.90)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	20 (68.97)	28.8240
2020's	7 (24.14)	9.53

Drug	Relationship Strength	Studies
acetazolamide	low	1
fluorouracil	low	1
2-propanol	low	13
mitomycin	low	4
edetic acid	low	1
quinoxalines	low	1
sulfur hexafluoride	low	1
timolol	low	1
methotrexate	low	1
nepafenac	low	1
riboflavin	low	1
alpha-chymotrypsin	low	1
brimonidine tartrate	low	1
acyclovir	low	1
eye	low	1

Protein Targets (385)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
RAR-related orphan receptor gamma	6	0	0	6
GLI family zinc finger 3	4	0	0	4
AR protein	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
retinoid X nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	8	0	0	8
peroxisome proliferator-activated receptor delta	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
activating transcription factor 6	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	6	0	0	6
thyroid hormone receptor beta isoform a	3	0	0	3
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
lamin isoform A-delta10	5	0	0	5
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Glutamate receptor 2	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	6	0	0	6
GALC protein	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	4	0	0	4
estrogen-related nuclear receptor alpha	7	0	0	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	4	0	0	4
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
Bloom syndrome protein isoform 1	3	0	0	3
geminin	4	0	0	4
peripheral myelin protein 22	3	0	0	3
survival motor neuron protein isoform d	3	0	0	3
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	2	1	1	4
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	6
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Carbonic anhydrase 12	0	2	1	5
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	5	0	5
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	2	1	7
Carbonic anhydrase 2	0	2	2	7
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	2	1	5
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	1	0	1
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Androgen receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	1	1	4
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	2	1	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	2	1	1	4
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	2	1	4
Carbonic anhydrase 6	0	2	1	4
Gamma-aminobutyric acid receptor subunit gamma-1	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	2	1	1	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	2	1	1	4
Gamma-aminobutyric acid receptor subunit gamma-3	2	1	1	4
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	2	1	1	4
Adenosine receptor A2a	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	1	5
Carbonic anhydrase	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	2	1	4
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	1	1	4
Gamma-aminobutyric acid receptor subunit beta-3	2	1	1	4
Gamma-aminobutyric acid receptor subunit beta-2	2	1	1	4
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	2	1	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	2	1	1	4
Canalicular multispecific organic anion transporter 1	0	5	0	5
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	1	0	2
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	1	1	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	2	1	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	1	5
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	2	0	0	2
Thymidine kinase	0	1	0	1
phosphopantetheinyl transferase	2	0	0	2
GLS protein	1	0	0	1
TDP1 protein	8	0	0	8
Smad3	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
EWS/FLI fusion protein	5	0	0	5
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Solute carrier family 22 member 1	0	0	0	1
Bile salt export pump	0	2	0	2
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2J2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	2
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	2
Thymidine kinase	0	1	0	1
progesterone receptor	5	0	0	5
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Cellular tumor antigen p53	5	0	0	5
Amyloid-beta precursor protein	1	1	0	2
Angiotensin-converting enzyme	0	1	0	1
Histamine H2 receptor	1	0	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	1	0	0	1
interleukin 8	1	0	0	1
endonuclease IV	1	0	0	1
acetylcholinesterase	2	0	0	2
glp-1 receptor, partial	1	0	0	1
Skn7p	0	0	0	1
pregnane X receptor	1	0	0	1
ATAD5 protein, partial	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
Thrombopoietin	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
nonstructural protein 1	1	0	0	1
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	2	0	0	2
67.9K protein	4	0	0	4
peroxisome proliferator activated receptor gamma	4	0	0	4
IDH1	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
chromobox protein homolog 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
thyroid hormone receptor beta isoform 2	3	0	0	3
huntingtin isoform 2	1	0	0	1
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Thymidylate synthase	0	3	0	3
Aromatase	0	1	0	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
USP1 protein, partial	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
vitamin D3 receptor isoform VDRA	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA polymerase kappa isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	2	0	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Integrin alpha-IIb	1	0	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	2	0	0	2
Spike glycoprotein	4	0	0	4
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
Fumarate hydratase	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
cytochrome P450 2D6	3	0	0	3
polyprotein	1	0	0	1
caspase-3	1	0	0	1
aryl hydrocarbon receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
G	1	0	0	1
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
NPYLR7B	0	0	1	1
thyroid stimulating hormone receptor	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
tumor necrosis factor	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
lethal factor (plasmid)	1	0	0	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
NFKB1 protein, partial	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
Beta-1 adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
Beta-2 adrenergic receptor	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (29)

Protein Targets (385)

Chandler Syndrome

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (29)

Drugs Studied (16)

Protein Targets (385)