MOZ/MORF histone acetyltransferase complex

Definition

Target type: cellularcomponent

A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. [PMID:18794358]

The MOZ/MORF histone acetyltransferase (HAT) complex is a multi-protein complex involved in chromatin remodeling and transcriptional regulation. It is composed of several subunits, each contributing to its overall function. The core components of the complex include:

**1. MOZ (Monocytic Leukemia Zinc Finger Protein) or MORF (Myeloid Orphan Receptor F):** This is the catalytic subunit responsible for histone acetylation. It contains a bromodomain that recognizes acetylated lysines on histones and a histone acetyltransferase (HAT) domain that catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to lysine residues on histone tails.

**2. TIF1α (Transcriptional Intermediary Factor 1α):** This subunit acts as a scaffold protein that brings together the other components of the complex and facilitates its interaction with specific DNA sequences. It contains a PHD finger that interacts with methylated histone tails, a chromodomain that binds to specific DNA sequences, and a SANT domain that binds to histone acetyltransferases.

**3. ING (Inhibitor of Growth) Proteins:** These proteins can either enhance or inhibit the activity of the MOZ/MORF complex, depending on the specific ING isoform involved. Some ING isoforms contain a PHD finger that recognizes methylated histone tails, while others have a nucleosome binding domain that can bind directly to nucleosomes.

**4. Other Associated Proteins:** The MOZ/MORF complex can also interact with other proteins, such as the transcription factor E2F1, the histone demethylase LSD1, and the ubiquitin ligase MDM2. These interactions further regulate the activity of the complex.

**Cellular Component:**

The MOZ/MORF complex is primarily localized in the nucleus, where it associates with chromatin. It interacts with specific DNA sequences and modifies histone proteins, ultimately influencing the accessibility of DNA to transcription factors.

**Summary:**

The MOZ/MORF complex is a dynamic multi-protein complex that plays a critical role in chromatin remodeling and transcriptional regulation. Its specific composition and interactions with other proteins contribute to its diverse functions in cellular processes like development, differentiation, and tumorigenesis.'
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Proteins (3)

Compounds (7)