acetyltransferase activator activity

Definition

Target type: molecularfunction

Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule. [GOC:dph, GOC:jp, GOC:tb, PMID:23912279]

Acetyltransferase activator activity refers to the ability of a molecule to enhance or stimulate the catalytic activity of acetyltransferases. Acetyltransferases are a class of enzymes that catalyze the transfer of an acetyl group (CH3CO) from a donor molecule, typically acetyl-CoA, to an acceptor molecule. This process is known as acetylation, a crucial modification in various cellular processes. Acetyltransferase activators can exert their influence through different mechanisms: 1. **Allosteric regulation:** They bind to the acetyltransferase at a site distinct from the active site, inducing conformational changes that enhance enzyme activity. 2. **Chaperone-like activity:** They assist in the proper folding or assembly of the acetyltransferase, leading to an active conformation. 3. **Increased substrate affinity:** They promote the interaction between the acetyltransferase and its substrate, thereby increasing the reaction rate. 4. **Co-factor modulation:** They may influence the availability or binding of essential cofactors, such as acetyl-CoA, to the enzyme. The impact of acetyltransferase activator activity is diverse and extends to numerous cellular functions, including: **Gene expression regulation:** Acetylation of histones, the proteins that package DNA, influences chromatin structure and accessibility to transcription factors, thereby regulating gene expression. **Protein activity modulation:** Acetylation of non-histone proteins can alter their function, affecting signaling pathways, protein stability, and protein-protein interactions. **Metabolic pathways:** Acetyltransferases play critical roles in metabolic pathways, and their activators can influence the production of various metabolites. **Disease pathogenesis:** Dysregulation of acetyltransferase activity, either through impaired activation or inhibition, has been implicated in the development of various diseases, including cancer, neurodegenerative disorders, and metabolic diseases.'
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Proteins (1)

Compounds (6)